Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jose R. Regueiro"'
Autor:
Beatriz Garcillán, Rebeca F. Megino, Marta Herrero-Alonso, Alberto C. Guardo, Veronica Perez-Flores, Claudia Juraske, Vincent Idstein, Jose M. Martin-Fernandez, Carsten Geisler, Wolfgang W. A. Schamel, Ana V. Marin, Jose R. Regueiro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ—) show reduced surface TCR expression levels and abolished phorbol ester (PMA)-induced TCR down-regu
Externí odkaz:
https://doaj.org/article/ee3075c5866d4f45b4af9db868d1fc27
Autor:
Elaine P. Dopfer, Frederike A. Hartl, Hans-Heinrich Oberg, Gabrielle M. Siegers, O. Sascha Yousefi, Sylvia Kock, Gina J. Fiala, Beatriz Garcillán, Andrew Sandstrom, Balbino Alarcón, Jose R. Regueiro, Dieter Kabelitz, Erin J. Adams, Susana Minguet, Daniela Wesch, Paul Fisch, Wolfgang W.A. Schamel
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1704-1715 (2014)
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for αβTCR activation. Here, we demonstrate tha
Externí odkaz:
https://doaj.org/article/d96a71cd8e9c4d03be71b8194bfc3b6e
Autor:
Javier León, Ester Molina, Lucia Garcia-Gutierrez, Vanessa Junco, Mercedes Perez-Olivares, Virginia G. de Yebenes, Rosa Blanco, Laura Quevedo, Juan C. Acosta, Ana V. Marin, Daniela Ulgiati, Ramon Merino, Ignacio Varela, Jose R. Regueiro, Ignacio Morenos de Alboran, Almudena R. Ramiro
MYC is an oncogenic transcription factor dysregulated in about half of total human tumors. Transcriptomic studies reveal more than 1000 genes regulated by MYC but a much smaller fraction of genes is directly transactivated by MYC. Virtually all Burki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db351e011b7844f167b1191c3dd3bcd8
https://doi.org/10.21203/rs.3.rs-2538215/v1
https://doi.org/10.21203/rs.3.rs-2538215/v1
Autor:
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José R. Regueiro, Eduardo Martínez-Naves, Mohamed Ramadan Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andreea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, María Dolores Frutos, Bruno Ramos Molina, José María Herranz, Matías A. Ávila, Yulia A. Nevzorova, Edgar Fernández-Malavé, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-bin
Externí odkaz:
https://doaj.org/article/01a591f664c741c59cc9c983321052fd
Autor:
Ana V. Marin, Rebeca F. Megino, Marcos Viñuela, Olga Popova, Irene Real-Arevalo, Jose L. Sanchez-Majano, Pablo L. Ortiz-Romero, Maria J. Castro-Panete, Esther Mancebo, Paloma Talayero, Estela Paz-Artal, Maria L. Paciello, Joaquin Martinez-Lopez, Jose L. Subiza, Pedro A. Reche, Nuria Lopez-Bigas, Miguel Marcilla, Alberto Paradela, Manuel Gomez del Moral, Eduardo Martinez-Naves, Alvaro Serrano, Ester Marina-Zarate, Almudena R. Ramiro, Pablo Engel, Mercedes Dominguez, Inmaculada Moreno, Isabel Cortegano, Belen de Andres, Maria L. Gaspar, Marina Garcia-Peydro, Antonio Balas, Miguel A. Moreno, Raquel Alenda, Jose L. Vicario, Immanuel F. Luescher, Maria L. Toribio, Balbino Alarcon, Jose R. Regueiro
Publikováno v:
The Journal of Immunology. 206:67.20-67.20
Sézary syndrome (SS) is a leukemic form of cutaneous mature T-cell lymphoma characterized by circulating malignant CD4 T lymphocytes (Sezary cells). Patients with SS have a poor prognosis and current treatment options show high rates of relapse, mor
Autor:
Jared H, Rowe, Ottavia M, Delmonte, Sevgi, Keles, Brian D, Stadinski, Adam K, Dobbs, Lauren A, Henderson, Yasuhiro, Yamazaki, Luis M, Allende, Francisco A, Bonilla, Luis I, Gonzalez-Granado, Seyma, Celikbilek Celik, Sukru N, Guner, Hasan, Kapakli, Christina, Yee, Sung-Yun, Pai, Eric S, Huseby, Ismail, Reisli, Jose R, Regueiro, Luigi D, Notarangelo
Publikováno v:
Blood. 131(21)
CD3γ-deficient patients manifest T-cell phenotypic and functional defects that are especially prominent in Treg cells.The peripheral T-cell repertoire of CD3γ-deficient patients is restricted, with molecular signatures of self-reactivity.
Autor:
Ana V. Marin, Anaïs Jiménez-Reinoso, Marina S. Mazariegos, Elena Román-Ortiz, José R. Regueiro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Schimke immuno-osseous dysplasia (SIOD) caused by mutations in SMARCAL1 is an ultra-rare disease characterized by specific facial features, skeletal dysplasia, and steroid-resistant nephrotic syndrome, which often leads to kidney failure and requires
Externí odkaz:
https://doaj.org/article/a9a45358424c4b68b5ed2dc6fc826c39
Autor:
Gabrielle M, Siegers, Mahima, Swamy, Edgar, Fernández-Malavé, Susana, Minguet, Sylvia, Rathmann, Alberto C, Guardo, Verónica, Pérez-Flores, Jose R, Regueiro, Balbino, Alarcón, Paul, Fisch, Wolfgang W A, Schamel
Publikováno v:
The Journal of Experimental Medicine
The gammadelta T cell receptor for antigen (TCR) comprises the clonotypic TCRgammadelta, the CD3 (CD3gammaepsilon and/or CD3deltaepsilon), and the zetazeta dimers. gammadelta T cells do not develop in CD3gamma-deficient mice, whereas human patients l
Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome
Autor:
Mohammad A, Karim, Koji, Suzuki, Kazuyoshi, Fukai, Jangsuk, Oh, Deborah L, Nagle, Karen J, Moore, Ernest, Barbosa, Tzipora, Falik-Borenstein, Alexandra, Filipovich, Yasushi, Ishida, Sirpa, Kivrikko, Christoph, Klein, Friedmar, Kreuz, Alex, Levin, Hiroaki, Miyajima, Jose R, Regueiro, Carolyn, Russo, Eiichiro, Uyama, Outi, Vierimaa, Richard A, Spritz
Publikováno v:
American journal of medical genetics. 108(1)
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized by severe immunologic defects, reduced pigmentation, bleeding tendency, and progressive neurological dysfunction. Most patients present in early childhood and die unl
Autor:
Beatriz Garcillán, Patricia Fuentes, Ana V. Marin, Rebeca F. Megino, Daniel Chacon-Arguedas, Marina S. Mazariegos, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Maria L. Toribio, José R. Regueiro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD2472). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is
Externí odkaz:
https://doaj.org/article/f22f1ad542f849088084b9af82e689f6