Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Jose R. Conejo-Garcia"'
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Sandhya Prabhakaran, Ottilie Swinyard, Robbert J. C. Slebos, Gunjan Mandal, Eoghan Mulholland, Noemi Andor, Andriy Marusyk, Simon Leedham, Jose R. Conejo-Garcia, Christine H. Chung, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and access to technology. An alternative approach is to register collections of whole
Externí odkaz:
https://doaj.org/article/27aa67cd79b24cdf8baff050f7387c85
Publikováno v:
Life, Vol 14, Iss 3, p 325 (2024)
Immuno-oncology has traditionally focused on conventional MHC-restricted αβ T cells. Yet, unconventional γδ T cells, which kill tumor cells in an MHC-unrestricted manner, display characteristics of effector activity and stemness without exhaustio
Externí odkaz:
https://doaj.org/article/b19307fe8929452299c70de55b93fa93
Autor:
Rachel C. Newsome, Raad Z. Gharaibeh, Christine M. Pierce, Wildson Vieira da Silva, Shirlene Paul, Stephanie R. Hogue, Qin Yu, Scott Antonia, Jose R. Conejo-Garcia, Lary A. Robinson, Christian Jobin
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Recent studies show that human gut microbial composition can determine whether a patient is a responder or non-responder to immunotherapy but have not identified a common microbial signal shared by responding patients. The functio
Externí odkaz:
https://doaj.org/article/91a0ce6cc50b4f098348471265ee7dcd
Autor:
Ahmad A. Tarhini, Wissam B. Hanayneh, John J. Powers, Carlos M. Moran Segura, Jose R. Conejo-Garcia, Cesar A. Lam, Ardeshir Hakam, Mitchel S. Hoffman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Optimal management of locally advanced vaginal mucosal melanoma is poorly understood because of its rarity and unique biology. Patients have a poor prognosis despite aggressive management approaches including pelvic exenteration and adjuvant radiatio
Externí odkaz:
https://doaj.org/article/476e987699474f28ab57ce3b5e9e6fd0
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101649- (2022)
Summary: Understanding the heterogenicity of tumor-infiltraing lymphocyte (TIL) populations and the immunobiology in human cancer is a key to establish efficient immunotherapies. Here, we have established a protocol for the characterization of CD8+ T
Externí odkaz:
https://doaj.org/article/3df006057ced4d7f9295ca33ee123e90
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
The distribution of Endometrial Cancer (EC)-related deaths is uneven among the morphologic subtypes of EC. Serous Cancer (SC) makes 10% of all EC and accounts for 40% of EC-related deaths. We investigated expression of selected genes involved in epig
Externí odkaz:
https://doaj.org/article/0299fe5546354d69ac7d3f46c4ae7cdf
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The rapid development of single-cell RNA sequencing (scRNA-seq) provides unprecedented opportunities to study the tumor ecosystem that involves a heterogeneous mixture of cell types. However, the majority of previous and current s
Externí odkaz:
https://doaj.org/article/aeb9ef1fd1eb4d15ad3409bf1f0b94e7
Autor:
Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting
Externí odkaz:
https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
Autor:
Takeshi Fukumoto, Pyoung Hwa Park, Shuai Wu, Nail Fatkhutdinov, Sergey Karakashev, Timothy Nacarelli, Andrew V. Kossenkov, David W. Speicher, Stephanie Jean, Lin Zhang, Tian-Li Wang, Ie-Ming Shih, Jose R. Conejo-Garcia, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3393-3400 (2018)
Summary: ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show tha
Externí odkaz:
https://doaj.org/article/c03c4b3064504442808ca962aa2f53e5
Autor:
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tum
Externí odkaz:
https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc