Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jose M. Valpuesta"'
Autor:
Marta Ukleja, Jorge Cuellar, Aleksandra Siwaszek, Joanna M. Kasprzak, Mariusz Czarnocki-Cieciura, Janusz M. Bujnicki, Andrzej Dziembowski, Jose M. Valpuesta
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the
Externí odkaz:
https://doaj.org/article/ca87b36036974eccbfea1dd84b813505
Autor:
Kento Morita, Yohei Y. Yamamoto, Ayaka Hori, Tomohiro Obata, Yuko Uno, Kyosuke Shinohara, Keiichi Noguchi, Kentaro Noi, Teru Ogura, Kentaro Ishii, Koichi Kato, Mahito Kikumoto, Rocio Arranz, Jose M. Valpuesta, Masafumi Yohda
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2452 (2018)
Prefoldin is a hexameric molecular chaperone found in the cytosol of archaea and eukaryotes. Its hexameric complex is built from two related classes of subunits, and has the appearance of a jellyfish: Its body consists of a double β-barrel assembly
Externí odkaz:
https://doaj.org/article/4fcc5deffd1d4fe8b4eb660c41631463
Autor:
Amelia Rojas‐Gómez, Sara G. Dosil, Francisco J. Chichón, Nieves Fernández‐Gallego, Alessia Ferrarini, Enrique Calvo, Diego Calzada‐Fraile, Silvia Requena, Joaquin Otón, Alvaro Serrano, Rocio Tarifa, Montserrat Arroyo, Andrea Sorrentino, Eva Pereiro, Jesus Vázquez, José M. Valpuesta, Francisco Sánchez‐Madrid, Noa B. Martín‐Cófreces
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Cell proteostasis includes gene transcription, protein translation, folding of de novo proteins, post‐translational modifications, secretion, degradation and recycling. By profiling the proteome of extracellular vesicles (EVs) from T cells
Externí odkaz:
https://doaj.org/article/92e772c6f8d44bdbb9870fce780f13ea
Autor:
María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline. Here, the authors present the cryo-EM structures of full-length human TH in t
Externí odkaz:
https://doaj.org/article/3b54c91d09444b37ba25ca02cc815dcd
Autor:
Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered
Externí odkaz:
https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe
Autor:
Jorge Cuéllar, W. Grant Ludlam, Nicole C. Tensmeyer, Takuma Aoba, Madhura Dhavale, César Santiago, M. Teresa Bueno-Carrasco, Michael J. Mann, Rebecca L. Plimpton, Aman Makaju, Sarah Franklin, Barry M. Willardson, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
β-propeller domains are an important class of folding substrates for the eukaryotic cytosolic chaperonin CTT. Here the authors find that CTT contributes to the folding and assembly of two β-propeller proteins from mTOR complexes, mLST8 and Raptor,
Externí odkaz:
https://doaj.org/article/23eeb432bf314670b0ab58f513d2d7e9
Autor:
Aitor Franco, Jorge Cuéllar, José Ángel Fernández-Higuero, Igor de la Arada, Natalia Orozco, José M. Valpuesta, Adelina Prado, Arturo Muga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12983 (2021)
The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ability of the cellular protei
Externí odkaz:
https://doaj.org/article/4aee3d07d70c4626ba48ad2d0283857c
Publikováno v:
Nanomaterials, Vol 11, Iss 6, p 1457 (2021)
Herein, we describe the synthesis of highly emissive amphiphilic N-annulated PBI 1 decorated with oligo ethylene glycol (OEG) side chains. These polar side chains allow the straightforward solubility of 1 in solvents of different polarity such as wat
Externí odkaz:
https://doaj.org/article/9c29a2aed8d24621a76538fafac752b0