Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jose P. Leone"'
Autor:
Paolo Tarantino, Julieta Leone, Carlos T. Vallejo, Rachel A. Freedman, Adrienne G. Waks, Olga Martínez-Sáez, Ana Garrido-Castro, Filipa Lynce, Nabihah Tayob, Nancy U. Lin, Sara M. Tolaney, Jose P. Leone
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-4 (2024)
Abstract To evaluate the role of chemotherapy in stage IA triple-negative breast cancer, we conducted a retrospective population-based study including 8601 patients. The use of chemotherapy significantly increased from 2010 to 2019 in patients with T
Externí odkaz:
https://doaj.org/article/1fa3677d68434dd1aa72422112ac6937
Autor:
Jing Ni, Sheheryar Kabraji, Shaozhen Xie, Yanzhi Wang, Peichen Pan, Xiaofang He, Zongming Liu, Jose Palbo Leone, Henry W. Long, Myles A. Brown, Eric P. Winer, Deborah A. R. Dillon, Nancy U. Lin, Jean J. Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
HER2+ breast cancer often develop brain metastases (BCBMs) that are difficult to treat. Here, the authors show that p16INK4A loss in BCBMs from HER2+ breast tumors results in resistance to the HER2 inhibitor Tucatinib, and that CDK4/6 inhibition can
Externí odkaz:
https://doaj.org/article/16bc242049ff4c6ca1e0501ace504822
Autor:
Jose Pablo Leone, Kyrre E. Emblem, Michelle Weitz, Rebecca S. Gelman, Bryan P. Schneider, Rachel A. Freedman, Jerry Younger, Marco C. Pinho, A. Gregory Sorensen, Elizabeth R. Gerstner, Gordon Harris, Ian E. Krop, Daniel Morganstern, Jessica Sohl, Jiani Hu, Elizabeth Kasparian, Eric P. Winer, Nancy U. Lin
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background We aimed to examine the safety and efficacy of bevacizumab and carboplatin in patients with breast cancer brain metastases. Methods We enrolled patients with breast cancer and > 1 measurable new or progressive brain metastasis. Pa
Externí odkaz:
https://doaj.org/article/04de20311a7a49dab14a302103b2d131
Autor:
María M. Gonzalez Lopez Ledesma, Lautaro Sanchez, Diego S. Ojeda, Santiago Oviedo Rouco, Andrés H. Rossi, Augusto Varese, Ignacio Mazzitelli, Carla A. Pascuale, Esteban A. Miglietta, Pamela E. Rodríguez, Horacio M. Pallarés, Guadalupe S. Costa Navarro, Julio J. Caramelo, Paul W. Rothlauf, Zhuoming Liu, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Natali B. Rasetto, Shirley D. Wenker, Lila Y. Ramis, Magalí G. Bialer, María Jose de Leone, C. Esteban Hernando, Luciana Bianchimano, Antonella S. Ríos, María Soledad Treffinger Cienfuegos, Diana R. Rodriguez García, Yesica Longueira, Natalia Laufer, Diego Alvarez, Ana Ceballos, Valeria Ochoa, Cecilia Monzani, Gariela Turk, Melina Salvatori, Jorge Carradori, Katherine Prost, Alejandra Rima, Claudia Varela, Regina Ercole, Rosana I. Toro, Sebastian Gutierrez, Martín Zubieta, Dolores Acuña, Mercedes S. Nabaes Jodar, Carolina Torres, Laura Mojsiejczuk, Mariana Viegas, Pilar Velazquez, Clarisa Testa, Nicolas Kreplak, Marcelo Yanovsky, Sean Whelan, Jorge Geffner, Marina Pifano, Andrea V. Gamarnik
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants in coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal antibody responses and vira
Externí odkaz:
https://doaj.org/article/476503e038aa442f9b66beea37825921
Autor:
