Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jose-Andres C Portillo"'
Autor:
Jose-Andres C Portillo, Luis Muniz-Feliciano, Yalitza Lopez Corcino, So Jung Lee, Jennifer Van Grol, Sarah J Parsons, William P Schiemman, Carlos S Subauste
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006671 (2017)
Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells kill the protozoan. Thus, the parasite must avoid autophagic targeting to survive. Here we show that the mammalian cytoplasmic molecule Focal Adhesion Kinase (F
Externí odkaz:
https://doaj.org/article/3d755043b8a842b89b6345efba3d9754
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144133 (2015)
CD40, CX3CL1 and TNF-α promote atheroma and neointima formation. CD40 and TNF-α are also central to the development of diabetic retinopathy while CX3CL1 may play a role in the pathogenesis of this retinopathy. The purpose of this study was to exami
Externí odkaz:
https://doaj.org/article/d31b6c7ac26a4627a020e6410e0f8c80
Autor:
Pauline Sebby Ogolla, Jose-Andres C Portillo, Christine L White, Krupen Patel, Bruce Lamb, Ganes C Sen, Carlos S Subauste
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003557 (2013)
PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(-/-) mice infected with T. gondii exhibited higher parasite load and wors
Externí odkaz:
https://doaj.org/article/f16ca556eb244d0d8736baae47a32097
Autor:
Luis Muniz-Feliciano, Jennifer Van Grol, Jose-Andres C Portillo, Lloyd Liew, Bing Liu, Cathleen R Carlin, Vern B Carruthers, Stephen Matthews, Carlos S Subauste
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003809 (2013)
Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome recruitment. Thus, the parasite survives by avoiding lysosomal degradation. However, autophagy ca
Externí odkaz:
https://doaj.org/article/a7e60ba2904940118547708938ad7a9e
Autor:
Jose-Andres C Portillo, Genevieve Okenka, Erin Reed, Angela Subauste, Jennifer Van Grol, Katrin Gentil, Masaaki Komatsu, Keiji Tanaka, Gary Landreth, Beth Levine, Carlos S Subauste
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14472 (2010)
Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-γ-dependent host protection in vivo. However, these protective effects occur independently of autophagosome formation. Thus, the in vivo role of
Externí odkaz:
https://doaj.org/article/5d9c72c332274918bbbaaf76d7bde724
Autor:
Jose-Andres C. Portillo, Amelia Pfaff, Sarah Vos, Matthew Weng, Ram H. Nagaraj, Carlos S. Subauste
Publikováno v:
Cells, Vol 13, Iss 5, p 429 (2024)
CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40 upregulation is a central feature of CD40-driven i
Externí odkaz:
https://doaj.org/article/497d28e347cd4e8c943649e98d19e1ba
Autor:
Jose-Andres C, Portillo, Jin-Sang, Yu, Sarah, Vos, Reena, Bapputty, Yalitza, Lopez Corcino, Alyssa, Hubal, Jad, Daw, Sahil, Arora, Wenyu, Sun, Zheng-Rong, Lu, Carlos S, Subauste
Publikováno v:
Diabetologia. 65:2157-2171
Aims/hypothesisCD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in Müller cells followed by purinergic receptor (P2X7)-dependent production of proinflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9fb525b518fa6d2183c346914fe7b
https://doi.org/10.1007/s00125-022-05775-6
https://doi.org/10.1007/s00125-022-05775-6
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose CD40 is an upstream inducer of inflammation in the diabetic retina. CD40 is upregulated in retinal endothelial cells in diabetes. The purpose of this study was to determine whether expression of CD40 in endothelial cells is sufficient to prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94fe7747fa2a223dadb753c89731487
https://pubmed.ncbi.nlm.nih.gov/34546322
https://pubmed.ncbi.nlm.nih.gov/34546322
Autor:
Jose-Andres C. Portillo, Jin‐Sang Yu, Carlos S. Subauste, Samuel Hansen, M. Cecilia Subauste, Timothy S. Kern
Publikováno v:
The FASEB Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 35, iss 3
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 35, iss 3
While the administration of anti‐CD154 mAbs in mice validated the CD40‐CD154 pathway as a target against inflammatory disorders, this approach caused thromboembolism in humans (unrelated to CD40 inhibition) and is expected to predispose to opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1699534f450cacb7dd26b452eb2352
http://europepmc.org/articles/PMC8101361
http://europepmc.org/articles/PMC8101361
Autor:
Nicole L. Ward, Saad Saffo, George R. Dubyak, Myriam E. Rodriguez, Yalitza Lopez Corcino, Roxana E. Rojas, Barbara A. Fox, Zahra Toosi, Jose-Andres C. Portillo, Carlos S. Subauste, Jennifer Van Grol, David J. Bzik
Publikováno v:
Infection and Immunity. 87
Little is known about whether pathogen invasion of neural tissue is affected by immune-based mechanisms in endothelial cells. We examined the effects of endothelial cell CD40 on Toxoplasma gondii invasion of the retina and brain, organs seeded hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b5bc490be295bb31b3fae6f2270e67
https://doi.org/10.1128/iai.00868-18
https://doi.org/10.1128/iai.00868-18