Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jose Luis Ambite"'
Autor:
Tamoghna Chattopadhyay, Saket S. Ozarkar, Ketaki Buwa, Neha Ann Joshy, Dheeraj Komandur, Jayati Naik, Sophia I. Thomopoulos, Greg Ver Steeg, Jose Luis Ambite, Paul M. Thompson
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Abnormal β-amyloid (Aβ) accumulation in the brain is an early indicator of Alzheimer’s disease (AD) and is typically assessed through invasive procedures such as PET (positron emission tomography) or CSF (cerebrospinal fluid) assays. As new anti-
Externí odkaz:
https://doaj.org/article/441cc4d562d8409e9958a34ee9a28d90
Autor:
Satya S. Sahoo, Matthew D. Turner, Lei Wang, Jose Luis Ambite, Abhishek Appaji, Arcot Rajasekar, Howard M. Lander, Yue Wang, Jessica A. Turner
Publikováno v:
Frontiers in Neuroinformatics, Vol 17 (2023)
BackgroundDespite the efforts of the neuroscience community, there are many published neuroimaging studies with data that are still not findable or accessible. Users face significant challenges in reusing neuroimaging data due to the lack of provenan
Externí odkaz:
https://doaj.org/article/63f062c1b2dc44b1b34660971eab18b3
Autor:
Kenan Li, Katherine Sward, Huiyu Deng, John Morrison, Rima Habre, Meredith Franklin, Yao-Yi Chiang, Jose Luis Ambite, John P. Wilson, Sandrah P. Eckel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Advances in measurement technology are producing increasingly time-resolved environmental exposure data. We aim to gain new insights into exposures and their potential health impacts by moving beyond simple summary statistics (e.g., means, m
Externí odkaz:
https://doaj.org/article/384a2716062c4903b9f6a54dd833d875
Autor:
Yao Hu, Mariaelisa Graff, Jeffrey Haessler, Steven Buyske, Stephanie A Bien, Ran Tao, Heather M Highland, Katherine K Nishimura, Niha Zubair, Yingchang Lu, Marie Verbanck, Austin T Hilliard, Derek Klarin, Scott M Damrauer, Yuk-Lam Ho, VA Million Veteran Program, Peter W F Wilson, Kyong-Mi Chang, Philip S Tsao, Kelly Cho, Christopher J O'Donnell, Themistocles L Assimes, Lauren E Petty, Jennifer E Below, Ozan Dikilitas, Daniel J Schaid, Matthew L Kosel, Iftikhar J Kullo, Laura J Rasmussen-Torvik, Gail P Jarvik, Qiping Feng, Wei-Qi Wei, Eric B Larson, Frank D Mentch, Berta Almoguera, Patrick M Sleiman, Laura M Raffield, Adolfo Correa, Lisa W Martin, Martha Daviglus, Tara C Matise, Jose Luis Ambite, Christopher S Carlson, Ron Do, Ruth J F Loos, Lynne R Wilkens, Loic Le Marchand, Chris Haiman, Daniel O Stram, Lucia A Hindorff, Kari E North, Charles Kooperberg, Iona Cheng, Ulrike Peters
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008684 (2020)
Lipid levels are important markers for the development of cardio-metabolic diseases. Although hundreds of associated loci have been identified through genetic association studies, the contribution of genetic factors to variation in lipids is not full
Externí odkaz:
https://doaj.org/article/ca40beb39a0e40c49b79df873ea4e1d6
Autor:
Bridget M. Lin, Girish N. Nadkarni, Ran Tao, Mariaelisa Graff, Myriam Fornage, Steven Buyske, Tara C. Matise, Heather M. Highland, Lynne R. Wilkens, Christopher S. Carlson, S. Lani Park, V. Wendy Setiawan, Jose Luis Ambite, Gerardo Heiss, Eric Boerwinkle, Dan-Yu Lin, Andrew P. Morris, Ruth J. F. Loos, Charles Kooperberg, Kari E. North, Christina L. Wassel, Nora Franceschini
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
BackgroundChronic kidney disease (CKD) is common and disproportionally burdens United States ethnic minorities. Its genetic determinants may differ by disease severity and clinical stages. To uncover genetic factors associated CKD severity among high
Externí odkaz:
https://doaj.org/article/7ba2ad342bb444b5b8f804c4305a9533
Autor:
