Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Joseck M. Muhuhi"'
1
Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 2. Fit-for-Purpose Optimization of the Route to Tyclopyrazoflor Featuring [3 + 2] Cyclization of 3-Hydrazinopyridine·2HCl and Methyl Acrylate
Autor: Beth A. Lorsbach, Joseck M. Muhuhi, Kaitlyn Gray, Podhorez David E, Xiaoyong Li, Qiang Yang, Gary Roth
Publikováno v: Organic Process Research & Development. 23:2133-2141
Optimization of the route to the sap-feeding insecticidal candidate tyclopyrazoflor featuring [3 + 2] cyclization of 3-hydrazinopyridine·2HCl and methyl acrylate is described. The key impurities in...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61de7a83dbf3c739880562d2afb382ce
https://doi.org/10.1021/acs.oprd.9b00128
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2
Developing Efficient Nucleophilic Fluorination Methods and Application to Substituted Picolinate Esters
Autor: Shin Hee Lee, Patrick S. Hanley, Yang Cheng, Gary Roth, Douglas C. Bland, Joseck M. Muhuhi, Bruce M. Bell, Melanie S. Sanford, John E. Anderson, Stacey L. Powers, Elisabeth J Kane, Laura J. Allen
Publikováno v: Organic Process Research & Development. 18:1045-1054
This report describes nucleophilic fluorination of 3 and 5-substituted picolinate ester substrates using potassium fluoride in combination with additive promoters. Agents such as tributylmethylammonium or tetraphenylphosphonium chloride were among th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::349d6db7a8a37e9f4be5a5802e148358
https://doi.org/10.1021/op5001258
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3
Mild Fluorination of Chloropyridines with in Situ Generated Anhydrous Tetrabutylammonium Fluoride
Autor: Melanie S. Sanford, Douglas C. Bland, Joseck M. Muhuhi, Laura J. Allen, Rachel L. Merzel
Publikováno v: The Journal of Organic Chemistry. 79:5827-5833
This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu4F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c313092f8e5a9e6ca88e6af2eae573d
https://doi.org/10.1021/jo5003054
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5
Development of a General, Sequential, Ring-Closing Metathesis/Intramolecular Cross-Coupling Reaction for the Synthesis of Polyunsaturated Macrolactones
Autor: Joseck M. Muhuhi, Scott E. Denmark
Publikováno v: Journal of the American Chemical Society. 132:11768-11778
A general strategy for the construction of macrocyclic lactones containing conjugated Z,Z-1,3-diene subunits has been is described. The centerpiece of the strategy is a sequential ring-closing metathesis that forms an unsaturated siloxane ring follow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4071e1061519ed52e82b11d2e7578a1
https://doi.org/10.1021/ja1047363
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6
ChemInform Abstract: Mild Fluorination of Chloropyridines with in situ Generated Anhydrous Tetrabutylammonium Fluoride
Autor: Rachel L. Merzel, Douglas C. Bland, Melanie S. Sanford, Laura J. Allen, Joseck M. Muhuhi
Publikováno v: ChemInform. 45
This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu4F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::702b6cdda934804f99116fea07d9578e
https://doi.org/10.1002/chin.201451039
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7
Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease
Autor: Kyriacos M. Koupparis, Iulia A. Kovari, Mark R. Spaller, Joseck M. Muhuhi, Krisztina Z. Bencze, Zhigang Liu, Ladislau C. Kovari, Ravikiran S. Yedidi, Carrie O'Connor
Publikováno v: Biochemical and biophysical research communications. 438(4)
Multidrug-resistant (MDR) clinical isolate-769, human immunodeficiency virus type-1 (HIV-1) protease (PDB ID: 1TW7), was shown to exhibit wide-open flaps and an expanded active site cavity, causing loss of contacts with protease inhibitors. In the cu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e1471d1403d0ec0fb3c9028a6ecda
https://pubmed.ncbi.nlm.nih.gov/23921229
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8
Stereocontrolled total syntheses of isodomoic acids G and H via a unified strategy
Autor: Joseck M. Muhuhi, Jack Hung Chang Liu, Scott E. Denmark
Publikováno v: The Journal of organic chemistry. 76(1)
Marine neuroexcitatory compounds isodomoic acids G and H were efficiently synthesized from a common intermediate using a silicon-based cross-coupling reaction. Dividing each target compound into the core fragment and the side-chain fragment enabled t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee60643e389da60af1b11aeadae826f
https://pubmed.ncbi.nlm.nih.gov/21121685
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10
Total syntheses of isodomoic acids G and H
Autor: Jack Hung Chang Liu, Scott E. Denmark, Joseck M. Muhuhi
Publikováno v: Journal of the American Chemical Society. 131(40)
The total syntheses of marine natural products belonging to the kainoid family, isodomoic acids G and H, are described. The strategic connection involves a sequential silylcarbocyclization/silicon-based cross-coupling process. These total syntheses w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd1e2544cf3c939f76c9bb09a1968a6
https://pubmed.ncbi.nlm.nih.gov/19807173
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