Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jose Malagon Lopez"'
Autor:
Qian Zhang, Paul Bastard, Haiguo Wu, Adrian Gervais, Seiamak Bahram, Sylvain Mayeur, Sharvari Gujja, Anne Thomas, Alexandre Lederle, Julie Helms, Christiane Moog, Xavier Mariette, Alain Viari, Tristan Stemmelen, Christine Carapito, Olivier Hermine, Richard Li, Daniel A. Lidar, Cécile Macquin, Jean Sibilia, Géraldine Laumond, Shweta Kailasan, Leslie Muller, Sabrina Bibi-Triki, Sylvie Schmidt, Aurélie Hirschler, Raony Guimaraes, Michael Simons, Anne Molitor, Francis Schneider, Damien Sanlaville, Thiên-Nga Chamaraux-Tran, Samira Fafi-Kremer, Pierre-Louis Tharaux, Thomas Chittenden, Angélique Pichot, A. Hanauer, Raphael Carapito, Mirjana Radosavljevic, Véronique Rolli, Bernard Goichot, Yvon Ruch, Olivier Collange, Ouria Tahar, Julien Pottecher, Khaldoun Kuteifan, Razieh Mohseninia, Perrine Spinnhirny, Alice Bernard, Bernard Drenou, Jean-Laurent Casanova, Elisa Pin, Jeffrey R. Gulcher, Paul-Michel Mertes, M. Javad Aman, Peter Nilsson, Jose Malagon-Lopez, François Danion, Yves Hansmann, Ferhat Meziani, Maleka Schenck, Nicodème Paul, Annabel Larnicol, Julia Frappier
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2021, pp.1-59. ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, American Association for the Advancement of Science, 2021, ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, 2021, pp.1-59. ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, American Association for the Advancement of Science, 2021, ⟨10.1126/scitranslmed.abj7521⟩
International audience; The etiopathogenesis of critical COVID-19 remains unknown. Indeed given major confounding factors (age and comorbidities), true drivers of this condition have remained elusive. Here, we employ an unprecedented multi-omics anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c8db00ee20c68bec583014ad8e8e4
https://hal.science/hal-03436053
https://hal.science/hal-03436053
Autor:
Carlos Fernández-Hernando, James E. Dahlman, Yang Jiao, Guangxin Li, Esther Lutgens, Jordan S. Pober, Michael Simons, Pascal J. H. Kusters, Binod Aryal, Daniel G. Anderson, Hongye Sun, Alberto Canfrán-Duque, Nicholas A. Cilfone, Jeffrey R. Gulcher, George Tellides, Sharvari Gujja, Pei-Yu Chen, Lele Sun, Rebecca Liu, Alfica Sehgal, Xinbo Zhang, Zheng Wang, Jose Malagon-Lopez, Martin A. Schwartz, Kevin J. Kauffman, Thomas Chittenden, Lingfeng Qin
Publikováno v:
Nature Metabolism, 1(9), 912-926. Springer Berlin
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal shear stress and endothelial lipid retention. A combination of these and, potentially, other factors leads to a chronic inflammatory response in the vessel wall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f565c7c7d33a2e28a9c71dd27d0af0
https://doi.org/10.1038/s42255-019-0102-3
https://doi.org/10.1038/s42255-019-0102-3
Autor:
Jonathan Y. Hsu, Irene Scarfò, Martin J. Aryee, Moira M. Welch, Benjamin P. Kleinstiver, Jose Malagon-Lopez, Russell T. Walton, Kendell Clement, Y. Esther Tak, Marcela V. Maus, Alexander A. Sousa, Joy E. Horng, J. Keith Joung, Luca Pinello
Publikováno v:
Nature biotechnology
Broad use of CRISPR-Cas12a (formerly Cpf1) nucleases1 has been hindered by the requirement for an extended TTTV protospacer adjacent motif (PAM)2. To address this limitation, we engineered an enhanced Acidaminococcus sp. Cas12a variant (enAsCas12a) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b206a63656f9c96786b756d8eb274305
https://doi.org/10.1038/s41587-018-0011-0
https://doi.org/10.1038/s41587-018-0011-0
Autor:
Frank Seeliger, Jimmy A. Guo, Luca Pinello, Mohammad Bohlooly-Y, Roberto Nitsch, Lorenz M. Mayr, Shengdar Q. Tsai, Mick D. Fellows, Pinar Akcakaya, Marcello Maresca, Jose Malagon-Lopez, Alba Carreras, Mikael Bjursell, J. Keith Joung, Nhu T. Nguyen, Mike Firth, Sara P. Garcia, Kendell Clement, Martin J. Aryee, Michelle J. Porritt, Tania Baccega, Maggie L. Bobbin
Publikováno v:
Nature
CRISPR–Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1–6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af450eb5d0a837ac895b4df97292f10b
http://europepmc.org/articles/PMC6194229
http://europepmc.org/articles/PMC6194229
Autor:
Shengdar Q. Tsai, Jose Malagon-Lopez, Martin J. Aryee, Ved V Topkar, Nhu T. Nguyen, J. Keith Joung
Publikováno v:
Nature methods
