Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jose Manuel García-Aznar"'
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195820 (2018)
Collagen hydrogels are widely used for in-vitro experiments and tissue engineering applications. Their use has been extended due to their biocompatibility with cells and their capacity to mimic biological tissues; nevertheless their mechanical proper
Externí odkaz:
https://doaj.org/article/defc6d613a964cb3b75ba84b5a20a50e
Publikováno v:
Integrative Biology. 14:212-227
Fibroblasts play an essential role in tissue repair and regeneration as they migrate to wounded areas to secrete and remodel the extracellular matrix. Fibroblasts recognize chemical substances such as growth factors, which enhance their motility towa
Publikováno v:
Jornada de Jóvenes Investigadores del I3A. 9
We aim to define the role of matrix density on tumour growth through a discrete computational framework. We integrate experimental data to characterize the dynamics of individual cellular movement, accounting for the mechanical properties of the ECM,
Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma
Autor:
Elena García-Gareta, Alejandro Calderón-Villalba, Pilar Alamán-Díez, Carlos Gracia Costa, Pedro Enrique Guerrero, Carlota Mur, Ana Rueda Flores, Nerea Olivera Jurjo, Patricia Sancho, María Ángeles Pérez, José Manuel García-Aznar
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151396- (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy that accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the physico-chemical properties of the tumour microenvironment (TME), includin
Externí odkaz:
https://doaj.org/article/54932ba93d894d1a9a1007c7a8a023d2
Publikováno v:
APL Bioengineering, Vol 7, Iss 3, Pp 031501-031501-24 (2023)
Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of
Externí odkaz:
https://doaj.org/article/4989efd441f349db8a01e947a0a773b4
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1262-1271 (2023)
Cancer cells metabolize glucose through metabolic pathways that differ from those used by healthy and differentiated cells. In particular, tumours have been shown to consume more glucose than their healthy counterparts and to use anaerobic metabolic
Externí odkaz:
https://doaj.org/article/9b97e33c16754bc4813f9f07dfe24f6b
Autor:
Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar
Publikováno v:
Cell Adhesion & Migration, Vol 16, Iss 1, Pp 25-64 (2022)
Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells’ ability to migrate relies on many actors. Cells change their migratory strategy b
Externí odkaz:
https://doaj.org/article/652ea42220a04717937c7e7e7c734f60
Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity
Autor:
Eoin McEvoy, Tal Sneh, Emad Moeendarbary, Yousef Javanmardi, Nadia Efimova, Changsong Yang, Gloria E. Marino-Bravante, Xingyu Chen, Jorge Escribano, Fabian Spill, José Manuel Garcia-Aznar, Ashani T. Weeraratna, Tatyana M. Svitkina, Roger D. Kamm, Vivek B. Shenoy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown,
Externí odkaz:
https://doaj.org/article/671f9aee7e3c4eecaf25244cfd1b1fc2
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Macrophages play an essential role in the process of recognition and containment of microbial infections. These immune cells are recruited to infectious sites to reach and phagocytose pathogens. Specifically, in this article, bacteria from t
Externí odkaz:
https://doaj.org/article/70ecc78508334f30be2443a05fffc59f
Autor:
Daniel Camacho-Gomez, Ioritz Sorzabal-Bellido, Carlos Ortiz-de-Solorzano, Jose Manuel Garcia-Aznar, Maria Jose Gomez-Benito
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107164- (2023)
Summary: How cells orchestrate their cellular functions remains a crucial question to unravel how they organize in different patterns. We present a framework based on artificial intelligence to advance the understanding of how cell functions are coor
Externí odkaz:
https://doaj.org/article/c76fcf16a5c34f699bf605935c0e8799