Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jose M.M. Caaveiro"'
Autor:
Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, José L. Nieva
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102987- (2021)
Summary: Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the conserved Membrane pr
Externí odkaz:
https://doaj.org/article/f69c2aef00f544b7909cd6e9049a9b2c
Autor:
Seisho Kinoshita, Makoto Nakakido, Chinatsu Mori, Daisuke Kuroda, Jose M.M. Caaveiro, Kouhei Tsumoto
Publikováno v:
Protein science : a publication of the Protein Society. 31(11)
The camelid single domain antibody, referred to VHH or Nanobody, is considered a versatile tool for various biotechnological and clinical applications because of its favorable biophysical properties. To take advantage of these characteristics and for
Autor:
Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, Jose M.M. Caaveiro, Yuya Yoshida, Shigehiro Ohdo, Naoya Matsunaga, Shinsuke Toba, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Eiji Kawanishi, Akio Ojida
The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The 3C-like protease (3CLpro) is a promising target for COVID-19 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3211d9a85a29f192d163952e4dc2eb41
https://doi.org/10.1101/2022.06.05.494897
https://doi.org/10.1101/2022.06.05.494897
Autor:
Takanori Yokoo, Aki Tanabe, Yoko Yoshida, Jose M.M. Caaveiro, Makoto Nakakido, Yoichiro Ikeda, Yoshihiro Fujimura, Masaneori Matsumoto, Kevin Entzminger, Toshiaki Maruyama, C.J. Okumura, Masaomi Nangaku, Kouhei Tsumoto
Publikováno v:
J Biol Chem
Atypical hemolytic uremic syndrome (aHUS) is a disease associated with dysregulation of the immune complement system, especially of the alternative pathway (AP). Complement factor H (CFH), consisting of 20 domains called complement control protein (C
Autor:
Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M.M. Caaveiro, Yoshito Abe, Tadashi Ueda
Publikováno v:
Biochemical and biophysical research communications. 596
AL amyloidosis is a life-threatening disease characterized by the deposition of amyloidogenic immunoglobulin light chain secreted from clonal plasma cells. Here we established an in-vitro screening system of amyloid inhibition of a variable domain in
Autor:
Sandra Valenciano-Bellido, Jose M.M. Caaveiro, Koldo Morante, Tatyana Sushko, Makoto Nakakido, Satoru Nagatoishi, Kouhei Tsumoto
Publikováno v:
The Journal of biological chemistry. 298(6)
Staphylococcus aureus is a major cause of deadly nosocomial infections, a severe problem fueled by the steady increase of resistant bacteria. The iron surface determinant (Isd) system is a family of proteins that acquire nutritional iron from the hos
Autor:
Takanori Yokoo, Aki Tanabe, Yoko Yoshida, Jose M.M. Caaveiro, Makoto Nakakido, Yoichiro Ikeda, Yoshihiro Fujimura, Masaneori Matsumoto, Kevin Entzminger, Toshiaki Maruyama, C.J. Okumura, Masaomi Nangaku, Kouhei Tsumoto
Publikováno v:
Journal of Biological Chemistry. 298:102262
Autor:
Kaoru Fujimoto, Akinobu Senoo, Satoru Nagatoishi, Daisuke Takahashi, Tadashi Ueda, Kouhei Tsumoto, Jose M.M. Caaveiro
Membrane proteins are critical elements of numerous therapeutic approaches ranging from cancer to bacterial infections. MsbA is a bacterial membrane protein that has received increasing attention as an antibacterial target for its role in the process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376438545554928969c72f326f7884f6
https://doi.org/10.1101/2021.06.15.448612
https://doi.org/10.1101/2021.06.15.448612
Autor:
Saeko Yanaka, Emiko Sano, Norio Naruse, Kin-ichiro Miura, Mutsumi Futatsumori-Sugai, Jose M.M. Caaveiro, Kouhei Tsumoto
Publikováno v:
Journal of Biological Chemistry. 286:8085-8093
Human interleukin-11 (hIL-11) is a pleiotropic cytokine administered to patients with low platelet counts. From a structural point of view hIL-11 belongs to the long-helix cytokine superfamily, which is characterized by a conserved core motif consist