Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jose Rueff"'
Publikováno v:
Journal of Xenobiotics, Vol 14, Iss 2, Pp 575-603 (2024)
Progesterone receptor membrane component 1 (PGRMC1) is one of few proteins that have been recently described as direct modulators of the activity of human cytochrome P450 enzymes (CYP)s. These enzymes form a superfamily of membrane-bound hemoproteins
Externí odkaz:
https://doaj.org/article/c881402b56ee4ab29ec0f1303888a296
Publikováno v:
Research in Statistics, Vol 2, Iss 1 (2024)
AbstractChromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. I
Externí odkaz:
https://doaj.org/article/2fc6c9184e1b48a5843ebac669ebb961
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Genetic compositions of distinct human populations are different. How genomic variants influence many common and rare genetic diseases is always of great medical and anthropological interest, and understanding of genetic architectures of pop
Externí odkaz:
https://doaj.org/article/831c3538554b467dbb6e482375cbbf8b
Autor:
Ana Fernandes, Maria Fátima Cabral, Nuno Oliveira, Madalena Cipriano, Jose Rueff, Judite Costa, Jorge Gaspar, Matilde Castro
Publikováno v:
Free Radical Research. 46:1157-1166
The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24715a15c16a23cb9d862ebfcc5b288
https://doi.org/10.3109/10715762.2012.695869
https://doi.org/10.3109/10715762.2012.695869
Autor:
Fernanda Marques, António Paulo, Isabel Santos, Antonio Sebastião Rodrigues, Paula Raposinho, Luis Costa, Rute Maria Filipe Vitor, Jose Rueff, Teresa Esteves, Sandra Casimiro
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 24:551-563
Different pyrazolyl-diamine ligands bearing anthracenyl or anthrapyrazole functionalities as DNA-binding groups, at different positions of the chelator framework, were labeled with the fac-[(99m)Tc(CO)(3)](+) core. The resulting complexes, 1-4, are h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d4d3811262a2aba8a04721af23e7ee
https://doi.org/10.1089/cbr.2009.0647
https://doi.org/10.1089/cbr.2009.0647
Autor:
Ana Fernandes, Maria Fátima Cabral, Nuno Oliveira, Jose Rueff, Judite Costa, Jorge Gaspar, Matilde Castro, Cátia Caneiras, Rita Guedes
Publikováno v:
Journal of Inorganic Biochemistry. 101:849-858
Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2c415f6c68511f2a950a150ebae141
https://doi.org/10.1016/j.jinorgbio.2007.01.013
https://doi.org/10.1016/j.jinorgbio.2007.01.013
Publikováno v:
Current Pharmacogenomics. 5:39-47
Advances in nanoscience are having a significant impact on many scientific fields, boosting the development of a variety of important technologies. The impact of these new technologies is particularly large in biodiagnostics, where a number of nanopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f915d8b3f198e106c809f8ea5fb10a12
https://doi.org/10.2174/157016007780077185
https://doi.org/10.2174/157016007780077185
Publikováno v:
AIP Conference Proceedings.
This work was partially supported by CIGMH (FCM/UNL), PEST-OE/SAU/UI0009/2011 and CMA/FCT/UNL, under the project PEst-OE/MAT/UI0297/2011. Integration of the human immunodeficiency virus (HIV) DNA into human genome is essential for HIV-induced disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b5b9db4812f97aeddd35ef33d371c0
https://doi.org/10.1063/1.4825619
https://doi.org/10.1063/1.4825619
Autor:
Francisco Esteves, Cristina M. M. Almeida, Sofia Silva, Inês Saldanha, Philippe Urban, José Rueff, Denis Pompon, Gilles Truan, Michel Kranendonk
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1083 (2023)
A unique cytochrome P450 (CYP) oxidoreductase (CPR) sustains activities of human microsomal CYPs. Its function requires toggling between a closed conformation enabling electron transfers from NADPH to FAD and then FMN cofactors and open conformations
Externí odkaz:
https://doaj.org/article/f62d15d3be7b4883af44a3ed7f77817f
Publikováno v:
Journal of Xenobiotics, Vol 11, Iss 3, Pp 94-114 (2021)
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound hemoproteins that are responsible for the metabolism of a wide variety of clinically, physiologically, and toxicologically important compounds. These heme-thiolate monooxy
Externí odkaz:
https://doaj.org/article/f62a7b0591ab4024b2099490050f7ec1