Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Jose R Conejo-Garcia"'
Autor:
Tyler Curiel, Yilun Deng, Aravind Kancharla, Myrna Garcia, Haiyan Bai, Ryan Michael Reyes, Harshita B Gupta, Alvaro S Padron, Anand V R Kornepati, Jose R Conejo-Garcia, Yiji J Liao, Clare J Murray, Carlos Ontiveros, Suresh J Kari
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Tumor intracellular programmed cell death ligand-1 (PDL1) mediates pathologic signals that regulate clinical treatment responses distinctly from surface-expressed PDL1 targeted by αPDL1 immune checkpoint blockade antibodies.Methods We per
Externí odkaz:
https://doaj.org/article/17e6b1fa8654420fb479e0007b231c94
Autor:
Matthew Johnson, Jameel Muzaffar, Xuefeng Wang, Christine H Chung, Jose R Conejo-Garcia, Michael J Schell, Kedar Kirtane, Priyanka Bhateja, Marcelo Bonomi, Feifei Song, Jiannong Li, Sean J Yoder, Jose A Guevara-Patino, James W Rocco, Conor E Steuer, Nabil F Saba
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/5c07de39e3c8402aa41c38e7422c0643
Autor:
Lisa H Butterfield, Howard Streicher, Patrick Hwu, Walter J Storkus, Ahmad A Tarhini, John M Kirkwood, F Stephen Hodi, Vernon K Sondak, Jose R Conejo-Garcia, Sandra J Lee, Aik-Choon Tan, Issam M El Naqa, William A LaFramboise, Arivarasan D Karunamurthy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/32a3715be491424abf49ab6f4cedd4e3
Autor:
Yilun Deng, Aravind Kancharla, Myrna Garcia, Deyi Zhang, Niannian Ji, Neelam Mukherjee, Karen Wheeler, Tyler J Curiel, Robert S Svatek, Ryan Michael Reyes, Harshita B Gupta, Alvaro S Padron, Chenghao Zhang, Anand V R Kornepati, Onur Boyman, Jose R Conejo-Garcia
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Anti-programmed death-ligand 1 (αPD-L1) immunotherapy is approved to treat bladder cancer (BC) but is effective in
Externí odkaz:
https://doaj.org/article/2a231be16e8747f5b3befb1e7bde6cde
Autor:
Eric P. Knott, Emily Y. Kim, Edison Q. Kim, Rochelle Freire, Justin A. Medina, Yujie Wang, Cheng-Bang Chen, Chunjing Wu, Medhi Wangpaichitr, Jose R. Conejo-Garcia, Diane C. Lim
Publikováno v:
Cells, Vol 13, Iss 13, p 1120 (2024)
Understanding tumor–host immune interactions and the mechanisms of lung cancer response to immunotherapy is crucial. Current preclinical models used to study this often fall short of capturing the complexities of human lung cancer and lead to incon
Externí odkaz:
https://doaj.org/article/782ba5392931466f8bb9e186c1d42990
Publikováno v:
Life, Vol 14, Iss 3, p 325 (2024)
Immuno-oncology has traditionally focused on conventional MHC-restricted αβ T cells. Yet, unconventional γδ T cells, which kill tumor cells in an MHC-unrestricted manner, display characteristics of effector activity and stemness without exhaustio
Externí odkaz:
https://doaj.org/article/b19307fe8929452299c70de55b93fa93
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101649- (2022)
Summary: Understanding the heterogenicity of tumor-infiltraing lymphocyte (TIL) populations and the immunobiology in human cancer is a key to establish efficient immunotherapies. Here, we have established a protocol for the characterization of CD8+ T
Externí odkaz:
https://doaj.org/article/3df006057ced4d7f9295ca33ee123e90
Autor:
Ritu Chaudhary, Robbert J.C. Slebos, Leenil C. Noel, Feifei Song, Maria I. Poole, Dirk S. Hoening, Juan C. Hernandez-Prera, Jose R. Conejo-Garcia, Jose A. Guevara-Patino, Xuefeng Wang, Mengyu Xie, Aik Choon Tan, Christine H. Chung
Publikováno v:
Cancer Research Communications. 3:896-907
Head and neck squamous cell carcinoma (HNSCC) has one of the most hypoxic and immunosuppressive tumor microenvironments (TME) among solid tumors. However, there is no proven therapeutic strategy to remodel the TME to be less hypoxic and proinflammato
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The rapid development of single-cell RNA sequencing (scRNA-seq) provides unprecedented opportunities to study the tumor ecosystem that involves a heterogeneous mixture of cell types. However, the majority of previous and current s
Externí odkaz:
https://doaj.org/article/aeb9ef1fd1eb4d15ad3409bf1f0b94e7
Autor:
Cassandra A. Hathaway, Jose R. Conejo-Garcia, Brooke L. Fridley, Bernard Rosner, Daryoush Saeed-Vafa, Carlos Moran Segura, Jonathan V. Nguyen, Jonathan L. Hecht, Naoko Sasamoto, Kathryn L. Terry, Shelley S. Tworoger, Mary K. Townsend
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 32:848-853
Background: Despite the immunogenic nature of many ovarian tumors, treatment with immune checkpoint therapies has not led to substantial improvements in ovarian cancer survival. To advance population-level research on the ovarian tumor immune microen