Výsledky vyhledávání - "Jose M. Minguez"

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

Autor: Carolina Burgos, Federico Gago, Jose M. Minguez, Julio Alvarez-Builla, Juan J. Vaquero, Araceli Núñez, Rafael R. Castillo, Emma Terricabras, Ricardo Meneses, Ana Isabel Fraguas Sánchez, Victor Segarra, Álvaro Cortés-Cabrera, Fabiana Filace

Publikováno v: Org. Biomol. Chem.. 12:4233-4242

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b729ca597f4baebd0191231c5468388d
https://doi.org/10.1039/c4ob00175c

Zobrazit plný text záznamu

Regioselective Palladium-Catalyzed Arylation of 4-Chloropyrazoles

Autor: Javier Mendiola, Jose M. Minguez, Mercedes Carpintero, Carlos Mateos

Publikováno v: Organic Letters. 12:4924-4927

A highly regioselective Pd-catalyzed arylation of N-methylpyrazoles with aryl bromides is described. This transformation was studied extensively via automated reaction screening. A Design of Experiments (DoE) approach for optimizing the critical para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1585f56d08a518270eb7662c08994a
https://doi.org/10.1021/ol1020898

Zobrazit plný text záznamu

Ability to grow on lipids accounts for the fully virulent phenotype in neutropenic mice of Aspergillus fumigatus null mutants in the key glyoxylate cycle enzymes

Autor: Fernando Laborda, Israel Olivas, Jose M. Minguez, M. Cândida Monteiro, Mar Royuela, Beatriz Romero, J. Ramón De Lucas

Publikováno v: Fungal Genetics and Biology. 45:45-60

Incidence and mortality rates of invasive aspergillosis clearly indicate the need of novel antifungals to treat patients suffering from this disease. Fungal proteins playing a crucial role in pathogenesis and with no orthologue in human cells are con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e09ceed9d74a4a684175b20b5e779e
https://doi.org/10.1016/j.fgb.2007.05.002

Zobrazit plný text záznamu

Reaction of 2-Bromomethylazoles and TosMIC: A Domino Process to Azolopyrimidines. Synthesis of Core Tricycle of the Variolins Alkaloids

Autor: Jose M. Minguez, Julio Alvarez-Builla, Javier Mendiola, Juan J. Vaquero

Publikováno v: Organic Letters. 2:3253-3256

A new reaction of N-protected 2-bromomethylazoles and tosylmethyl isocyanide (TosMIC) leading to the preparation of azolopyrimidines is described. This domino sequence was used to synthesize the pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine core of alkal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179a8ba8424521888eacf29d084a88ca
https://doi.org/10.1021/ol0062087

Zobrazit plný text záznamu

Pyrrolodiazines. 2. Structure and Chemistry of Pyrrolo[1,2-a]pyrazine and 1,3-Dipolar Cycloaddition of Its Azomethine Ylides

Autor: María I. Castellote, José L. García-Navío, Obis Castaño, Jose L. Andres, Jose M. Minguez, Julio Alvarez-Builla, Juan J. Vaquero

Publikováno v: The Journal of Organic Chemistry. 61:4655-4665

A new synthesis of the pyrrolo[1,2-a]pyrazine system from pyrrole is described. In light of the ab initio calculations carried out on this heterocyclic system some of its basic chemistry was investigated and included electrophilic substitution, addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb88bc4544bd4070b254ee7121f2b123
https://doi.org/10.1021/jo9600969

Zobrazit plný text záznamu

ChemInform Abstract: Regioselective Palladium-Catalyzed Arylation of 4-Chloropyrazoles

Autor: Carlos Mateos, Javier Mendiola, Mercedes Carpintero, Jose M. Minguez

Publikováno v: ChemInform. 42

A library of 5-arylchloropyrazoles is prepared using a wide range of para-, meta-substituted aryl bromides and a 3-pyridyl bromide [cf.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cecb397bc858aa69a40c3f2dd7e713ee
https://doi.org/10.1002/chin.201109125

Zobrazit plný text záznamu

New 3-(2'-benzimidazolyl)imidazo[1,2-a]pyridinium mesomeric betaines. Synthesis and structure

Autor: Federico Gago, Teresa Gandasegui, Angel R. Ortiz, José L. García-Navío, Juan J. Vaquero, M. Melia Rodrigo, Pilar Gómez-Sal, Jose M. Minguez, Julio Alvarez-Builla, R. Torres

Publikováno v: The Journal of Organic Chemistry. 58:6030-6037

Reaction of N-[(2'-benzimidazolyl)methyl]pyridinium salts 2 with isothiocyanates results in a series of 3-(2'-benzimidazolyl)imidazo[1,2-a]pyridinium 2-thiolate derivatives 3 classified as conjugated mesomeric betaines. S-Methylation followed by depr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6bb01a0724d7340e15329f3a8673003
https://doi.org/10.1021/jo00074a033

Zobrazit plný text záznamu

ChemInform Abstract: New 3-(2′-Benzimidazolyl)imidazo(1,2-a)pyridinium Mesomeric Betaines. Synthesis and Structure

Autor: M. Melia Rodrigo, José L. García-Navío, Juan J. Vaquero, R. Torres, Federico Gago, Julio Alvarez-Builla, Jose M. Minguez, Teresa Gandasegui, Pilar Gómez-Sal, Angel R. Ortiz

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e1cda403da57e7fa0284e1ec072a91
https://doi.org/10.1002/chin.199411161

Zobrazit plný text záznamu

ChemInform Abstract: Improved Synthesis of Pyrrolo(1,2-c)pyrimidine and Derivatives

Autor: Jose M. Minguez, José L. García-Navío, Juan J. Vaquero, Julio Alvarez-Builla

Publikováno v: ChemInform. 27

We thank the Comissio Interdepartamental de Reserca i Innovacio Tecnologica (CIRIT) for financial support (project QFN91-4619 ) and the Ministerio de Educacion y Ciencia for a grant (J.M.M.)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c784d2fc564fd4d7026de4cf5ae2a781
https://doi.org/10.1002/chin.199637216

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání