Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site

Autor: Jean-Didier Maréchal, José-Emilio Sánchez-Aparicio, Igor Tvaroška, Jose N. Varghese, Maria Hrmova, José M. Lluch, Sukanya Luang, V.A. Streltsov, A. Peisley, Marcel Hijnen, Jesús Jiménez-Barbero, Ana Ardá, J.R. Ketudat Cairns, Laura Tiessler-Sala, Carme Rovira, Fernanda Mendoza, Mercedes Alfonso-Prieto, Jaime Rodríguez-Guerra, Sébastien Fort, Laura Masgrau

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09691-z⟩

Substrates associate and products dissociate from enzyme catalytic sites rapidly, which hampers investigations of their trajectories. The high-resolution structure of the native Hordeum exo-hydrolase HvExoI isolated from seedlings reveals that non-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30459d11c55b231244ab87c5844aa4a2
https://ddd.uab.cat/record/223394

Polysaccharide hydrolases in germinated barley and their role in the depolymerization of plant and fungal cell walls

Autor: Maria Hrmova, Geoffrey B. Fincher, Jose N. Varghese, Mitali Banik, Andrew J. Harvey, Thomas P. J. Garrett, Peter B. Høj

Publikováno v: International Journal of Biological Macromolecules. 21:67-72

Cell wall degradation is an important event during endosperm mobilization in the germinated barley grain. A battery of polysaccharide and oligosaccharide hydrolases is required for the complete depolymerization of the arabinoxylans and (1 --> 3,1 -->

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515953ef2095d346f91306e2fa29b3d1
https://doi.org/10.1016/s0141-8130(97)00043-3

Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages

Autor: Yee-Foong Mok, Maree K. Staples, Lynne J. Lawrence, Cameron R. Stewart, Carl H. Schiesser, Anita A. Tseng, Kathryn J. Moore, Geoffrey J. Howlett, Jose N. Varghese

Publikováno v: Biochemistry. 44(25)

The macrophage scavenger receptor CD36 plays a key role in the initiation of atherosclerosis through its ability to bind to and internalize oxidized low-density lipoproteins (oxLDL). Prompted by recent findings that the CD36 receptor also recognizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11a4b41beb3b5c962166ac98cf8948a
https://pubmed.ncbi.nlm.nih.gov/15966734

Spin density and magnetic exchange in a binuclear copper(II) complex

Autor: Andrew R. P. Smith, Brian N. Figgis, Jose N. Varghese, Geoffrey A. Williams, Ronald Mason

Publikováno v: Chemical Physics Letters. 79:366-369

Polarised neutron scattering from single crystals of aquabis(bipyridyl)di-μ-hydroxo-sulphato dicopper(II) provides an experimental spin density synthesis which reflects indirect exchange between the ferromagnetically coupled copper atoms.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e27dc9053bba4f2d5b31b8335bc2b5be
https://doi.org/10.1016/0009-2614(81)80223-0

Electron densities in transition metal complexes: population analysis of polarized neutron diffraction data

Autor: Ronald Mason, Jose N. Varghese

Publikováno v: Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences. 372:1-7

We describe the use of local multipole expansions to parametrize the spin-density distributions in transition metal complexes, derived from Bragg magnetic structure factors, and discuss the determination of ‘local orbital’ populations. The method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9fc9e9e1e1e68382889e275278f5d40
https://doi.org/10.1098/rspa.1980.0098