Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment

Autor: Pablo Aliaga-Gaspar, Isaac Hurtado-Guerrero, Nicolas Lundahl Ciano-Petersen, Patricia Urbaneja, Isabel Brichette-Mieg, Virginia Reyes, Jose Luis Rodriguez-Bada, Roberto Alvarez-Lafuente, Rafael Arroyo, Ester Quintana, Lluis Ramió-Torrentà, Ana Alonso, Laura Leyva, Oscar Fernández, Begoña Oliver-Martos

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

PurposeInterferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic cleavage, which has both agonist and antagonist activities for IFN-β

Externí odkaz: https://doaj.org/article/5912837c529b4315bf6dcc4468e175fb

Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation

Autor: Shohreh Issazadeh-Navikas, Isaac Hurtado-Guerrero, José Pavia, María Jesús Pinto-Medel, Patricia Urbaneja, Natalia Mena-Vázquez, A. Alonso, Begoña Oliver-Martos, José Alcamí, Esther Calonge, Oscar Fernández, Laura Leyva, Antonio Alcami, Pablo Aliaga, Jose Luis Rodriguez-Bada, Bruno Hernáez

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 4
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Clinical Medicine, Vol 9, Iss 959, p 959 (2020)
Hurtado-guerrero, I, Hernáez, B, Pinto-medel, M J, Calonge, E, Rodriguez-bada, J L, Urbaneja, P, Alonso, A, Mena-vázquez, N, Aliaga, P, Issazadeh-navikas, S, Pavia, J, Leyva, L, Alcamí, J, Alcamí, A, Fernández, Ó & Oliver-martos, B 2020, ' Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation ', Journal of Clinical Medicine, vol. 9, no. 4, pp. 959 . https://doi.org/10.3390/jcm9040959
Repisalud
Instituto de Salud Carlos III (ISCIII)

Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß
) receptor is ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0674109f235fe62e9bedb2c4821b8dcb
https://hdl.handle.net/20.500.12105/9486

Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway

Autor: Patricia Urbaneja, Begoña Oliver-Martos, Oscar Fernández, María Jesús Pinto-Medel, Pedro Serrano, Laura Leyva, Jose Luis Rodriguez-Bada, Isaac Hurtado-Guerrero, Jesús Ortega-Pinazo

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, their ability to cross-rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad690f5caefd277ed132e8494ed4f4
https://pubmed.ncbi.nlm.nih.gov/29185487

Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis

Autor: María Jesús Pinto-Medel, Jose Luis Rodriguez-Bada, José Pavia, Isaac Hurtado-Guerrero, Begoña Oliver-Martos, Oscar Fernández, Elisa Martín Montañez, Teresa Órpez-Zafra, Laura Leyva

Publikováno v: Bioanalysis. 7(22)

Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, expressed and purified after which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ac7462a91fd7eebb8637bb05a8ac38
https://pubmed.ncbi.nlm.nih.gov/26571364