Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Jose R Perez-Polo"'
Publikováno v:
Journal of cardiovascular pharmacology. 75(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236a81bf57384f25952b62f4ce1ef44c
https://pubmed.ncbi.nlm.nih.gov/31274838
https://pubmed.ncbi.nlm.nih.gov/31274838
Autor:
Sven Nylander, Yochai Birnbaum, Gilad D. Birnbaum, Yumei Ye, Jose R. Perez-Polo, Manjyot K. Nanhwan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1805-1814
Objective— In addition to P2Y 12 receptor antagonism, ticagrelor inhibits adenosine cell uptake. Prior data show that 7-day pretreatment with ticagrelor limits infarct size. We explored the acute effects of ticagrelor and clopidogrel on infarct siz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d652c779b037eb92e1d5cafb28cf1f7
https://doi.org/10.1161/atvbaha.115.305655
https://doi.org/10.1161/atvbaha.115.305655
Autor:
Kathia M. Johnson, Claire E. Hulsebosch, Jose R. Perez-Polo, K. Werrbach-Perez, Donald S. Prough, Geda Unabia, Harriett C. Rea, Guo-Ying Xu, Margaret A. Parsley, Douglas S. DeWitt, A. A. Paulucci-Holthauzen
Publikováno v:
Journal of Neuroscience Research. 94:27-38
In rodent models of traumatic brain injury (TBI), both Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα) levels increase early after injury to return later to basal levels. We have developed and characterized a rat mild fluid percussion m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a26fc7527bb8149855ef9efe9691144d
https://doi.org/10.1002/jnr.23617
https://doi.org/10.1002/jnr.23617
Publikováno v:
Cardiovascular drugs and therapy. 31(2)
We assessed whether (1) dapagliflozin (Dapa, an SGLT2-inhibitor) attenuates the deterioration of heart function Nlrp3 and inflammasome activation in diabetic mice. (2) The effects can be augmented with saxagliptin (Saxa), a DDP4-inhibitor. (3) Dapa e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef739e56291313e4fccd06c1d0588b4
https://pubmed.ncbi.nlm.nih.gov/28447181
https://pubmed.ncbi.nlm.nih.gov/28447181
Autor:
Harriett C. Rea, Heidi Spratt, Donald S. Prough, Guo-Ying Xu, Claire E. Hulsebosch, Margaret A. Parsley, Geda Unabia, Jose R. Perez-Polo, Douglas S. DeWitt, Kathia M. Johnson
Publikováno v:
Journal of Neuroscience Research. 93:549-561
One of the criteria defining mild traumatic brain injury (mTBI) in humans is a loss of consciousness lasting for less than 30 min. mTBI can result in long-term impairment of cognition and behavior. In rats, the length of time it takes a rat to right
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73e013f3c44014580f5db173279d274b
https://doi.org/10.1002/jnr.23513
https://doi.org/10.1002/jnr.23513
Autor:
Alexander C. Castillo, Jinqiao Qian, Shukuan Ling, Hongmei Ye, Bo Long, Yumei Ye, Jose R. Perez-Polo, Yochai Birnbaum, Bejoy Thomas, Xiaoping Chen
Publikováno v:
Hypertension. 61:1008-1013
Nebivolol is a selective β1-blocker with nitric oxide–enhancing effects. MicroRNAs are small noncoding RNA molecules that downregulate gene expression. We compared the effects of nebivolol and atenolol, a first generation β1-selective blocker, on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78c9ab4818d9a5447f838c2ddb0c572
https://doi.org/10.1161/hypertensionaha.111.00892
https://doi.org/10.1161/hypertensionaha.111.00892
Publikováno v:
Physiological Genomics. 43:534-542
MicroRNAs (miRNAs) are small (∼22 nt) noncoding single-stranded RNA molecules that downregulate gene expression. Studies have shown that miRNAs control diverse aspects of heart disease, including hypertrophy, remodeling, heart failure, and arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48331b0103cb061bb2a81ca88e9f64c8
https://doi.org/10.1152/physiolgenomics.00130.2010
https://doi.org/10.1152/physiolgenomics.00130.2010
Publikováno v:
Basic Research in Cardiology. 106:431-446
Pioglitazone (PIO), a PPAR-γ agonist, limits myocardial infarct size by activating Akt and upregulating cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenase (COX)-2. However, PIO has several PPAR-γ-independent effects. We assessed whether PIO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d79c94d59862c48de0a397a6b52d33
https://doi.org/10.1007/s00395-011-0162-3
https://doi.org/10.1007/s00395-011-0162-3
Publikováno v:
Cardiovascular Drugs and Therapy
Purpose Statins protect against ischemia-reperfusion injury and limit myocardial infarct size (IS). This effect is dependent on increased generation of adenosine by ecto-5′ nucleotidase and downstream activation of cyclooxygenase-2 (COX2). Dipyrida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988f3073b3e7c57ef8b28937d3f808c
https://doi.org/10.1007/s10557-010-6252-x
https://doi.org/10.1007/s10557-010-6252-x
Publikováno v:
Annals of the New York Academy of Sciences. 1207:76-82
Statins and antiplatelet agents are currently used as therapeutic agents for patients with acute myocardial infarction. Statins limit myocardial infarct size by activating phosphatidylinositol-3-kinase (PI3K), ecto-5'-nucleotidase, Akt/endothelial ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56e4021d95a33ebb1c8d06e7f91118
https://doi.org/10.1111/j.1749-6632.2010.05725.x
https://doi.org/10.1111/j.1749-6632.2010.05725.x