Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jose Miguel Cosgaya"'
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17023 (2011)
BACKGROUND: Schwann cells (SCs) are the cell type responsible for the formation of the myelin sheath in the peripheral nervous system (PNS). As retinoic acid (RA) and other retinoids have a profound effect as regulators of the myelination program, we
Externí odkaz:
https://doaj.org/article/23688ecb841b45abb8f57f867785425f
Autor:
Núria Casals, Marta Palomo-Guerrero, Alejandro Gella, Jose Miguel Cosgaya, Carmen Grijota-Martínez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Schwann cells (SCs) play a key role in peripheral nerve regeneration. After damage, they respond acquiring a repair phenotype that allows them to proliferate, migrate and redirect axonal growth. Previous studies have shown that Uridine-5'-Triphosphat
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Breast cancer is one of the most lethal malignancies for women. Retinoic acid (RA) and double-stranded RNA (dsRNA) are considered signaling molecules with potential anticancer activity. RA, co-administered with the dsRNA mimic polyinosinic-polycytidy
Publikováno v:
Glia. 58:1451-1464
Understanding the mechanisms that control myelin formation is essential for the development of demyelinating diseases treatments. All-trans-retinoic acid (RA) plays an essential role during the development of the nervous system as a potent regulator
Autor:
Ana Aranda, Jose Miguel Cosgaya
Publikováno v:
Journal of Neurochemistry. 76:661-671
Nerve growth factor (NGF) and retinoic acid (RA) exert important actions on PC12 cells. We have previously shown that incubation with NGF induces retinoic acid receptor β (RARβ) binding to a hormone response element in PC12 cells. In this study we
Autor:
Jose Miguel Cosgaya, Eric M. Shooter
Publikováno v:
Journal of Neurochemistry. 79:391-399
Nerve growth factor (NGF) regulates the activity of the transcription factor NF-κB (nuclear factor-κB) through its low affinity receptor, p75. In the present study we found that NGF binding to p75 induces nuclear translocation of p65 and increases
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Neurotrophins transmit signals retrogradely from synapses to cell bodies by two different types of surface receptors, p75NTR and Trks. Compared to TrkA, the function of p75NTR in nerve growth factor (NGF) endocytosis is less clear, and it is unknown
Autor:
Jonah R. Chan, Y.J. Wu, Alex Krüttgen, Jens Carsten Möller, Jose Miguel Cosgaya, D. Shine, Eric M. Shooter
Publikováno v:
Journal of Neuroscience Research. 75:825-834
Neurotrophins (NTs) play an important role in the modulation of synaptic transmission and in morphological changes in synaptic structures. Although there is agreement that brain-derived neurotrophic factor (BDNF) is sorted to large dense-core vesicle
Publikováno v:
Science. 298:1245-1248
Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75 NTR . Neurotrophins are key mediators of peripheral nervous system myelination. Our results show that myelin formation is inhibite
Autor:
Sushama Varma, Jose Miguel Cosgaya, Y.J. Wu, Paul S. Buckmaster, C Suri, Ravi J Tolwani, Eric M. Shooter
Publikováno v:
Neuroscience. 114:795-805
There is increasing evidence that brain-derived neurotrophic factor (BDNF) modulates synaptic and morphological plasticity in the developing and mature nervous system. Plasticity may be modulated partially by BDNF's effects on dendritic structure. Ut