Lindsay Fernández-Rhodes, Jennifer R Malinowski, Yujie Wang, Ran Tao, Nathan Pankratz, Janina M Jeff, Sachiko Yoneyama, Cara L Carty, V Wendy Setiawan, Loic Le Marchand, Christopher Haiman, Steven Corbett, Ellen Demerath, Gerardo Heiss, Myron Gross, Petra Buzkova, Dana C Crawford, Steven C Hunt, D C Rao, Karen Schwander, Aravinda Chakravarti, Omri Gottesman, Noura S Abul-Husn, Erwin P Bottinger, Ruth J F Loos, Leslie J Raffel, Jie Yao, Xiuqing Guo, Suzette J Bielinski, Jerome I Rotter, Dhananjay Vaidya, Yii-Der Ida Chen, Sheila F Castañeda, Martha Daviglus, Robert Kaplan, Gregory A Talavera, Kelli K Ryckman, Ulrike Peters, Jose Luis Ambite, Steven Buyske, Lucia Hindorff, Charles Kooperberg, Tara Matise, Nora Franceschini, Kari E North
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200486 (2018)
Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natural menopau
Externí odkaz:
https://doaj.org/article/478f079301344730989cf2747031d6db
Autor:
Sarah A Pendergrass, Kristin Brown-Gentry, Scott Dudek, Alex Frase, Eric S Torstenson, Robert Goodloe, Jose Luis Ambite, Christy L Avery, Steve Buyske, Petra Bůžková, Ewa Deelman, Megan D Fesinmeyer, Christopher A Haiman, Gerardo Heiss, Lucia A Hindorff, Chu-Nan Hsu, Rebecca D Jackson, Charles Kooperberg, Loic Le Marchand, Yi Lin, Tara C Matise, Kristine R Monroe, Larry Moreland, Sungshim L Park, Alex Reiner, Robert Wallace, Lynn R Wilkens, Dana C Crawford, Marylyn D Ritchie
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003087 (2013)
Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for association with phenotypes available for 70,061 study participants in the Population Architecture using Genomics and Epidemiology (PAGE) network
Externí odkaz:
https://doaj.org/article/c6158d1a2b2546dfaf4fd8c71d1e4d61
Autor:
Steven Buyske, Ying Wu, Cara L Carty, Iona Cheng, Themistocles L Assimes, Logan Dumitrescu, Lucia A Hindorff, Sabrina Mitchell, Jose Luis Ambite, Eric Boerwinkle, Petra Buzkova, Chris S Carlson, Barbara Cochran, David Duggan, Charles B Eaton, Megan D Fesinmeyer, Nora Franceschini, Jeffrey Haessler, Nancy Jenny, Hyun Min Kang, Charles Kooperberg, Yi Lin, Loic Le Marchand, Tara C Matise, Jennifer G Robinson, Carlos Rodriguez, Fredrick R Schumacher, Benjamin F Voight, Alicia Young, Teri A Manolio, Karen L Mohlke, Christopher A Haiman, Ulrike Peters, Dana C Crawford, Kari E North
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35651 (2012)
The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SN
Externí odkaz:
https://doaj.org/article/502c705b03d04443920fc5a0d8ff7989
Autor:
Nikhil J. Dhinagar, Sophia I. Thomopoulos, Priya Rajagopalan, Dimitris Stripelis, Jose Luis Ambite, Greg Ver Steeg, Paul M. Thompson
Publikováno v:
18th International Symposium on Medical Information Processing and Analysis.
Deep neural networks show great promise for classifying brain diseases and making prognostic assessments based on neuroimaging data, but large, labeled training datasets are often required to achieve high predictive accuracy. Here we evaluated a rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b5a4a566c4a2b9c3113033c5981541
https://doi.org/10.1117/12.2670457
https://doi.org/10.1117/12.2670457
Autor:
Heather M. Highland, Genevieve L. Wojcik, Mariaelisa Graff, Katherine K. Nishimura, Chani J. Hodonsky, Antoine R. Baldassari, Alanna C. Cote, Iona Cheng, Christopher R. Gignoux, Ran Tao, Yuqing Li, Eric Boerwinkle, Myriam Fornage, Jeffrey Haessler, Lucia A. Hindorff, Yao Hu, Anne E. Justice, Bridget M. Lin, Danyu Lin, Daniel O. Stram, Christopher A. Haiman, Charles Kooperberg, Loic Le Marchand, Tara C. Matise, Eimear E. Kenny, Christopher S. Carlson, Eli A. Stahl, Christy L. Avery, Kari E. North, Jose Luis Ambite, Steven Buyske, Ruth J. Loos, Ulrike Peters, Kristin L. Young, Stephanie A. Bien, Laura M. Huckins
Publikováno v:
Am J Hum Genet
One mechanism by which genetic factors influence complex traits and diseases is altering gene expression. Direct measurement of gene expression in relevant tissues is rarely tenable; however, genetically regulated gene expression (GReX) can be estima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e4fa45e043511beb9496a75528f83
https://doi.org/10.1016/j.ajhg.2022.02.013
https://doi.org/10.1016/j.ajhg.2022.02.013