Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jose Miguel Minguez"'
Autor:
Pengbin Li, Ping Huang, Shaohui Yang, Ruiheng Zhu, Jose Miguel Minguez, Zhongbo Li, Sarah J. Ryan, Baoquan Sun, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 24:1938-1947
We have developed a continuous flow method to enable rapid scaleup of an enantioenriched benzodioxan intermediate. We propose that the reaction proceeds through an intramolecular SNAr cyclization. ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9766ccb69f7a1d17911eb4504b89e6
https://doi.org/10.1021/acs.oprd.9b00499
https://doi.org/10.1021/acs.oprd.9b00499
Autor:
David E. Timm, Leonard N. Boggs, Brian Michael Mathes, Yuan Shi, Mario Barberis, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Pablo Garcia-Losada, Jose Miguel Minguez, Leonard L. Winneroski, Jon A. Erickson, Richard A. Brier, Anthony R. Borders, Stephanie L. Stout, Porter Warren J, Zoran Rankovic, Jose Eduardo Lopez, Erik James Hembre, James E. Audia, Jorg Hendle, James P. Beck, Steven James Green, Brian Morgan Watson, Patrick C. May, Robert D. Boyer
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115194
Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer's disease. We previously reported the fragment-based discovery of LY2811376, the first BACE1 inhibitor reported to dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686975880a947f8f81325a11d876e66b
https://doi.org/10.1016/j.bmc.2019.115194
https://doi.org/10.1016/j.bmc.2019.115194