Basophils Orchestrating Eosinophils’ Chemotaxis and Function in Allergic Inflammation

Autor: Joseena Iype, Michaela Fux

Publikováno v: Cells, Vol 10, Iss 4, p 895 (2021)

Eosinophils are well known to contribute significantly to Th2 immunity, such as allergic inflammations. Although basophils have often not been considered in the pathogenicity of allergic dermatitis and asthma, their role in Th2 immunity has become ap

Externí odkaz: https://doaj.org/article/38b96716cc7a446381f6c1c6667ba927

IL‐1β promotes immunoregulatory responses in human blood basophils

Autor: Joseena Iype, Sofia Bachmann, Mazarine Coeudevez, Michaela Fux, Andrea Odermatt

Publikováno v: Allergy. 76:2017-2029

Human basophils are essential effector cells of chronic allergic inflammation. IL-1 family cytokines such as interleukin (IL)-33 and IL-1β are elevated in serum and bronchoalveolar lavage fluid of allergic asthmatics. IL-33 is known to be a critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad01f84033b7212eb01c94892461ca7
https://doi.org/10.1111/all.14760

Humoral and cellular responses to mRNA vaccines against SARS-CoV-2 in patients with a history of CD20 B-cell-depleting therapy (RituxiVac): an investigator-initiated, single-centre, open-label study

Autor: Cédric Hirzel, Linet M. Njue, Susanne Radonjic-Hoesli, Luca Borradori, Daniel Sidler, Daniel Aeberli, Joseena Iype, Michael P. Horn, Anne Angelillo-Scherrer, Burkhard Möller, Franziska Suter-Riniker, Matthias B. Moor, Britta Maurer, Robert Hoepner, S. Morteza Seyed Jafari, Laila-Yasmin Mani, Jennifer Amsler, Cesare Medri, Vera Ulrike Bacher, Andrew T. Chan

Publikováno v: The Lancet. Rheumatology

Background B-cell-depleting therapies increase the risk of morbidity and mortality due to COVID-19. Evidence-based SARS-CoV-2 vaccination strategies for patients on B-cell-depleting therapies are scarce. We aimed to investigate humoral and cell-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c2f75d7c1dae394c5bf2e10e489c1c
http://europepmc.org/articles/PMC8423431

Impact of BH3-mimetics on Human and Mouse Blood Leukocytes: A Comparative Study

Autor: Ramona Reinhart, Sofia Bachmann, Lionel Rohner, Joseena Iype, Thomas Kaufmann, Michaela Fux

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Rohner, Lionel; Reinhart, Ramona; Iype, Joseena; Bachmann, Sofia; Kaufmann, Thomas; Fux, Michaela (2020). Impact of BH3-mimetics on Human and Mouse Blood Leukocytes: A Comparative Study. Scientific reports, 10(1), p. 222. Springer Nature 10.1038/s41598-019-57000-x

BH3-mimetics are small molecule inhibitors that neutralize the function of anti-apoptotic BCL-2 family members. BH3-mimetics have recently gained a lot of popularity in oncology because of their success in cancer treatment. However, BH3-mimetics migh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d8c8560c509bdc20b92b424708bec
https://doi.org/10.1038/s41598-019-57000-x

MiR-155 Regulates Acute GvHD By Reducing NLRP3 Inflammasome Activity Via Targeting SOCS1 In Antigen-Presenting Cells

Autor: Sophia Chen, Joseena Iype, Sebastian Grundmann, Marco Idzko, Annette Schmitt-Gräff, Heide Dierbach, Yvonne Beck, Jürgen Finke, Justus Duyster, Robert Zeiser

Publikováno v: Blood. 122:3247-3247

Allogeneic hematopoietic cell transplantation (alloHCT) is limited by acute graft-versus-host disease (GvHD) which occurs in 30-40 % of patients. Despite numerous clinical studies, the standard immunosuppressive regimens for prevention of acute GvHD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22e8be7eaeee1a2bf94c7dc04c283a42
https://doi.org/10.1182/blood.v122.21.3247.3247