Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jose Verdezoto Mosquera"'
Autor:
Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100465- (2024)
Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci du
Externí odkaz:
https://doaj.org/article/edb54c8409764f119fe134388ec9ee15
Autor:
Mengxue Zhang, Jing Li, Qingwei Wang, Go Urabe, Runze Tang, Yitao Huang, Jose Verdezoto Mosquera, K. Craig Kent, Bowen Wang, Clint L. Miller, Lian-Wang Guo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 717-729 (2023)
Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and activation
Externí odkaz:
https://doaj.org/article/9b065267a6a6463fa7b9506f5322e25e
Autor:
Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. Sheffield, Clint L. Miller
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113380- (2023)
Summary: Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (sc
Externí odkaz:
https://doaj.org/article/f36322cc9dc74a4986bc713522f0f6e4
Autor:
Atsushi Sakamoto, Rika Kawakami, Masayuki Mori, Liang Guo, Ka Hyun Paek, Jose Verdezoto Mosquera, Anne Cornelissen, Saikat Kumar B. Ghosh, Kenji Kawai, Takao Konishi, Raquel Fernandez, Daniela T. Fuller, Weili Xu, Aimee E. Vozenilek, Yu Sato, Hiroyuki Jinnouchi, Sho Torii, Adam W. Turner, Hirokuni Akahori, Salome Kuntz, Craig C. Weinkauf, Parker J. Lee, Robert Kutys, Kathryn Harris, Alfred Lawrence Killey, Christina M. Mayhew, Matthew Ellis, Leah M. Weinstein, Neel V. Gadhoke, Roma Dhingra, Jeremy Ullman, Armella Dikongue, Maria E. Romero, Frank D. Kolodgie, Clint L. Miller, Renu Virmani, Aloke V. Finn
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why rupture-prone high-risk plaques do not typically show extensive calcification. Intraplaque hemorrhage (IPH) deposits erythrocyte-derived cholesterol, enlarg
Externí odkaz:
https://doaj.org/article/8740bbd2d80a403998184d09c002a1e7
Autor:
Kristyna Kupkova, Jose Verdezoto Mosquera, Jason P. Smith, Michał Stolarczyk, Tessa L. Danehy, John T. Lawson, Bingjie Xue, John T. Stubbs, Nathan LeRoy, Nathan C. Sheffield
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-6 (2022)
Abstract Background Epigenome analysis relies on defined sets of genomic regions output by widely used assays such as ChIP-seq and ATAC-seq. Statistical analysis and visualization of genomic region sets is essential to answer biological questions in
Externí odkaz:
https://doaj.org/article/950b81e1220f40159c7dd5c9d6968d0e
Autor:
Wei Feng Ma, Adam W. Turner, Christina Gancayco, Doris Wong, Yipei Song, Jose Verdezoto Mosquera, Gaëlle Auguste, Chani J. Hodonsky, Ajay Prabhakar, H. Atakan Ekiz, Sander W. van der Laan, Clint L. Miller
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools have grown exponentially, th
Externí odkaz:
https://doaj.org/article/89d0a6900b2d4ccca5ec751d0190c2cc
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009602 (2021)
Fat stored in the form of lipid droplets has long been considered a defining characteristic of cytoplasm. However, recent studies have shown that nuclear lipid droplets occur in multiple cells and tissues, including in human patients with fatty liver
Externí odkaz:
https://doaj.org/article/95ab9d1fd0ab4f7a9acb8a62bb06da8b
Autor:
Doris Wong, Gaëlle Auguste, Christian L. Lino Cardenas, Adam W. Turner, Yixuan Chen, Yipei Song, Lijiang Ma, R. Noah Perry, Redouane Aherrahrou, Maniselvan Kuppusamy, Chaojie Yang, Jose Verdezoto Mosquera, Collin J. Dube, Mohammad Daud Khan, Meredith Palmore, Jaspreet Kalra, Maryam Kavousi, Patricia A. Peyser, Ljubica Matic, Ulf Hedin, Ani Manichaikul, Swapnil K. Sonkusare, Mete Civelek, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, Clint L. Miller
Publikováno v:
Circulation Research, 132(9), 1144-1161. Lippincott Williams & Wilkins
Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe5ac5ce89e69f5b733b655149c1b64
https://doi.org/10.1161/CIRCRESAHA.122.321692
https://doi.org/10.1161/CIRCRESAHA.122.321692
Autor:
Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publikováno v:
medRxiv
Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d152fbce7e888b92e0db700db7e04a
https://doi.org/10.1101/2023.02.09.23285622
https://doi.org/10.1101/2023.02.09.23285622
Autor:
Chani J. Hodonsky, Alexandra V. Ligay, Gary K. Owens, Michal Mokry, Bohdan B. Khomtchouk, Huize Pan, Katherine Owsiany, Clint L. Miller, Adam W. Turner, Nelson B. Barrientos, David Mai, Lotte Slenders, Wei Feng Ma, Gabriel F. Alencar, Yipei Song, Mingyao Li, Muredach P. Reilly, Doris Wong, Gerard Pasterkamp, Sander W. van der Laan, Christina A. Gancayco, Jose Verdezoto Mosquera
Publikováno v:
Atherosclerosis
Background and aims The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate plaque stability are not yet available. We sought to develop a scRNA-seq analysis workflow to investigate this environment and uncov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e020cb2e04a1bd1f3d1332eb6f76e77
https://europepmc.org/articles/PMC8919504/
https://europepmc.org/articles/PMC8919504/