Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jose Mario Isas"'
Autor:
Alan K. Okada, Kazuki Teranishi, Mark R. Ambroso, Jose Mario Isas, Elena Vazquez-Sarandeses, Joo-Yeun Lee, Arthur Alves Melo, Priyatama Pandey, Daniel Merken, Leona Berndt, Michael Lammers, Oliver Daumke, Karen Chang, Ian S. Haworth, Ralf Langen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins. Here, the authors map lysine acetylation predominantly in membrane-intera
Externí odkaz:
https://doaj.org/article/969a6247f4f548d799fa269799855a27
Autor:
Leona Berndt, Elena Vazquez-Sarandeses, Arthur Alves de Melo, Kazuki Teranishi, Ralf Langen, Mark R. Ambroso, Michael Lammers, Daniel Merken, Oliver Daumke, Ian S. Haworth, Joo-Yeun Lee, Alan K Okada, Jose Mario Isas, Karen Chang, Priyatama Pandey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates membrane protein function. Here, we use bioinformatics, biophysical analysis of recombinant proteins, live-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f247f0d56d38fe5745b3672e36f114f
https://doaj.org/article/969a6247f4f548d799fa269799855a27
https://doaj.org/article/969a6247f4f548d799fa269799855a27
Autor:
Anjalika Chongtham, Ali Khoshnan, Anoop Rawat, Ralf Langen, Nitin K. Pandey, Jung Hyun Yoo, Mary B. Kennedy, Jose Mario Isas, Tara L Mastro
Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeats in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf8fa0f42ec70dc489baafb538f0610b
https://doi.org/10.1101/2021.04.16.440200
https://doi.org/10.1101/2021.04.16.440200
Autor:
Ralf Langen, Applebaum A, Kazuki Teranishi, Alan Okada, Jose Mario Isas, Ansgar B. Siemer, Nitin K. Pandey, Franziska Meier
The first exon of the huntingtin protein (HTTex1) important in Huntington’s Disease (HD) can form cross-β fibrils of varying toxicity. We find that the difference between these fibrils is the degree of entanglement and dynamics of the C-terminal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41777e8b1ea6f7b00c5197d4a2f942e9
https://doi.org/10.1101/703769
https://doi.org/10.1101/703769
Autor:
Jose Mario Isas, Jonathan King, Wah Chiu, Michele C. Darrow, Jesús G. Galaz-Montoya, Michael F. Schmid, Ralf Langen, Oksana A. Sergeeva
Publikováno v:
The Journal of biological chemistry. 290(28)
Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5afec870621b7c8a9f271d52e7ffa57
https://pubmed.ncbi.nlm.nih.gov/25995452
https://pubmed.ncbi.nlm.nih.gov/25995452
Publikováno v:
Journal of Clinical Investigation. 116:378-385
Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50337995602d1f3f9c165364a1d220b0
https://doi.org/10.1172/jci25843
https://doi.org/10.1172/jci25843
Autor:
Prabhavati B. Hegde, Yujin E. Kim, Jose Mario Isas, Harry T. Haigler, Christine C. Jao, Ralf Langen
Publikováno v:
Biochemistry. 44:16435-16444
Annexins are a family of soluble proteins that can undergo reversible Ca 2 + -dependent interaction with the interfacial region of phospholipid membranes. The helical hairpins on the convex face of the crystal structure ofsoluble annexins are propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d5d8f769ea53de8ef97194ffc0ed01
https://doi.org/10.1021/bi051751m
https://doi.org/10.1021/bi051751m
Autor:
Christine C. Jao, Darshana R. Patel, Ralf Langen, Jose Mario Isas, William S. Mailliard, Harry T. Haigler
Publikováno v:
Biochemistry. 40:7054-7060
Annexins (ANXs) are a superfamily of proteins whose functional hallmark is Ca2+-dependent binding to anionic phospholipids. Their core domains are usually composed of a 4-fold repeat of a conserved amino acid sequence, with each repeat containing a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d7d3369d3c38aba8bb77b700b42570
https://doi.org/10.1021/bi010345+
https://doi.org/10.1021/bi010345+
Autor:
Benjamin R. Capraro, Michael C. Heinrich, Jose Mario Isas, Tobias Baumgart, Aiwei Tian, Ralf Langen
Biological membrane functions are coupled to membrane curvature, the regulation of which often involves membrane-associated proteins. The membrane-binding N-terminal amphipathic helix-containing BIN/Amphiphysin/Rvs (N-BAR) domain of amphiphysin is im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d603e9ecf7d94f8afa2ad712edfaca
https://europepmc.org/articles/PMC3679405/
https://europepmc.org/articles/PMC3679405/
Autor:
Jose Mario Isas, Vikram K. Bhatia, Alasdair C. Steven, Jitka Petrlova, Christine C. Jao, Naoko Mizuno, Dimitrios Stamou, Ralf Langen, John C. Voss, Martin Borch Jensen, Jobin Varkey
Synucleins and apolipoproteins have been implicated in a number of membrane and lipid trafficking events. Lipid interaction for both types of proteins is mediated by 11 amino acid repeats that form amphipathic helices. This similarity suggests that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7c3d7ecc6d92c43f155dd63953ba02
https://europepmc.org/articles/PMC2952250/
https://europepmc.org/articles/PMC2952250/