Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jose Mario Bello Pineda"'
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Jose Mario Bello Pineda, Robert K. Bradley
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood. Results We describe an unbiased
Externí odkaz:
https://doaj.org/article/3e221b88df34409f92e5f01950f1eca2
Publikováno v:
eLife, Vol 12 (2024)
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation tha
Externí odkaz:
https://doaj.org/article/fd7d1d0ccf2346e9aa165a47751997e3
Autor:
Tomas Mustelin, Alison Bays, Rayan Najjar, Noga Rogel, Jose Mario Bello Pineda, Xiaoxing Wang, Megan Tran
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 1 (2024)
Objectives To illuminate the poorly understood aetiology of SLE by comparing the gene expression profile of SLE neutrophils with that of neutrophils from patients infected by SARS-CoV-2, a disease (COVID-19) with well-defined antigens and a similar t
Externí odkaz:
https://doaj.org/article/4199bb49b79b41488a14a17eb1ec7704
Autor:
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SR
Externí odkaz:
https://doaj.org/article/7052b61a50574159ad243b8dd55f38e5
Autor:
Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Publikováno v:
eLife, Vol 10 (2021)
Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex. By rapid and selective
Externí odkaz:
https://doaj.org/article/2d4ce356cf4040e3ac6e28874adae061
Autor:
Samuel Frederick Mock Hart, Jose Mario Bello Pineda, Chi-Chun Chen, Robin Green, Wenying Shou
Publikováno v:
eLife, Vol 8 (2019)
Mutualisms can be promoted by pleiotropic win-win mutations which directly benefit self (self-serving) and partner (partner-serving). Intuitively, partner-serving phenotype could be quantified as an individual’s benefit supply rate to partners. Her
Externí odkaz:
https://doaj.org/article/7b9943e348ad48d594042d1875c72840
Autor:
Samuel F M Hart, Hanbing Mi, Robin Green, Li Xie, Jose Mario Bello Pineda, Babak Momeni, Wenying Shou
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000135 (2019)
Quantitative modeling is useful for predicting behaviors of a system and for rationally constructing or modifying the system. The predictive power of a model relies on accurate quantification of model parameters. Here, we illustrate challenges in par
Externí odkaz:
https://doaj.org/article/93e5b934739b43c2b70739772646ede9
Autor:
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward
Publikováno v:
JCI Insight.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4310bb059ba7acc74008b1bef7cde8a
https://doi.org/10.1172/jci.insight.167270
https://doi.org/10.1172/jci.insight.167270
Autor:
Khrystyna North, Salima Benbarche, Bo Liu, Joseph Pangallo, Sisi Chen, Maximilian Stahl, Jan Philipp Bewersdorf, Robert F. Stanley, Caroline Erickson, Hana Cho, Jose Mario Bello Pineda, James D. Thomas, Jacob T. Polaski, Andrea E. Belleville, Austin M. Gabel, Dylan B. Udy, Olivier Humbert, Hans-Peter Kiem, Omar Abdel-Wahab, Robert K. Bradley
Publikováno v:
Nature Biotechnology. 40:1103-1113
Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors. Here, we describe a method to harness this abnormal splicing activity to drive splicing factor mutation-dependent gene expression to selectively eliminate tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9303fcac634bc47d4f428a22acb57a
https://doi.org/10.1038/s41587-022-01224-2
https://doi.org/10.1038/s41587-022-01224-2
Autor:
Benjamin H. Durham, Yasutaka Hayashi, Frank McCormick, Sanjoy Mehta, Atsushi Tanaka, Hiromi Yamazaki, Ettaib El Marabti, Chie Fukui, Ralph Garippa, Bo Liu, Guo-Liang Chew, Sydney X. Lu, Jacob T. Polaski, Alex Penson, Justin Taylor, Eric Wang, Sisi Chen, Daichi Inoue, Simon J. Hogg, Daniel Zakheim, Caroline Erickson, Jose Mario Bello Pineda, Miki Fukumoto, Pau Castel, Omar Abdel-Wahab, Susumu Kobayashi, Katherine Knorr, Robert K. Bradley
Publikováno v:
Nature genetics, vol 53, iss 5
Nature genetics
Nature genetics
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977cfa901744455e3cb0d97f4b8e8476
https://doi.org/10.1038/s41588-021-00828-9
https://doi.org/10.1038/s41588-021-00828-9