Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jose L. Tomsig"'
Autor:
Evan P. Taddeo, Stefan R. Hargett, Sujoy Lahiri, Marin E. Nelson, Jason A. Liao, Chien Li, Jill K. Slack-Davis, Jose L. Tomsig, Kevin R. Lynch, Zhen Yan, Thurl E. Harris, Kyle L. Hoehn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Hepatic glucose production (HGP) is required to maintain normoglycemia during fasting. Glucagon is the primary hormone responsible for increasing HGP; however, there are many additional hormone and metabolic factors that influence glucagon s
Externí odkaz:
https://doaj.org/article/e280b7810e98472f94e89b5b849f2537
Autor:
Kyle L. Hoehn, Jill K. Slack-Davis, Kodi S. Ravichandran, Kelle H. Moley, Douglas C. Marchion, Johnathan M. Lancaster, Kristen A. Atkins, William D. Baker, Marin E. Healy, Jenny D.Y. Chow, Jose L. Tomsig, Susan C. Modesitt, Ivan K.H. Poon, Frances L. Byrne
Supplemental Figures S1-8. Figure S1: Protein expression in human endometrial tissue. Figure S2: GLUT6 expression in human endometrial tissue Figure S3: Correlation between metabolic protein expression and metabolism in endometrial cells. Figure S4:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c139e0ded6899be6b48e214b54dc3a
https://doi.org/10.1158/0008-5472.22402731
https://doi.org/10.1158/0008-5472.22402731
Autor:
Kyle L. Hoehn, Jill K. Slack-Davis, Kodi S. Ravichandran, Kelle H. Moley, Douglas C. Marchion, Johnathan M. Lancaster, Kristen A. Atkins, William D. Baker, Marin E. Healy, Jenny D.Y. Chow, Jose L. Tomsig, Susan C. Modesitt, Ivan K.H. Poon, Frances L. Byrne
Supplemental Methods. Includes more detailed methods for the main manuscript and additional supplemental methods including Cell Culture, Sources of drugs/radioactive tracers,Targets/functions of metabolic drugs and antioxidants, Preparation of protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db771c57c8de0d80e626cc822c8590d4
https://doi.org/10.1158/0008-5472.22402728.v1
https://doi.org/10.1158/0008-5472.22402728.v1
Autor:
Kevin R. Lynch, Jose L. Tomsig, Molly D. Congdon, Steven B. Thorpe, Yugesh Kharel, Emily A. Morris, Webster L. Santos
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:23-31
Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity
Autor:
Kyle L. Hoehn, W. Baker, Jenny D.Y. Chow, Kristen A. Atkins, Johnathan M. Lancaster, Susan C. Modesitt, Jose L. Tomsig, Kelle H. Moley, Douglas C. Marchion, Ivan K. H. Poon, Kodi S. Ravichandran, Frances L. Byrne, Jill K. Slack-Davis, Marin E. Healy
Publikováno v:
Cancer Research. 74:5832-5845
Women with metabolic disorders, including obesity and diabetes, have an increased risk of developing endometrial cancer. However, the metabolism of endometrial tumors themselves has been largely understudied. Comparing human endometrial tumors and ce
Autor:
Kyle L. Hoehn, Brandon M. Kenwood, Valeria R. Mas, Robert T. Lawrence, David S. Breen, Frances L. Byrne, Gregory J. Cooney, Pere Puigserver, David E. James, Stephen H. Caldwell, Jenny D.Y. Chow, Jason A. Liao, Carolin Lackner, Saeko Okutsu, Jose L. Tomsig, John E. Dominy, Marin E. Healy, Nigel Turner, Judit Villén
Publikováno v:
Molecular Metabolism
Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; ther
Autor:
Kevin R. Lynch, Jose L. Tomsig, Zhen Yan, Stefan R. Hargett, Evan P. Taddeo, Kyle L. Hoehn, Marin E. Nelson, Jason A. Liao, Sujoy Lahiri, Chien Li, Jill K. Slack-Davis, Thurl E. Harris
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Hepatic glucose production (HGP) is required to maintain normoglycemia during fasting. Glucagon is the primary hormone responsible for increasing HGP; however, there are many additional hormone and metabolic factors that influence glucagon sensitivit
Autor:
Yugesh Kharel, Ming Gao, Amanda M. Gellett, Mithun Raje, Webster L. Santos, Kevin R. Lynch, Jose L. Tomsig
Publikováno v:
Biochemical Journal. 447:149-157
S1P (sphingosine 1-phosphate) is a pleiotropic lipid mediator involved in numerous cellular and physiological functions. Of note among these are cell survival and migration, as well as lymphocyte trafficking. S1P, which exerts its effects via five GP
Autor:
Timothy L. Macdonald, Olivier Peyruchaud, Marion David, Tao Huang, Perry C. Kennedy, Thomas P. Mathews, Ran Zhu, Kevin R. Lynch, Jose L. Tomsig
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 338:879-889
Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration. On a larger physio
Autor:
Andrew J. Kennedy, James E. East, Timothy L. Macdonald, Kevin R. Lynch, Jose L. Tomsig, Alexandra R. De Leon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7132-7136
Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA’s role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA bi