Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jose R. Hombrebueno"'
Autor:
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J. Lyons, Nicholas M. Barnes, Parth Narendran, Janet M. Lord, Saaeha Rauz, Ian G. Ganley, Tim M. Curtis, Graham R. Wallace, Jose R. Hombrebueno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and turno
Externí odkaz:
https://doaj.org/article/49bb462680fd472a9c0826d8dc86da53
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/5acaea5e4dbf4905b393e17a565273c5
Autor:
Linan Xu, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Ashling Holland, Kevin S. Edgar, Jose R. Hombrebueno, Donna Beer Stolz, Ewa Oleszycka, Aoife M. Rodgers, Nadezhda Glezeva, Kenneth McDonald, Chris J. Watson, Mark T. Ledwidge, Rebecca J. Ingram, David J. Grieve, Paul N. Moynagh
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://doaj.org/article/0345bb89fc434b80b4c4d1233fd83303
Autor:
Aoife M. Rodgers, Ewa Oleszycka, Kevin S Edgar, Kenneth McDonald, Chris Watson, Jose R. Hombrebueno, Linan Xu, Paul N. Moynagh, Ashling Holland, Mark Ledwidge, David J. Grieve, Rebecca J. Ingram, Nadezhda Glezeva, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Donna B. Stolz
Publikováno v:
Xu, L, Humphries, F, Delagic, N, Wang, B, Holland, A, Edgar, K S, Hombrebueno, J R, Stolz, D B, Oleszycka, E, Rodgers, A M, Glezeva, N, McDonald, K, Watson, C J, Ledwidge, M T, Ingram, R J, Grieve, D J & Moynagh, P N 2021, ' ECSIT is a critical limiting factor for cardiac function ', JCI insight, vol. 6, no. 12, e142801 . https://doi.org/10.1172/jci.insight.142801
JCI Insight
JCI Insight
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfeef42f1038b41ab2881b39ebdd595
https://pure.qub.ac.uk/en/publications/87c025e6-1960-482c-8e49-138c25174aa6
https://pure.qub.ac.uk/en/publications/87c025e6-1960-482c-8e49-138c25174aa6
Publikováno v:
Diabetes and Vascular Disease Research. 16:440-449
The purpose of this study was to understand the influence of sustained intravitreal vascular endothelial growth factor neutralisation on the retinal and choroidal vasculature in diabetic eyes. Ins2Akita diabetic mice received five intravitreal inject
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97970 (2014)
Retinal neurodegeneration is a key component of diabetic retinopathy (DR), although the detailed neuronal damage remains ill-defined. Recent evidence suggests that in addition to amacrine and ganglion cell, diabetes may also impact on other retinal n
Externí odkaz:
https://doaj.org/article/bc19491a92a34cba9630ae762061d5c6
Autor:
Denise Hoch, Guillermo Lopez Campos, Tatjana Simic, Ross McNally, Naomi Todd, Louise C. Kenny, Abdelrahim Alqudah, Ian S. Young, David J. Grieve, Gernot Desoye, Chris J Watson, Anna Krasnodembskaya, David R. McCance, Tracy Robson, Lana McClements, Jose R. Hombrebueno, Djurdja Jerotic, Miroslava Gojnic-Dugalic, Alyson Hunter, Kelly-Ann Eastwood, Sonja Suvakov, Valerie Holmes, Vesna D. Garovic, Danilo Obradovic
Publikováno v:
Todd, N, McNally, R, Alqudah, A, Jerotic, D, Suvakov, S, Obradovic, D, Hoch, D, Hombrebueno, J R, Campos, G L, Watson, C J, Gojnic-Dugalic, M, Simic, T P, Krasnodembskaya, A, Desoye, G, Eastwood, K-A, Hunter, A J, Holmes, V A, McCance, D R, Young, I S, Grieve, D J, Kenny, L C, Garovic, V D, Robson, T & McClements, L 2021, ' Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment ', The Journal of Clinical Endocrinology & Metabolism, vol. 106, no. 1, pp. 26-41 . https://doi.org/10.1210/clinem/dgaa403
The Journal of Clinical Endocrinology and Metabolism
The Journal of Clinical Endocrinology and Metabolism
Context Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies. Objective To investigate the diagnostic and therapeutic target potential of the angiogenesis proteins, FK506-binding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddec4b6c2acf3d89a7d0beff3d7d0490
https://hdl.handle.net/10453/145812
https://hdl.handle.net/10453/145812
Autor:
Jose R. Hombrebueno, Aisling Lynch, Eimear M. Byrne, Gideon Obasanmi, Heping Xu, Adrien Kissenpfennig, Mei Chen
Publikováno v:
Hombrebueno, J R, Lynch, A, Byrne, E M, Obasanmi, G, Kissenpfennig, A, Chen, M & Xu, H 2020, ' Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 12, pp. e367-e379 . https://doi.org/10.1161/ATVBAHA.120.314567
Objective: Myeloid cells are critically involved in inflammation-induced angiogenesis, although their pathogenic role in the ischemic retina remains controversial. We hypothesize that myeloid cells contribute to pathogenic neovascularization in retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8208cb882a1a467d689d10174a041cd9
https://pure.qub.ac.uk/en/publications/hyaloid-vasculature-as-a-major-source-of-stat3-signal-transducer-and-activator-of-transcription-3-myeloid-cells-for-pathogenic-retinal-neovascularization-in-oxygeninduced-retinopathy(aea85dcf-766f-412d-a46d-4bc425ea0ca0).html
https://pure.qub.ac.uk/en/publications/hyaloid-vasculature-as-a-major-source-of-stat3-signal-transducer-and-activator-of-transcription-3-myeloid-cells-for-pathogenic-retinal-neovascularization-in-oxygeninduced-retinopathy(aea85dcf-766f-412d-a46d-4bc425ea0ca0).html
Autor:
Mei Chen, Jose R Hombrebueno, Chang Luo, Rosana Penalva, Jiawu Zhao, Liza Colhoun, Sudha Pirya Soundara Pandi, John V Forrester, Heping Xu
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61381 (2013)
Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration. In this study, we generated CCL2(-/-)CX3CR1(GFP/GFP) mice on the C57BL/6J backgr
Externí odkaz:
https://doaj.org/article/4196744f55274fb18c65bf0d1e52bc03
Autor:
Jose R, Hombrebueno, Aisling, Lynch, Eimear M, Byrne, Gideon, Obasanmi, Adrien, Kissenpfennig, Mei, Chen, Heping, Xu
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 40(12)
Myeloid cells are critically involved in inflammation-induced angiogenesis, although their pathogenic role in the ischemic retina remains controversial. We hypothesize that myeloid cells contribute to pathogenic neovascularization in retinopathy of p