Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Jose L. Sarasa"'
1
Primary Signet-ring Cell/Histiocytoid Carcinoma of the Eyelid
Autor: Heinz Kutzner, Dmitry V. Kazakov, Lorenzo Cerroni, Miguel Seco, Celia Requena, Arno Rütten, Rosa Manzano, Jose L. Sarasa, Victor G. Prieto, Luis Requena
Publikováno v: American Journal of Surgical Pathology. 35:378-391
Primary cutaneous signet-ring cell carcinomas are rare and aggressive neoplasms. These neoplasms have been mostly described in the eyelids, and more uncommonly, in the axillary skin. Histopathologically, the neoplasm seems to be composed of signet-ri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a9c482a29c7245f11257f803190994
https://doi.org/10.1097/pas.0b013e318209cac7
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3
Hypermethylation of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors
Autor: Alberto Isla, Dolores Arjona, M. Eva Alonso, Pilar Gonzalez-Gomez, Jose M. de Campos, Cinthia Amiñoso, Cacilda Casartelli, Jose L. Sarasa, Jesús Vaquero, Juan A. Rey, Manuel Gutierrez, Isabel Lopez-Marin, Nilson Praia Anselmo, M.Elena Kusak, Luis Lassaletta, M. Josefa Bello
Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 554:23-32
O6-methylguanine-DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. By removing alkyl groups from the O6-position in guanine, MGMT can prevent G:C to A:T transition mutations, a type of variation frequentl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4abfa293a83a152c5136283c7bce66
https://doi.org/10.1016/j.mrfmmm.2004.02.011
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4
DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q
Autor: Pilar Gonzalez-Gomez, Cinthia Amiñoso, Dolores Arjona, Jesus Lomas, Isabel Lopez-Marin, M. Josefa Bello, Jose M. de Campos, Jose L. Sarasa, Jesús Vaquero, Juan A. Rey, Manuel Gutierrez, M.Elena Kusak, M. Eva Alonso, Alberto Isla
Publikováno v: Acta Neuropathologica. 108:413-421
The purpose of this research was to examine the DNA methylation profile of meningiomas. Accordingly, we examined the DNA methylation status of ten tumor-related genes (RB1, p16 INK4a , p73, MGMT, ER, DAPK, TIMP-3, p14 ARF , THBS1, and Caspase-8) in 9
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2827780b8ccdd09231826cbd7756da74
https://doi.org/10.1007/s00401-004-0911-6
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5
Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas
Autor: Juan A. Rey, M. Eva Alonso, Pilar Gonzalez-Gomez, Jose L. Sarasa, Jose M. de Campos, Dolores Arjona, Jesus Lomas, Alberto Isla, M. Josefa Bello
Publikováno v: Cancer Genetics and Cytogenetics. 144:134-142
Promoter hypermethylation represents a primary mechanism in the inactivation of tumor suppressor genes during tumorigenesis. To determine the frequency and timing of hypermethylation during carcinogenesis of nonastrocytic tumors, we analyzed promoter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1d497be4ba148f68ba94bf61b43cba
https://doi.org/10.1016/s0165-4608(02)00928-7
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6
CpG island methylation of tumor-related genes in three primary central nervous system lymphomas in immunocompetent patients
Autor: M. Eva Alonso, Dolores Arjona, Jose M. de Campos, Pilar Gonzalez-Gomez, Cinthia Amiñoso, Jesus Lomas, Juan A. Rey, Manuel Gutierrez, Jose L. Sarasa, M. Josefa Bello
Publikováno v: Cancer Genetics and Cytogenetics. 142:21-24
We have determined the promoter CpG island methylation status of O(6)-methylguanine-DNA methyltransferase (MGMT), glutathione-S-transferase P1 (GSTP1), death-associated protein kinase (DAPK), p14(ARF), thrombospondin-1 (THBS1), tissue inhibitor of me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b570cb1616fbb4328fab52d9e965b781
https://doi.org/10.1016/s0165-4608(02)00799-9
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7
Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas
Autor: M. Josefa Bello, Dolores Arjona, M. Eva Alonso, Juan A. Rey, Pilar Gonzalez-Gomez, M.Elena Kusak, Jose M. de Campos, Jesus Lomas, Jose L. Sarasa
Publikováno v: Human Pathology. 33:375-378
Multiple meningiomas are rare, and only 13 cases have been subjected to molecular genetic analysis to detect mutations of the tumor-suppressor gene neurofibromatosis type 2 (NF2) located on chromosome 22. Most of these cases display NF2 gene mutation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929cc421eac9001734b3c512006aa027
https://doi.org/10.1053/hupa.2002.32229
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8
Cutaneous metastases from Ewing's sarcoma: report of two cases
Autor: Jose L. Sarasa, Celia Requena, M J Izquierdo, Lee J. Martin, María Antonia Pastor, Loreto Carrasco, M C Fariña, Luis Requena
Publikováno v: Clinical and Experimental Dermatology. 27:123-128
Ewing's sarcoma is a malignant osseous neoplasm that affects mostly children and young adult males. Clinically, the neoplasm presents with oedema, swelling, and pain of the involved area. Histopathologically, Ewing's sarcoma consists of solid sheets
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::178e3e8357db2386ff2584927e344262
https://doi.org/10.1046/j.1365-2230.2002.00973.x
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9
Analysis of p73 gene in meningiomas with deletion at 1p
Autor: M. Eva Alonso, Pilar Gonzalez-Gomez, Pedro Ruiz-Barnes, Jesus Lomas, Jose M. de Campos, Dolores Arjona, Jesús Vaquero, Juan A. Rey, Cacilda Casartelli, Jose L. Sarasa, M. Josefa Bello
Publikováno v: Cancer Genetics and Cytogenetics. 129:88-91
The p73 gene has been mapped to 1p36.33, a chromosome region that is frequently deleted in a wide variety of neoplasms including meningiomas. The protein encoded by p73 shows structural and functional similarities to p53 and may thus represent a cand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb240857feae30f95c5996d81eb7f78
https://doi.org/10.1016/s0165-4608(01)00430-7
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10
High-Resolution Analysis of Chromosome Arm 1p Alterations in Meningioma
Autor: M.Elena Kusak, Jose L. Sarasa, Jose M. de Campos, M. Josefa Bello, Jesús Vaquero, Juan A. Rey
Publikováno v: Cancer Genetics and Cytogenetics. 120:30-36
Loss of heterozygosity (LOH) for loci on chromosome arm 1p is a relatively common event in human meningioma, and this anomaly has been proposed to be associated with the development of grade II or grade III forms (atypical and anaplastic meningiomas)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778b57cd85ca01ec7c5e77da8b59de12
https://doi.org/10.1016/s0165-4608(99)00249-6
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