Výsledky vyhledávání - "Jose M. Trevejo"

Akademický článek

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

Autor: Andrew M. Wollacott, Maciej F. Boni, Kristy J. Szretter, Susan E. Sloan, Mona Yousofshahi, Karthik Viswanathan, Sylvain Bedard, Catherine A. Hay, Patrick F. Smith, Zachary Shriver, Jose M. Trevejo

Publikováno v: EBioMedicine, Vol 5, Iss C, Pp 147-155 (2016)

Background: Seasonal influenza is a major public health concern in vulnerable populations. Here we investigated the safety, tolerability, and pharmacokinetics of a broadly neutralizing monoclonal antibody (VIS410) against Influenza A in a Phase 1 cli

Externí odkaz: https://doaj.org/article/7e7a70614cc6409aaebe54734b502c53

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Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled studyResearch in context

Autor: Patrick F. Smith, Susan Sloan, Ellie Hershberger, David Oldach, Saskia Smits, Zach Shriver, Catherine A. Hay, Rienk E. Jeeninga, Frank Engler, Jose M. Trevejo, Kristin Narayan

Publikováno v: EBioMedicine, Vol 40, Iss, Pp 574-582 (2019)
EBioMedicine

Background: VIS410, a broadly neutralizing monoclonal antibody that binds the hemagglutinin stem of influenza A viruses, was safe and efficacious in a human H1N1 virus challenge study. This study evaluated the safety and tolerability of VIS410 in non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c02ff83d39308db3aad71e502e5c7
http://www.sciencedirect.com/science/article/pii/S2352396418306285

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Pimodivir Treatment in Adult Volunteers Experimentally Inoculated with Live Influenza Virus: A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study

Autor: Johan Vingerhoets, Ramon Polo, Ying Jiang, Mohammed Asmal, Tara L. Kieffer, Sarah Robertson, Jose M Trevejo, Lorant Leopold

Publikováno v: Antiviral Therapy. 23:335-344

Background Pimodivir (formerly JNJ-63623872) is a novel, non-nucleoside polymerase complex inhibitor with in vitro activity against influenza A virus, including pandemic 2009 H1N1, H7N9, H5N1 strains as well as neuraminidase- and amantadine-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70dd4f90aa23e92d96535fdf5de3c8a
https://doi.org/10.3851/imp3212

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Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study

Autor: David Oldach, Zachary Shriver, Susan Sloan, Sylvain Bedard, Kristin Narayan, Patrick F. Smith, Jose M. Trevejo, David Skurnik, Kristy J. Szretter, Bharathi Sundaresh

Publikováno v: Antiviral Research. 184:104763

Influenza A infections cause significant seasonal morbidity and mortality as well as periodic pandemic infections. Currently, no approved therapies exist for patients hospitalized with influenza. The efficacy of VIS410, a broadly neutralizing human i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3be8207b42a7b705d2772480bf426fb
https://doi.org/10.1016/j.antiviral.2020.104763

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The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

Autor: Richard J. Webby, Jose M. Trevejo, Tatiana Baranovich, Marion Russier, Susan Sloan, Kristy J. Szretter, Peter Vogel, Jeremy C. Jones, Patrick Seiler, Elena A. Govorkova

Publikováno v: Antimicrobial Agents and Chemotherapy

Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad28bc829d50fb2252637fb103421b14
https://doi.org/10.1128/aac.02457-15

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Variable Selection Using Iterative Reformulation of Training Set Models for Discrimination of Samples: Application to Gas Chromatography/Mass Spectrometry of Mouse Urinary Metabolites

Autor: Richard G. Brereton, Kanet Wongravee, Michele L. Schaefer, Nina Heinrich, Jose M. Trevejo, Maria E. Holmboe, Randall R. Reed

Publikováno v: Analytical Chemistry. 81:5204-5217

The paper discusses variable selection as used in large metabolomic studies, exemplified by mouse urinary gas chromatography of 441 mice in three experiments to detect the influence of age, diet, and stress on their chemosignal. Partial least squares

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba148abe5a70f46fc529ee1f78e4327d
https://doi.org/10.1021/ac900251c

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Monte-Carlo methods for determining optimal number of significant variables. Application to mouse urinary profiles

Autor: Maria E. Holmboe, Michele L. Schaefer, Randall R. Reed, Gavin R. Lloyd, Richard G. Brereton, John Hall, Kanet Wongravee, Jose M. Trevejo

Publikováno v: Metabolomics. 5:387-406

Three methods for variable selection are described, namely the t-statistic, Partial Least Squares Discriminant Analysis (PLS-DA) weights and regression coefficients, with the aim of determining which variables are the most significant markers for dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fe5da453b3a19d3128116828e54c3b6
https://doi.org/10.1007/s11306-009-0164-4

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Use of cluster separation indices and the influence of outliers: application of two new separation indices, the modified silhouette index and the overlap coefficient to simulated data and mouse urine metabolomic profiles

Autor: Richard G. Brereton, Jose M. Trevejo, Sarah J. Dixon, Maria E. Holmboe, Nina Heinrich, Randall R. Reed, Michele L. Schaefer

Publikováno v: Journal of Chemometrics. 23:19-31

To quantify separate classes, four indices are compared namely the Davies Bouldin index, the silhouette width and two new approaches described in this paper, the modified silhouette width index based on the proportion of objects with a positive silho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d5a2849104dca75a5fa4b17b6d745d4
https://doi.org/10.1002/cem.1189

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