Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jose Navarrete‐Perea"'
Autor:
Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impac
Externí odkaz:
https://doaj.org/article/cd1a101b49ee4dfbb34edecc65790389
Autor:
Aron Gyuris, Jose Navarrete-Perea, Ala Jo, Simona Cristea, Shuang Zhou, Kyle Fraser, Zhiyun Wei, Anna M. Krichevsky, Ralph Weissleder, Hakho Lee, Steve P. Gygi, Al Charest
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3972-3987.e6 (2019)
Summary: Cancer extracellular vesicles (EVs) are highly heterogeneous, which impedes our understanding of their function as intercellular communication agents and biomarkers. To deconstruct this heterogeneity, we analyzed extracellular RNAs (exRNAs)
Externí odkaz:
https://doaj.org/article/5034af0a55cc44c5902e50df63b76e17
Autor:
Sierra N. Cullati, Eric Zhang, Yufan Shan, Rodrigo X. Guillen, Jun-Song Chen, Jose Navarrete-Perea, Zachary C. Elmore, Liping Ren, Steven P. Gygi, Kathleen L. Gould
The CK1 family are conserved serine/threonine kinases with numerous substrates and cellular functions. The fission yeast CK1 orthologues Hhp1 and Hhp2 were first characterized as regulators of DNA repair, but the mechanism(s) by which CK1 activity pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbddb01c7d92d87cb77697c6eed5c34d
https://doi.org/10.1101/2023.04.27.538600
https://doi.org/10.1101/2023.04.27.538600
Autor:
Sierra N. Cullati, Apirat Chaikuad, Jun-Song Chen, Jakob Gebel, Laura Tesmer, Rezart Zhubi, Jose Navarrete-Perea, Rodrigo X. Guillen, Steven P. Gygi, Gerhard Hummer, Volker Dötsch, Stefan Knapp, Kathleen L. Gould
Publikováno v:
Mol Cell
CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe an evolutionarily conserved mechanism of CK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad52b2fdd81b6261a33505ea7376ad98
https://doi.org/10.1096/fasebj.2022.36.s1.0r463
https://doi.org/10.1096/fasebj.2022.36.s1.0r463
Publikováno v:
Proteomics
Reporter ion interference remains a limitation of isobaric tag-based sample multiplexing. Advances in instrumentation and data acquisition modes, such as the recently developed real-time database search (RTS), can reduce interference. However, interf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d93f2825ff681304b1f15455f23dfd4
https://doi.org/10.1002/pmic.202100317
https://doi.org/10.1002/pmic.202100317
Autor:
Devin K. Schweppe, Satendra Prasad, Michael W. Belford, Jose Navarrete-Perea, Derek J. Bailey, Romain Huguet, Mark P. Jedrychowski, Ramin Rad, Graeme McAlister, Susan E. Abbatiello, Eloy R. Wouters, Vlad Zabrouskov, Jean-Jacques Dunyach, João A. Paulo, Steven P. Gygi
Publikováno v:
Analytical Chemistry. 92:4690-4690
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f38dca022d1b7ca45654b850c57bb1
https://doi.org/10.1021/acs.analchem.0c00888
https://doi.org/10.1021/acs.analchem.0c00888
Publikováno v:
eLife, Vol 10 (2021)
Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increas
Externí odkaz:
https://doaj.org/article/9eaf719877654e798fcc33f219285582
Autor:
José Navarrete-Perea, Marta Isasa, Joao A Paulo, Ricardo Corral-Corral, Jeanette Flores-Bautista, Beatriz Hernández-Téllez, Raúl J Bobes, Gladis Fragoso, Edda Sciutto, Xavier Soberón, Steven P Gygi, Juan P Laclette
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005962 (2017)
In human and porcine cysticercosis caused by the tapeworm Taenia solium, the larval stage (cysts) can infest several tissues including the central nervous system (CNS) and the skeletal muscles (SM). The cyst's proteomics changes associated with the t
Externí odkaz:
https://doaj.org/article/618ddda4d2dc4326bddacea1af88d6cd
Autor:
Milka Luna-Nácar, José Navarrete-Perea, Bárbara Moguel, Raúl J Bobes, Juan P Laclette, Julio C Carrero
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156018 (2016)
The cyst stage of Entamoeba histolytica is a promising therapeutic target against human amoebiasis. Our research team previously reported the production in vitro of Cyst-Like Structures (CLS) sharing structural features with cysts, including rounded
Externí odkaz:
https://doaj.org/article/77544642eb8b47e680d420252f7ee386