Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jose P. Lopez-Atalaya"'
Autor:
Elsa Ghirardini, Giulia Sagona, Angel Marquez-Galera, Francesco Calugi, Carmen M. Navarron, Francesco Cacciante, Siwei Chen, Federica Di Vetta, Lorenzo Dadà, Raffaele Mazziotti, Leonardo Lupori, Elena Putignano, Pierre Baldi, Jose P. Lopez-Atalaya, Tommaso Pizzorusso, Laura Baroncelli
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Mutations in the solute carrier family 6-member 8 (Slc6a8) gene, encoding the protein responsible for cellular creatine (Cr) uptake, cause Creatine Transporter Deficiency (CTD), an X-linked neurometabolic disorder presenting with intellectua
Externí odkaz:
https://doaj.org/article/3f49e5cb2fdd44aa8c6228ed37b9bcba
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101121- (2022)
Summary: Bulk-tissue RNA-seq is widely used to dissect variation in gene expression levels across tissues and under different experimental conditions. Here, we introduce a protocol that leverages existing single-cell expression data to deconvolve pat
Externí odkaz:
https://doaj.org/article/85c2a0d7193f41728806e52e915d5b7b
Autor:
Michal Lipinski, Rafael Muñoz-Viana, Beatriz del Blanco, Angel Marquez-Galera, Juan Medrano-Relinque, José M. Caramés, Andrzej A. Szczepankiewicz, Jordi Fernandez-Albert, Carmen M. Navarrón, Roman Olivares, Grzegorz M. Wilczyński, Santiago Canals, Jose P. Lopez-Atalaya, Angel Barco
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene ex
Externí odkaz:
https://doaj.org/article/8d6aa25253f747418d7750e6dad126ba
Autor:
Marilyn Scandaglia, Jose P. Lopez-Atalaya, Alejandro Medrano-Fernandez, Maria T. Lopez-Cascales, Beatriz del Blanco, Michal Lipinski, Eva Benito, Roman Olivares, Shigeki Iwase, Yang Shi, Angel Barco
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 47-59 (2017)
During development, chromatin-modifying enzymes regulate both the timely establishment of cell-type-specific gene programs and the coordinated repression of alternative cell fates. To dissect the role of one such enzyme, the intellectual-disability-l
Externí odkaz:
https://doaj.org/article/0c9ba7d748a641f39fbdc4c38cf5460e
Autor:
Irene Gutierrez-Perez, M. Jordan Rowley, Xiaowen Lyu, Viviana Valadez-Graham, Diana M. Vallejo, Esther Ballesta-Illan, Jose P. Lopez-Atalaya, Isaac Kremsky, Esther Caparros, Victor G. Corces, Maria Dominguez
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2715-2727.e5 (2019)
Summary: Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the ps
Externí odkaz:
https://doaj.org/article/b1134bcf5a3d40e694e695a94bf900ba
Autor:
Deisy Guiretti, Ana Sempere, Jose P. Lopez-Atalaya, Antonio Ferrer-Montiel, Angel Barco, Luis M. Valor
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 190-201 (2016)
Defective epigenetic regulation has been postulated as a possible cause for the extensive and premature transcriptional dysregulation observed in experimental models of Huntington's disease (HD). In this study, we extended our observations in the N17
Externí odkaz:
https://doaj.org/article/8a79db061ed64711bfe003b54a0f396c
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 186-194 (2010)
Rubinstein–Taybi syndrome (RSTS) is a complex autosomal-dominant disease characterized by mental and growth retardation and skeletal abnormalities. A majority of the individuals diagnosed with RSTS carry heterozygous mutation in the gene CREBBP, bu
Externí odkaz:
https://doaj.org/article/e83f11f72e0048fe9e82ed2b720cd694
Autor:
Romana Tomasoni, Raffaella Morini, Jose P Lopez-Atalaya, Irene Corradini, Alice Canzi, Marco Rasile, Cristina Mantovani, Davide Pozzi, Cecilia Garlanda, Alberto Mantovani, Elisabetta Menna, Angel Barco, Michela Matteoli
Publikováno v:
eLife, Vol 6 (2017)
Inflammation modifies risk and/or severity of a variety of brain diseases through still elusive molecular mechanisms. Here we show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, als
Externí odkaz:
https://doaj.org/article/a1efe41b2f8844a1a7fae71785e58503
Autor:
Angel Barco, Rocío González Martínez, Eloisa Herrera, Ángel Márquez Galera, Beatriz Del Blanco, JOSE P. LOPEZ-ATALAYA
Publikováno v:
Cells; Volume 11; Issue 24; Pages: 4118
This article belongs to the Special Issue Neural Stem Cells: Developmental Mechanisms and Disease Modelling.
The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles i
The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles i
Autor:
Aysha María Bhojwani-Cabrera, Carmen M. Navarrón-Izquierdo, Ángel Márquez-Galera, María Royo, Sergio Niñerola, Manuel Alejandro Expósito-Coca, Verónica López-López, Juan Medrano-Relinque, Agnes Gruart, Angel Barco, Sandra Jurado, José María Delgado-García, José P. López-Atalaya
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S270-S271 (2023)
Externí odkaz:
https://doaj.org/article/c3c21d7fd5144287aa37657ebaca9bfb