Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jose N Onuchic"'
Publikováno v:
eLife, Vol 10 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious, and transmission involves a series of processes that may be targeted by vaccines and therapeutics. During transmission, host cell invasion is controlled by a large-sca
Externí odkaz:
https://doaj.org/article/3161795eb02549d0b7f31b0bdc720ca8
Autor:
Ryan R Cheng, Vinicius G Contessoto, Erez Lieberman Aiden, Peter G Wolynes, Michele Di Pierro, Jose N Onuchic
Publikováno v:
eLife, Vol 9 (2020)
Using computer simulations, we generate cell-specific 3D chromosomal structures and compare them to recently published chromatin structures obtained through microscopy. We demonstrate using machine learning and polymer physics simulations that epigen
Externí odkaz:
https://doaj.org/article/dcd8f4691c724d23a58e834aec515630
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005456 (2017)
One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple layers of regulation invol
Externí odkaz:
https://doaj.org/article/0360172bfda54553bbb0ac02de521949
Publikováno v:
F1000Research, Vol 5 (2016)
Experimentally derived structural constraints have been crucial to the implementation of computational models of biomolecular dynamics. For example, not only does crystallography provide essential starting points for molecular simulations but also hi
Externí odkaz:
https://doaj.org/article/9f03ac29b4f042c8a74f461946b0ab99
Proteins are the workhorse of life. They are the building infrastructure of living systems; they are the most efficient molecular machines known, and their enzymatic activity is still unmatched in versatility by any artificial system. Perhaps protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973d69158a6050b6e25805486c5eeacb
https://zenodo.org/record/6778287
https://zenodo.org/record/6778287
Autor:
Prakash Kulkarni, Vitor B. P. Leite, Susmita Roy, Supriyo Bhattacharyya, Atish Mohanty, Srisairam Achuthan, Divyoj Singh, Rajeswari Appadurai, Govindan Rangarajan, Keith Weninger, John Orban, Anand Srivastava, Mohit Kumar Jolly, Jose N. Onuchic, Vladimir N. Uversky, Ravi Salgia
Publikováno v:
Biophysics Reviews. 3:011306
Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure. Hence, they are often misconceived to present a challenge to Anfinsen's dogma. However, IDPs exist as ensembles that sample a quasi-continuum of rapidly interconverti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02686a9c7e02dd2de4d38fd3fa880f3
https://doi.org/10.1063/5.0080512
https://doi.org/10.1063/5.0080512
Publikováno v:
Biophysical Journal. 121:160a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781306d51fac2823903e013bcec2637a
https://doi.org/10.1016/j.bpj.2021.11.1931
https://doi.org/10.1016/j.bpj.2021.11.1931
Publikováno v:
eLife, Vol 12 (2024)
Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of oligopotent endothelial cells i
Externí odkaz:
https://doaj.org/article/dc2a6080020640a4bc2f7473d8af19b8
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1011013 (2023)
A model for DNA and nucleosomes is introduced with the goal of studying chromosomes from a single base level all the way to higher-order chromatin structures. This model, dubbed the Widely Editable Chromatin Model (WEChroM), reproduces the complex me
Externí odkaz:
https://doaj.org/article/b07c464eba704d18a2558e12dd7e655f
Autor:
Alexander, Schug, Martin, Weigt, James A, Hoch, Jose N, Onuchic, Terence, Hwa, Hendrik, Szurmant
Publikováno v:
Methods in enzymology. 471
Two-component signal transduction systems enable cells in bacteria, fungi, and plants to react to extracellular stimuli. A sensor histidine kinase (SK) detects such stimuli with its sensor domains and transduces the input signals to a response regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc8b3ece452485c41562a23d7febc5a7
https://pubmed.ncbi.nlm.nih.gov/20946841
https://pubmed.ncbi.nlm.nih.gov/20946841