Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jose M. Otero"'
Autor:
David Reza, Rosalino Balo, Jose M. Otero, Ai M. Fletcher, Rebeca García-Fandino, Victor M. Sanchez-Pedregal, Stephen G. Davies, Ramon J. Estevez, Juan C. Estevez
We describe the synthesis of trihydroxylated cyclohexane β-amino acids from (–)-shikimic acid, in their cis and trans configuration, and the incorporation of the trans isomer into a trans-2-aminocyclohexanecarboxylic acid peptide chain. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325ef2db0e5f65058856a31c77d0ff75
https://doi.org/10.26434/chemrxiv-2022-zdb5j
https://doi.org/10.26434/chemrxiv-2022-zdb5j
Autor:
Karina M Madsen, Gupta D B R K Udatha, Saori Semba, Jose M Otero, Peter Koetter, Jens Nielsen, Yutaka Ebizuka, Tetsuo Kushiro, Gianni Panagiotou
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14763 (2011)
BackgroundMetabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective. A systematic
Externí odkaz:
https://doaj.org/article/d8c2384be40748d69cc732ffb8e789ba
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13606 (2010)
BackgroundIdentifying causative biological networks associated with relevant phenotypes is essential in the field of systems biology. We used ferulic acid (FA) as a model antioxidant to characterize the global expression programs triggered by this sm
Externí odkaz:
https://doaj.org/article/b87bd3b422604ccdb51674eaadecff68
Autor:
Peter Mueller, Thomas G. Hampton, Jose M. Otero, Ivo Amende, Ajit Kale, Victor Chu, Katrina Piskorski
Publikováno v:
Alternatives to Laboratory Animals. 32:195-201
Linking gene defect to disease phenotypes in mice has become an essential step in the development of new drugs. Yet, many in vitro and in vivo assays require anaesthetic and surgery or do not reflect physiologically relevant phenomena. The effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec34be8885713a443b292b6e3c0c9e3
https://doi.org/10.1177/026119290403201s33
https://doi.org/10.1177/026119290403201s33
Autor:
Ángela Rodríguez, María Maneiro, Emilio Lence, José M. Otero, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepción González-Bello
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the electrophilicity of specific positions of the ligand towards covalent lysine modification.
Externí odkaz:
https://doaj.org/article/cd7d202952bc4340a777bcf1a88518ac
Autor:
Jose M. Otero, Matthew F. Sullivan, Victor Chu, James P. Morgan, Thomas G. Hampton, Orlando Lopez, Ivo Amende
Publikováno v:
Musclenerve. 26(4)
The mdx mouse is a model of Duchenne muscular dystrophy (DMD). As many DMD patients die of cardiac failure, we investigated whether mdx mice exhibited clinically relevant cardiac phenotypes. We applied a recently developed method for noninvasively re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663359e853500f571937e2a131e08105
https://pubmed.ncbi.nlm.nih.gov/12362417
https://pubmed.ncbi.nlm.nih.gov/12362417
Publikováno v:
BMC Physiology. 1:6
The rapid increase in the development of mouse models is resulting in a growing demand for non-invasive physiological monitoring of large quantities of mice. Accordingly, we developed a new system for recording electrocardiograms (ECGs) in conscious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e621d374323fa4f9f80e8b6ac79b416f
https://doi.org/10.1186/1472-6793-1-6
https://doi.org/10.1186/1472-6793-1-6
Autor:
Carmela Garcia-Doval, José R. Castón, Daniel Luque, Meritxell Granell, José M. Otero, Antonio L. Llamas-Saiz, Madalena Renouard, Pascale Boulanger, Mark J. van Raaij
Publikováno v:
Viruses, Vol 7, Iss 12, Pp 6424-6440 (2015)
Bacteriophage T5, a Siphovirus belonging to the order Caudovirales, has a flexible, three-fold symmetric tail, to which three L-shaped fibres are attached. These fibres recognize oligo-mannose units on the bacterial cell surface prior to infection an
Externí odkaz:
https://doaj.org/article/feeb526dc0a44e799b17aaa3e54d1352
Publikováno v:
ARKIVOC, Vol 2007, Iss 4, Pp 380-388 (2006)
Externí odkaz:
https://doaj.org/article/67f7ca8a391b46039604db279ecea17c