Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jose L. Orgaz"'
Autor:
Irene Rodriguez-Hernandez, Oscar Maiques, Leonie Kohlhammer, Gaia Cantelli, Anna Perdrix-Rosell, Joanne Monger, Bruce Fanshawe, Victoria L. Bridgeman, Sophia N. Karagiannis, Rosa M. Penin, Joaquim Marcolval, Rosa M. Marti, Xavier Matias-Guiu, Gilbert O. Fruhwirth, Jose L. Orgaz, Ilaria Malanchi, Victoria Sanz-Moreno
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Externí odkaz:
https://doaj.org/article/9e4929d31dc4466f83996eb59f8cabaf
Autor:
Adrian Barreno, Jose L. Orgaz
Publikováno v:
Cells, Vol 11, Iss 3, p 518 (2022)
Melanoma is an aggressive skin cancer with a poor prognosis when diagnosed late. MAPK-targeted therapies and immune checkpoint blockers benefit a subset of melanoma patients; however, acquired therapy resistance inevitably arises within a year. In ad
Externí odkaz:
https://doaj.org/article/68973cd07c1b48fa83460ae842300e89
Autor:
Remi Samain, Samantha George, Jaume Barcelo, Leonie Kohlhammer, Jose L. Orgaz, Eva Crosas-Molist, Victoria Sanz-Moreno, Oscar Maiques
Publikováno v:
Physiological Reviews. 102:455-510
Rho GTPases are a family of small G proteins that regulate a wide array of cellular processes related to their key roles controlling the cytoskeleton. Cancer is a multistep disease caused by the accumulation of genetic mutations and epigenetic altera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c2b3f230c77f8ec136592806f948e5
https://doi.org/10.1152/physrev.00045.2020
https://doi.org/10.1152/physrev.00045.2020
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 7, Pp 633-642 (2011)
Metastatic melanoma cells are highly adaptable to their in vivo microenvironment and can switch between protease-dependent mesenchymal and protease-independent amoeboid invasion to facilitate metastasis. Such adaptability can be visualized in vitro,
Externí odkaz:
https://doaj.org/article/abf7f92ebf7e42d78a2ec2b5395c9fe7
Autor:
Eva Crosas-Molist, Lena Boehme, Faraz K. Mardakheh, Bruce Fanshawe, Jose L. Orgaz, Gilbert O. Fruhwirth, Irene Rodriguez-Hernandez, Victoria Sanz-Moreno, Oscar Maiques, Gaia Cantelli, Alessia Volpe
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
British Journal of Cancer
BRITISH JOURNAL OF CANCER
instname
British Journal of Cancer
BRITISH JOURNAL OF CANCER
© The Author(s) 2021.
[Background]: Metastasis is a hallmark of cancer and responsible for most cancer deaths. Migrastatics were defined as drugs interfering with all modes of cancer cell invasion and thus cancers’ ability to metastasise. Fir
[Background]: Metastasis is a hallmark of cancer and responsible for most cancer deaths. Migrastatics were defined as drugs interfering with all modes of cancer cell invasion and thus cancers’ ability to metastasise. Fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245a51b1650d282bfda2f05b9dbaede
http://hdl.handle.net/10261/264785
http://hdl.handle.net/10261/264785
Autor:
Aaron J. Farrugia, Javier M. Rodríguez, Jose L. Orgaz, Fernando Calvo, Victoria Sanz-Moreno, María Lucas
Publikováno v:
J Cell Biol. 2020 Sep 7;219(9):e201912159
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
The Journal of Cell Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
The Journal of Cell Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
© 2020 Farrugia et al.
Fast amoeboid migration is critical for developmental processes and can be hijacked by cancer cells to enhance metastatic dissemination. This migratory behavior is tightly controlled by high levels of actomyosin contracti
Fast amoeboid migration is critical for developmental processes and can be hijacked by cancer cells to enhance metastatic dissemination. This migratory behavior is tightly controlled by high levels of actomyosin contracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b701ce851301c0a726828ced5b20cbcc
https://doi.org/10.1083/jcb.201912159
https://doi.org/10.1083/jcb.201912159
Autor:
Joaquim Marcolval, Irene Rodriguez-Hernandez, Ilaria Malanchi, Gilbert O. Fruhwirth, Bruce Fanshawe, Leonie Kohlhammer, Rosa M. Martí, Oscar Maiques, R.M. Penín, Victoria L. Bridgeman, Joanne Monger, Xavier Matias-Guiu, Gaia Cantelli, Anna Perdrix-Rosell, Victoria Sanz-Moreno, Sophia N. Karagiannis, Jose L. Orgaz
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Repositorio Abierto de la UdL
Universitad de Lleida
Rodriguez-Hernandez, I, Maiques, O, Kohlhammer, L, Cantelli, G, Perdrix-Rosell, A, Monger, J, Fanshawe, B, Bridgeman, V L, Karagiannis, S N, Penin, R M, Marcolval, J, Marti, R M, Matias-Guiu, X, Fruhwirth, G O, Orgaz, J L, Malanchi, I & Sanz-Moreno, V 2020, ' WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion ', Nature Communications, vol. 11, no. 1, 5315, pp. 5315 . https://doi.org/10.1038/s41467-020-18951-2
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Consejo Superior de Investigaciones Científicas (CSIC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Repositorio Abierto de la UdL
Universitad de Lleida
Rodriguez-Hernandez, I, Maiques, O, Kohlhammer, L, Cantelli, G, Perdrix-Rosell, A, Monger, J, Fanshawe, B, Bridgeman, V L, Karagiannis, S N, Penin, R M, Marcolval, J, Marti, R M, Matias-Guiu, X, Fruhwirth, G O, Orgaz, J L, Malanchi, I & Sanz-Moreno, V 2020, ' WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion ', Nature Communications, vol. 11, no. 1, 5315, pp. 5315 . https://doi.org/10.1038/s41467-020-18951-2
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30feb0aa6580ce44cc89db78d547e8ed
http://hdl.handle.net/10486/696040
http://hdl.handle.net/10486/696040
Autor:
Jose L. Orgaz, Victoria Sanz-Moreno
Publikováno v:
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Molecular & Cellular Oncology
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Molecular & Cellular Oncology
Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7939c8c55314b03d8610f4b0770518
http://hdl.handle.net/10641/2302
http://hdl.handle.net/10641/2302
Publikováno v:
Current Opinion in Cell Biology. 48:87-96
Collective cell migration is essential during physiological processes such as development or wound healing and in pathological conditions such as cancer dissemination. Cells migrating within multicellular tissues experiment different forces which pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f52c767364717bb6cd578f5ddd772e
https://doi.org/10.1016/j.ceb.2017.06.006
https://doi.org/10.1016/j.ceb.2017.06.006
Publikováno v:
Molecular Oncology
Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94115a715f4fece9f9a8bc1e5e6006c3
https://doi.org/10.1002/1878-0261.12019
https://doi.org/10.1002/1878-0261.12019