Sensitive detection of off-target effects is important for translating CRISPR-Cas9 nucleases into human therapeutics. In vitro biochemical methods for finding off-targets offer the potential advantages of greater reproducibility and scalability while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a687f8619a3d185b93deeb28a868e8
http://europepmc.org/articles/PMC5924695
http://europepmc.org/articles/PMC5924695
Autor:
Murat Karabacak, Leah J. Damon, Andrew S. Liss, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Robert Morris, Daniel A. Haber, Mauro Di Pilato, Francesca Bersani, Jose Malagon-Lopez, Anupriya S. Kulkarni, Eric Tai, Nicole Vincent Jordan, Julia Philipp, Melissa Choz, A. W. K. Liu, Vikram Deshpande, Kristina Xega, Miguel Rivera, Joseph W. Franses, Johannes Kreuzer, Cyril H. Benes, Myriam Boukhali, Martin J. Aryee, Kevin D. Vo, Oliver Schilling, Francesco Marangoni, Matteo Ligorio, Adam Langenbucher, Sandra Misale, Srinjoy Sil, Michael S. Lawrence, Kshitij S. Arora, Wilhelm Haas, Linda T. Nieman, Vishal Thapar, Mihir Rajurkar, Chittampalli Yashaswini, Carlos Fernandez-del-Castillo, Cristina R. Ferrone, Niyati Desai, Elad Horwitz, David T. Ting, Shyamala Maheswaran, Ulrich F. Wellner, Neelima K.C. Magnus, Azfar Neyaz
Publikováno v:
Cell
Cell, vol 178, iss 1
Cell, vol 178, iss 1
Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8f16847960fab080e82c78f98d5029
http://hdl.handle.net/2318/1794764
http://hdl.handle.net/2318/1794764
Autor:
Martin J. Aryee, Luca Pinello, Russell T. Walton, Jose Malagon-Lopez, Kendell Clement, Marcela V. Maus, Y. Esther Tak, J. Keith Joung, Moira M. Welch, Jonathan Y. Hsu, Alexander A. Sousa, Benjamin P. Kleinstiver, Joy E. Horng, Irene Scarfò
Publikováno v:
Nature Biotechnology. 38:901-901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756491e981cac86605e410c7f634a744
https://doi.org/10.1038/s41587-020-0587-z
https://doi.org/10.1038/s41587-020-0587-z
Autor:
J. Keith Joung, Cicera R. Lazzarotto, Martin J. Aryee, Nhu T. Nguyen, Jose Malagon-Lopez, Xing Tang, Jimmy A. Guo, Shengdar Q. Tsai
Publikováno v:
Nature protocols. 13(11)
Circularization for in vitro reporting of cleavage effects by sequencing (CIRCLE-seq) is a sensitive and unbiased method for defining the genome-wide activity (on-target and off-target) of CRISPR–Cas9 nucleases by selective sequencing of nuclease-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175b154b436cf16686a122f5d4a3db8c
https://pubmed.ncbi.nlm.nih.gov/30341435
https://pubmed.ncbi.nlm.nih.gov/30341435
Autor:
Luca Pinello, M. Kendell Clement, Mikael Bjursell, Michelle J. Porritt, Mohammad Bohlooly-Y, Lorenz M. Mayr, Tania Baccega, Jimmy A. Guo, Pinar Akcakaya, Martin J. Aryee, J. Keith Joung, Jose Malagon Lopez, Mick D. Fellows, Frank Seeliger, Maggie L. Bobbin, Marcello Maresca, Shengdar Q. Tsai, Roberto Nitsch, Nhu T. Nguyen, Alba Carreras, Mike Firth, Sara P. Garcia
CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics1–5 but identifying unwanted off-target mutations remains an important requirement for clinical translation6, 7. For ex vivo therapeutic applications, previously pub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecbdcbc3134b6540f2cb620ed94cb75
https://doi.org/10.1101/272724
https://doi.org/10.1101/272724
Autor:
Miguel Rivera, Cyril H. Benes, Melissa Choz, Matteo Ligorio, Carlos Fernandez-del Castillo, Julia Philipp, Vikram Deshpande, Shyamala Maheswaran, Linda T. Nieman, Mihir Rajurkar, Francesca Bersani, Eric Tai, Vishal Thapar, Jose Malagon-Lopez, Joseph W. Franses, Daniel A. Haber, Nicole Vincent Jordan, Mauro Di Pilato, Leah J. Damon, Martin J. Aryee, Kevin D. Vo, Kristina Xega, Anupriya S. Kulkarni, Chittampalli Yashaswini, Johannes Kreuzer, Myriam Boukhali, Srinjoy Sil, Robert Morris, Cristina R. Ferrone, Kshitij S. Arora, David T. Ting, Niyati Desai, Wilhelm Haas, Murat Karabacak, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Sandra Misale, Francesco Marangoni
Publikováno v:
SSRN Electronic Journal.
Single cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single cell phenotypes have not been well defined. Combining single cell RNA and protein analytics in pancreatic cancer (PDAC) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f4c3860b59069603e9defcf73551fdb
https://doi.org/10.2139/ssrn.3249464
https://doi.org/10.2139/ssrn.3249464