Výsledky vyhledávání - "Jose Manuel Martin"

Akademický článek

Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing

Autor: Alexandra Zara Rozalen, Jose Manuel Martin, Rithika Rajendran, Maneesh Jain, Victor E. Nava

Publikováno v: Current Oncology, Vol 31, Iss 3, Pp 1556-1561 (2024)

Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathologica

Externí odkaz: https://doaj.org/article/27701fa1366f4de2a9f61414072dd8f3

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Akademický článek

Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on possibilities unleashed by mix-and-inject serial crystallography (MISC) at X-ray f

Externí odkaz: https://doaj.org/article/50042ef4cec14678ac809352eb19f238

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Akademický článek

Chimeric VLPs Bearing VP60 from Two Serotypes of Rabbit Haemorrhagic Disease Virus Are Protective against Both Viruses

Autor: Kevin P. Dalton, Carmen Alvarado, Edel Reytor, Maria del Carmen Nuñez, Ana Podadera, Diego Martínez-Alonso, Jose Manuel Martin Alonso, Ines Nicieza, Silvia Gómez-Sebastián, Romy M. Dalton, Francisco Parra, José M. Escribano

Publikováno v: Vaccines, Vol 9, Iss 9, p 1005 (2021)

The VP60 capsid protein from rabbit haemorrhagic disease virus (RHDV), the causative agent of one of the most economically important disease in rabbits worldwide, forms virus-like particles (VLPs) when expressed using heterologous protein expression

Externí odkaz: https://doaj.org/article/53641f53c28d4f8384e69128078ff137

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Akademický článek

A Reliable and Standardizable Differential PCR and qPCR Methodology Assesses HER2 Gene Amplification in Gastric Cancer

Autor: Ignacio Juarez, Juan Francisco Toro-Fernandez, Christian Vaquero-Yuste, Marta Molina-Alejandre, Inmaculada Lasa, Remedios Gomez, Adela Lopez, Jose Manuel Martin-Villa, Alberto Gutierrez

Publikováno v: Biology, Vol 10, Iss 6, p 516 (2021)

We have applied two PCR techniques, differential PCR (diffPCR) and qPCR for the identification of HER2 gene amplifications in genomic DNA of tumor and distal gastric samples from patients with gastric cancer. The diffPCR technique consists of the sim

Externí odkaz: https://doaj.org/article/9561f4cbc88e401688b0fe7a7c67c94f

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Akademický článek

Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation.

Autor: Julio Bacarizo, Sergio Martinez-Rodriguez, Jose Manuel Martin-Garcia, Montserrat Andujar-Sanchez, Emilia Ortiz-Salmeron, Jose Luis Neira, Ana Camara-Artigas

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113224 (2014)

The SH3 domain of the c-Src tyrosine kinase (c-Src-SH3) aggregates to form intertwined dimers and amyloid fibrils at mild acid pHs. In this work, we show that a single mutation of residue Gln128 of this SH3 domain has a significant effect on: (i) its

Externí odkaz: https://doaj.org/article/4b21d65c5fdc4f37b551823aec7a970c

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