Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jose Van der Heyden"'
Autor:
Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, Jose Van der Heyden, Tom Taghon, Georges Leclercq, Tessa Kerre, Jan Tavernier, Bart Vandekerckhove
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 883 (2020)
Recent approval of chimeric antigen receptor (CAR) T cell therapy by the European Medicines Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR T clinical trials illustrate the curative potential of this therapy. Whil
Externí odkaz:
https://doaj.org/article/83a54f189b9d4f34951f075863969ccb
Autor:
Jose Van der Heyden, Martynas Gavutis, Jacob Piehler, Diego Jaitin, Gilles Uzé, Laila C. Roisman, Gideon Schreiber, Eva Jaks
Alpha and beta interferons (IFN-alpha and IFN-beta) are multifunctional cytokines that exhibit differential activities through a common receptor composed of the subunits IFNAR1 and IFNAR2. Here we combined biophysical and functional studies to explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a82b38d3118e8fa26d782a5b72cbf6
https://europepmc.org/articles/PMC1430259/
https://europepmc.org/articles/PMC1430259/
Publikováno v:
Journal of molecular biology. 350(3)
Ligand-induced cross-linking of the type I interferon (IFN) receptor subunits ifnar1 and ifnar2 induces a pleiotrophic cellular response. Several studies have suggested differential signal activation by flexible recruitment of the accessory receptor
Autor:
Anje Cauwels, Sandra Van Lint, Geneviève Garcin, Jennyfer Bultinck, Franciane Paul, Sarah Gerlo, José Van der Heyden, Yann Bordat, Dominiek Catteeuw, Lode De Cauwer, Elke Rogge, Annick Verhee, Gilles Uzé, Jan Tavernier
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized immunocytokines that,
Externí odkaz:
https://doaj.org/article/fe18f4ea4f164935b446279ebe4c2ff6
Publikováno v:
Nature. 301(5901)
Human fibroblast cells produce beta-type interferon only in response to viral infection or treatment with an inducer such as poly(rI) X poly(rC); this event is most probably controlled at the transcriptional level (for review see ref. 1). To study th