Joseph J. Connolly, Laura M. Spring, Alphonse G. Taghian, Michele Gadd, Laura Warren, Ana C. Garrido-Castro, Tari King, Elizabeth A. Mittendorf, Jose P. Leone, Dana L. Casey, Lisa Carey, Tiffany A. Traina, Yara Abdou, Atif Khan, George Plitas, Jean Wright, Cesar Augusto Santa-Maria, Lisa Jacobs, Rachel Blitzblau, E Shelley Hwang, Carey Anders, Ian Krop, Antonio C. Wolff, Alastair M. Thompson, Elyssa Denault, Gaorav Gupta, Alice Ho
Publikováno v:
Cancer Research. 83:OT3-15
Background: The introduction of immune checkpoint inhibitors (ICI) to standard neoadjuvant chemotherapy regimens has been shown to significantly improve outcomes in patients with triple negative breast cancer and is being investigated for high-risk h
Autor:
Julieta Leone, Michael J. Hassett, Rachel Freedman, Sara Tolaney, Noah Graham, Nabihah Tayob, Carlos T. Vallejo, Eric Winer, Nancy U. Lin, Jose P. Leone
Publikováno v:
Cancer Research. 83:PD6-08
Background: In women with hormone receptor-positive (HR+) breast cancer, the risk of distant recurrence and death persists for at least 20 years (y) from diagnosis. The risk of late mortality in men with HR+ breast cancer has not been reported. The a
Autor:
Steffi Oesterreich, Adrian V. Lee, Peter C. Lucas, Esther Elishaev, Adam M. Brufsky, Ronald L. Hamilton, Jose P. Leone, Jens-Uwe Blohmer, Carsten Denkert, Maria M. Karsten, Kurt R. Weiss, Rohit Bhargava, Michelle M. Boisen, Rebecca J. Watters, Amir Bahreini, Ethan S. Sokol, Ryan J. Hartmaier, Nolan Priedigkeit, Ahmed Basudan
Table S1. Clinicopathological characteristics and sample distribution by site Table S2. Primers/probes design for ddPCR (ESR1, EIF2C, AP3P1) Table S3. Raw nanoString counts Table S4. Normalized copy number calls (ER+ samples) Table S5. Normalized cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9e59f5e3d10c1d4f9b6cf3550a23c1
https://doi.org/10.1158/1541-7786.22513387
https://doi.org/10.1158/1541-7786.22513387
Autor:
Steffi Oesterreich, Adrian V. Lee, Peter C. Lucas, Esther Elishaev, Adam M. Brufsky, Ronald L. Hamilton, Jose P. Leone, Jens-Uwe Blohmer, Carsten Denkert, Maria M. Karsten, Kurt R. Weiss, Rohit Bhargava, Michelle M. Boisen, Rebecca J. Watters, Amir Bahreini, Ethan S. Sokol, Ryan J. Hartmaier, Nolan Priedigkeit, Ahmed Basudan
Figure S1: Genomic organization of ESR1 nanoString probes Figure S2: Correlation of ESR1 amplification with mRNA expression Figure S3: ESR1 copy number status in ER+ primary-metastasis pairs Figure S4: Oncoprint visualization of copy number alteratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb4ca70d3e077735a7368e8ee70c5eb
https://doi.org/10.1158/1541-7786.22513390.v1
https://doi.org/10.1158/1541-7786.22513390.v1
Autor:
Jose P Leone, Noah Graham, Julieta Leone, Sara M Tolaney, Bernardo A Leone, Rachel A Freedman, Michael J Hassett, Carlos T Vallejo, Eric P Winer, Nancy U Lin, Nabihah Tayob
Publikováno v:
Cancer Research. 82:P2-10
Background: Triple-negative breast cancer (TNBC) is associated with high risk of distant recurrence and death. At present, our ability to estimate risk of death from causes other than breast cancer is limited. Particularly among elderly patients (pts
Publikováno v:
Cancer Research. 83:PD7-05
Background Brain metastases (BM) is a challenging presentation of breast cancer (BC) and has historically been associated with poor prognosis. The risk of BM is higher in patients (pts) with hormone receptor (HR) negative, human epidermal growth fact