Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jose N. Onuchic"'
Proteins are the workhorse of life. They are the building infrastructure of living systems; they are the most efficient molecular machines known, and their enzymatic activity is still unmatched in versatility by any artificial system. Perhaps protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973d69158a6050b6e25805486c5eeacb
https://zenodo.org/record/6778287
https://zenodo.org/record/6778287
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious, and transmission involves a series of processes that may be targeted by vaccines and therapeutics. During transmission, host cell invasion is controlled by a large-sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f7eee5c18354078f135b7bf504b2ad
https://doi.org/10.7554/elife.70362
https://doi.org/10.7554/elife.70362
Autor:
Prakash Kulkarni, Vitor B. P. Leite, Susmita Roy, Supriyo Bhattacharyya, Atish Mohanty, Srisairam Achuthan, Divyoj Singh, Rajeswari Appadurai, Govindan Rangarajan, Keith Weninger, John Orban, Anand Srivastava, Mohit Kumar Jolly, Jose N. Onuchic, Vladimir N. Uversky, Ravi Salgia
Publikováno v:
Biophysics Reviews. 3:011306
Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure. Hence, they are often misconceived to present a challenge to Anfinsen's dogma. However, IDPs exist as ensembles that sample a quasi-continuum of rapidly interconverti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02686a9c7e02dd2de4d38fd3fa880f3
https://doi.org/10.1063/5.0080512
https://doi.org/10.1063/5.0080512
Publikováno v:
Biophysical Journal. 121:160a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781306d51fac2823903e013bcec2637a
https://doi.org/10.1016/j.bpj.2021.11.1931
https://doi.org/10.1016/j.bpj.2021.11.1931
Autor:
Vinícius G. Contessoto, Olga Dudchenko, Erez Lieberman Aiden, Peter G. Wolynes, José N. Onuchic, Michele Di Pierro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Within the nucleus, the genome of eukaryotes folds into partially organized three-dimensional structures specific to each organism. Here the authors perform physical simulations to study the genome architecture of Aedes aegypti, which reveal an ensem
Externí odkaz:
https://doaj.org/article/4fc89a1f7ff54765accd8077aab1f76b
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105719- (2023)
Summary: Cancer metastasis relies on an orchestration of traits driven by different interacting functional modules, including metabolism and epithelial-mesenchymal transition (EMT). During metastasis, cancer cells can acquire a hybrid metabolic pheno
Externí odkaz:
https://doaj.org/article/3d41f39474594e20b222c6ac491a3d0b
Autor:
Alexander, Schug, Martin, Weigt, James A, Hoch, Jose N, Onuchic, Terence, Hwa, Hendrik, Szurmant
Publikováno v:
Methods in enzymology. 471
Two-component signal transduction systems enable cells in bacteria, fungi, and plants to react to extracellular stimuli. A sensor histidine kinase (SK) detects such stimuli with its sensor domains and transduces the input signals to a response regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc8b3ece452485c41562a23d7febc5a7
https://pubmed.ncbi.nlm.nih.gov/20946841
https://pubmed.ncbi.nlm.nih.gov/20946841
Autor:
Samuel A. Vilchez Mercedes, Federico Bocci, Mona Ahmed, Ian Eder, Ninghao Zhu, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly, Pak Kin Wong
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Hybrid epithelial/mesenchymal cells (E/M) are key players in aggressive cancer metastasis. It remains a challenge to understand how these cell states, which are mostly non-existent in healthy tissue, become stable phenotypes participating in collecti
Externí odkaz:
https://doaj.org/article/a10c830fc1e94e2190da9ca5b7979327
Autor:
Nancy S, Sung, Jeffrey I, Gordon, George D, Rose, Elizabeth D, Getzoff, Stephen J, Kron, David, Mumford, Jose N, Onuchic, Norbert F, Scherer, DeWitt L, Sumners, Nancy J, Kopell
Publikováno v:
Science (New York, N.Y.). 301(5639)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7f950c930909136aaeb0d4527c5cbbf
https://pubmed.ncbi.nlm.nih.gov/12970550
https://pubmed.ncbi.nlm.nih.gov/12970550
Autor:
Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dua
Externí odkaz:
https://doaj.org/article/4979b2c9fe654e15a019e2b5da2998c8