Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jose M. Arencibia"'
Autor:
Sohail Jahid, Jose A. Ortega, Linh M. Vuong, Isabella Maria Acquistapace, Stephanie J. Hachey, Jessica L. Flesher, Maria Antonietta La Serra, Nicoletta Brindani, Giuseppina La Sala, Jacopo Manigrasso, Jose M. Arencibia, Sine Mandrup Bertozzi, Maria Summa, Rosalia Bertorelli, Andrea Armirotti, Rongsheng Jin, Zheng Liu, Chi-Fen Chen, Robert Edwards, Christopher C.W. Hughes, Marco De Vivo, Anand K. Ganesan
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110641- (2022)
Summary: CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here, we use computer
Externí odkaz:
https://doaj.org/article/b20a95d5a6444819bbfaaf7b0c218769
Autor:
Albrecht Piiper, Oliver Waidmann, Thomas J. Vogl, Stefan Zeuzem, Bernd Kronenberger, Horst-Werner Korf, Bernd Groner, Vida Vafaizadeh, Jose M. Arencibia, Ahmed Atef Ibrahim, Eduardo Alonso Augusto, Bianca Kakoschky, Thomas Pleli, Hüdayi Korkusuz, Verena Köberle, Christian Schmithals
Supplementary Figure S3: Body weight of HepG2 (A) and Huh-7 (B) xenograft-bearing mice treated with iRGD, control (Ctl.) peptide, PBS and sorafenib (Sora).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162248249a6792df0df3f94c810a6ab0
https://doi.org/10.1158/0008-5472.22405320
https://doi.org/10.1158/0008-5472.22405320
Autor:
M. De Vivo, Rongsheng Jin, S. J. Hachey, I. M. Acquistapace, Rosalia Bertorelli, Arasu Ganesan, J. L. Flesher, S. Jahid, Jacopo Manigrasso, Nicoletta Brindani, Jose Antonio Ortega, L. M. Vuong, Zhe Liu, M. A. La Serra, Robert A. Edwards, Sine Mandrup Bertozzi, Curtis Chen, Maria Summa, G. La Sala, Christopher C.W. Hughes, Andrea Armirotti, Jose M. Arencibia
Publikováno v:
Cell Rep
Cell reports, vol 39, iss 1
Cell reports, vol 39, iss 1
SUMMARYCDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here we use computer-ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e788e11d6666cbb632d747cd87461b
https://europepmc.org/articles/PMC9128537/
https://europepmc.org/articles/PMC9128537/
Autor:
Nicoletta Brindani, Maria Summa, Stefania Girotto, Rosalia Bertorelli, Marco De Vivo, Sebastian Franco-Ulloa, Jose M. Arencibia, Giuliana Ottonello, Sine Mandrup Bertozzi, Jissy A. Kuriappan, Michela Nigro, Andrea Armirotti
Publikováno v:
Journal of Medicinal Chemistry. 63:3508-3521
We previously reported a first set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers. Here, we report on the expansion of this hybri
Autor:
Jose M, Arencibia, Nicoletta, Brindani, Sebastian, Franco-Ulloa, Michela, Nigro, Jissy Akkarapattiakal, Kuriappan, Giuliana, Ottonello, Sine Mandrup, Bertozzi, Maria, Summa, Stefania, Girotto, Rosalia, Bertorelli, Andrea, Armirotti, Marco, De Vivo
Publikováno v:
Journal of Medicinal Chemistry
We previously reported a first set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers. Here, we report on the expansion of this hybri
Autor:
Marco De Vivo, Jose M. Arencibia, Vito Genna, Maria Summa, Sine Mandrup Bertozzi, Elirosa Minniti, Andrea Armirotti, Sebastian Franco-Ulloa, Jo Ann W. Byl, Claudia Sissi, Rosalia Bertorelli, Neil Osheroff, Marco Borgogno, Anna Minarini, Jose Antonio Ortega
Publikováno v:
J Med Chem
We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do not act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bc28cb9ef7c7a4bbe71fd55bf4856c
http://hdl.handle.net/11577/3367154
http://hdl.handle.net/11577/3367154
Autor:
Vincenza Andrisano, Carmela Fimognari, Vincenzo Tumiatti, Marco B. L. Rocchi, Alan Santini, Dmitri V. Krysko, Ivano Vassura, Marco De Vivo, Serena Montanari, Jose M. Arencibia, Nibal Betari, Elena Catanzaro, Andrea Milelli, Angela De Simone, Claudia Sissi
Drugs targeting human topoisomerase II (topoII) are used in clinical practice since decades. Nevertheless, there is an urgent need for new and safer topoII inhibitors due to the emergence of secondary malignancies and the appearance of resistance mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723fa58b5543ab377464b818b63105d3
https://www.sciencedirect.com/science/article/pii/S0223523420304761?via=ihub
https://www.sciencedirect.com/science/article/pii/S0223523420304761?via=ihub
Autor:
Marco De Vivo, Jose M. Arencibia, Anna Minarini, Elirosa Minniti, Laura Riccardi, José-Antonio Ortega, Maria Laura Greco, Marco Borgogno, Claudia Sissi
Publikováno v:
Journal of medicinal chemistry 61(3), 1375-1379 (2018). doi:10.1021/acs.jmedchem.7b01388
We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity
Autor:
Laura Riccardi, Stefania Girotto, Marco De Vivo, Jose M. Arencibia, Luca Bono, Andrea Armirotti
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:441-451
Human monoacylglycerol lipase (MAGL) is a membrane-interacting enzyme that generates pro-inflammatory signaling molecules. For this reason, MAGL inhibition is a promising strategy to treat pain, cancer, and neuroinflammatory diseases. MAGL can hydrol
Autor:
Christopher C.W. Hughes, Nicoletta Brindani, Stephanie J. Hachey, Chi-Fen Chen, Giuseppina La Sala, Jessica L. Flesher, Anand K. Ganesan, Sohail Jahid, Jose Antonio Ortega, Jacopo Manigrasso, Marco De Vivo, Jose M. Arencibia
Publikováno v:
Cancer Research. 80:5324-5324
The CDC42 family of GTPases (RHOJ, RHOQ, CDC42) control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. While recent studies have developed small molecules that target RAS GTPa