Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jose Manuel Garcia-Manteiga"'
Autor:
Alisia Madè, Alessia Bibi, Jose Manuel Garcia-Manteiga, Anna Sofia Tascini, Santiago Nicolas Piella, Roman Tikhomirov, Christine Voellenkle, Carlo Gaetano, Przemyslaw Leszek, Serenella Castelvecchio, Lorenzo Menicanti, Fabio Martelli, Simona Greco
Publikováno v:
Cells, Vol 12, Iss 21, p 2578 (2023)
Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs (miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs can interact with miRNAs, influencing their specific mRNA targets’ levels and shapi
Externí odkaz:
https://doaj.org/article/ab68ca85e619417b8427ed877fe9797e
Autor:
Beatrice Cardinali, Claudia Provenzano, Mariapaola Izzo, Christine Voellenkle, Jonathan Battistini, Georgios Strimpakos, Elisabetta Golini, Silvia Mandillo, Ferdinando Scavizzi, Marcello Raspa, Alessandra Perfetti, Denisa Baci, Dejan Lazarevic, Jose Manuel Garcia-Manteiga, Geneviève Gourdon, Fabio Martelli, Germana Falcone
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 184-199 (2022)
CRISPR/Cas9-mediated therapeutic gene editing is a promising technology for durable treatment of incurable monogenic diseases such as myotonic dystrophies. Gene-editing approaches have been recently applied to in vitro and in vivo models of myotonic
Externí odkaz:
https://doaj.org/article/5d433c05d99644d685e8e224594c7bdb
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
Autor:
Massimo Alfano, Anna Sofia Tascini, Filippo Pederzoli, Irene Locatelli, Manuela Nebuloni, Francesca Giannese, Jose Manuel Garcia-Manteiga, Giovanni Tonon, Giada Amodio, Silvia Gregori, Alessandra Agresti, Francesco Montorsi, Andrea Salonia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here the authors perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes
Externí odkaz:
https://doaj.org/article/72d44dea6e06424a96786fa8a4b23932
Autor:
Ilaria Castiglioni, Roberta Caccia, Jose Manuel Garcia-Manteiga, Giulia Ferri, Giuseppina Caretti, Ivan Molineris, Kenichi Nishioka, Davide Gabellini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myoblast fusion in skeletal muscle is a complex process but how this is regulated is unclear. Here, the authors identify Ash1L, a histone methyltransferase, as modulating myoblast fusion via activation of the myogenesis gene Cdon, and observe decreas
Externí odkaz:
https://doaj.org/article/2ba6d0377f3f4bbb974cf9e23ced4e21
Autor:
Martin Pecherstorfer, Heng Mei, Yu Hu, Klaus Podar, Chunyan Sun, Judith Lind, Martin Sattler, Qinyue Jiang, Fengjuan Fan, Erwin F. Wagner, Eugenio Morelli, Anja Seckinger, Sonia Vallet, Stefano Malvestiti, Latifa Bakiri, Andreas Stadlbauer, Giovanni Tonon, Hartmut Goldschmidt, Dirk Jaeger, Jose Manuel Garcia-Manteiga, Dirk Hose, Pierfrancesco Tassone
Publikováno v:
Leukemia
Bone marrow (BM) angiogenesis significantly influences disease progression in multiple myeloma (MM) patients and correlates with adverse prognosis. The present study shows a statistically significant correlation of the AP-1 family member JunB with VE
Autor:
Jose Manuel Garcia-Manteiga, Georgios Strimpakos, Christine Voellenkle, Geneviève Gourdon, Beatrice Cardinali, Germana Falcone, Silvia Mandillo, Claudia Provenzano, Marcello Raspa, Denisa Baci, Ferdinando Scavizzi, Mariapaola Izzo, Alessandra Perfetti, Dejan Lazarevic, Jonathan Battistini, Fabio Martelli, Elisabetta Golini
Publikováno v:
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2022, 27, pp.184-199. ⟨10.1016/j.omtn.2021.11.024⟩
Molecular Therapy. Nucleic Acids
MOLECULAR THERAPY-NUCLEIC ACIDS (2021). doi:10.1016/j.omtn.2021.11.024
info:cnr-pdr/source/autori:Cardinali B(1), Provenzano C(1), Izzo M(1), Voellenkle C(2), Battistini J(1), Strimpakos G(1), Golini E(1), Mandillo S(1), Scavizzi F(1), Raspa M(1), Perfetti A(2), Baci D(2), Lazarevic D(3), Garcia-Manteiga JM(3), Gourdon G(4), Martelli F(2), Falcone G(1)/titolo:Time-controlled and muscle-specific CRISPR%2FCas9 mediated deletion of CTG-repeat expansion in the DMPK gene/doi:10.1016%2Fj.omtn.2021.11.024/rivista:MOLECULAR THERAPY-NUCLEIC ACIDS/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Molecular Therapy: Nucleic Acids, Vol 27, Iss, Pp 184-199 (2022)
Molecular Therapy-Nucleic Acids, 2022, 27, pp.184-199. ⟨10.1016/j.omtn.2021.11.024⟩
Molecular Therapy-Nucleic Acids, Elsevier, 2022, 27, pp.184-199. ⟨10.1016/j.omtn.2021.11.024⟩
Molecular Therapy. Nucleic Acids
MOLECULAR THERAPY-NUCLEIC ACIDS (2021). doi:10.1016/j.omtn.2021.11.024
info:cnr-pdr/source/autori:Cardinali B(1), Provenzano C(1), Izzo M(1), Voellenkle C(2), Battistini J(1), Strimpakos G(1), Golini E(1), Mandillo S(1), Scavizzi F(1), Raspa M(1), Perfetti A(2), Baci D(2), Lazarevic D(3), Garcia-Manteiga JM(3), Gourdon G(4), Martelli F(2), Falcone G(1)/titolo:Time-controlled and muscle-specific CRISPR%2FCas9 mediated deletion of CTG-repeat expansion in the DMPK gene/doi:10.1016%2Fj.omtn.2021.11.024/rivista:MOLECULAR THERAPY-NUCLEIC ACIDS/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Molecular Therapy: Nucleic Acids, Vol 27, Iss, Pp 184-199 (2022)
Molecular Therapy-Nucleic Acids, 2022, 27, pp.184-199. ⟨10.1016/j.omtn.2021.11.024⟩
CRISPR/Cas9-mediated therapeutic gene editing is a promising technology for durable treatment of incurable monogenic diseases such as myotonic dystrophies. Gene-editing approaches have been recently applied to in vitro and in vivo models of myotonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04839292564a0ed9916db5edb34c1f8c
https://hal.sorbonne-universite.fr/hal-03753518/document
https://hal.sorbonne-universite.fr/hal-03753518/document
Autor:
Ferdinando Clarelli, S. Bonfiglio, Massimo Filippi, Federica Esposito, A. Protti, Giulia Barbiera, Filippo Martinelli-Boneschi, Vittorio Martinelli, E. Stupka, Silvia Santoro, Elisabetta Mascia, Clara Guaschino, Francesca Giannese, Melissa Sorosina, Dejan Lazarevic, Jose Manuel Garcia-Manteiga, Davide Cittaro
Publikováno v:
Journal of neuroimmunology. 356
Multiple Sclerosis (MS) is caused by a still unknown interplay between genetic and environmental factors. Epigenetics, including DNA methylation, represents a model for environmental factors to influence MS risk. Twenty-six affected and 26 unaffected
Autor:
Michela Riba, Marco Rausa, Melissa Sorosina, Davide Cittaro, Jose Manuel Garcia Manteiga, Antonella Nai, Alessia Pagani, Filippo Martinelli-Boneschi, Elia Stupka, Clara Camaschella, Laura Silvestri
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69694 (2013)
Control of systemic iron homeostasis is interconnected with the inflammatory response through the key iron regulator, the antimicrobial peptide hepcidin. We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inf
Externí odkaz:
https://doaj.org/article/0ed9bab55f9141e189ba62a2958b3215
Autor:
Elisa Lenti, Luca Genovese, Silvia Bianchessi, Aurora Maurizio, Simona Baghai Sain, Alessia di Lillo, Greta Mattavelli, Itamar Harel, Francesca Bernassola, Thomas Hehlgans, Klaus Pfeffer, Mariacristina Crosti, Sergio Abrignani, Sylvia M. Evans, Giovanni Sitia, Nuno Guimarães-Camboa, Vincenzo Russo, Serge A. van de Pavert, Jose Manuel Garcia-Manteiga, Andrea Brendolan
Publikováno v:
Immunity
Immunity, 2022, 55 (4), pp.606-622.e6. ⟨10.1016/j.immuni.2022.03.002⟩
Immunity, 2022, 55 (4), pp.606-622.e6. ⟨10.1016/j.immuni.2022.03.002⟩
International audience; Lymph node (LN) stromal cells play a crucial role in LN development and in supporting adaptive immune responses. However, their origin, differentiation pathways, and transcriptional programs are still elusive. Here, we used li
Autor:
Alessandra Agresti, Lena Hoelzen, Jose Manuel Garcia-Manteiga, Angelica Zocchi, Emanuele Monteleone, Marco Bianchi, Francesca Brambilla
Publikováno v:
Nucleic Acids Research
Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair. Here, we show that in living cells nucleosomes protect DNA from high-energy radiation and reactive o