Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jose L. Neira"'
Publikováno v:
Molecules, Vol 27, Iss 24, p 8762 (2022)
The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L polymorphism, which may affect the foldin
Externí odkaz:
https://doaj.org/article/70acc055b13a40a58a70307115ca250f
Autor:
Adrian Velazquez-Campoy, Olga Abian, Carlos Marcuello, Anabel Lostao, Sonia Vega, Jose L. Neira
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 13282-13306 (2013)
The nonstructural protein 3 (NS3) from the hepatitis C virus (HCV) is responsible for processing the non-structural region of the viral precursor polyprotein in infected hepatic cells. NS3 protease activity, located at the N-terminal domain, is a zin
Externí odkaz:
https://doaj.org/article/77d8e44ef25642f6a0e02c78a8235b45
Autor:
Olga Abian, Ilaria Bellezza, Ganeko Bernardo-Seisdedos, Isabel Betancor-Fernandez, Jean-Marc Blouin, Kerensa Broersen, Giulia Calloni, Barbara Cellini, Caspar E. Christensen, Francisco Conejero-Lara, Joana S. Cristóvão, Marte I. Flydal, Nicole Fontana, Douglas M. Fowler, David Gil, Cláudio M. Gomes, Sarah Good, Andreas M. Grabrucker, Fedora Grande, Silvia Grottelli, Aylin C. Hanyaloglu, Rasmus Hartmann-Petersen, Emil Hausvik, Jo Ann Janovick, Michael Maglegaard Jepsen, Kresten Lindorff-Larsen, Aurora Martinez, Thomas J. McCorvie, Oscar Millet, Guilherme G. Moreira, Bertrand Morel, Athi N. Naganathan, Jose L. Neira, Sofie V. Nielsen, Angel L. Pey, Emmanuel Richard, Bruno Rizzuti, Eduardo Salido, Signe M. Schenstrøm, Svein I. Støve, Amelie Stein, David J. Timson, Alfredo Ulloa-Aguirre, Jarl Underhaug, R. Martin Vabulas, Patricija van Oosten-Hawle, Sonia Vega, Adrian Velazquez-Campoy, Wyatt W. Yue, Teresa Zariñán
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2304f2aa80cddbaa757da1a8cdd7bac
https://doi.org/10.1016/b978-0-12-819132-3.00022-1
https://doi.org/10.1016/b978-0-12-819132-3.00022-1
Autor:
Salome Araujo-Abad, Bruno Rizzuti, Miguel Vidal, Olga Abian, María Esther Fárez-Vidal, Adrian Velazquez-Campoy, Camino de Juan Romero, José L. Neira
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 561 (2024)
Plakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-containing proteins, is an important structural component of cell–cell adhesion scaffolds although it can also be ubiquitously found in the cytoplasm and the nucl
Externí odkaz:
https://doaj.org/article/92cc9dbc973b42b3a4fa3aec2d263f82
Publikováno v:
Molecules, Vol 28, Iss 22, p 7578 (2023)
MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key tumor-suppressor protein p53. In this work, we explored the stability and the conformational features of the N-terminal region of MDM2 (N-MDM2), through whi
Externí odkaz:
https://doaj.org/article/6084e5f290b0490fa713bcb7b2a831d6
Autor:
Rodrigo J Carbajo, Jose L Neira
This book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistr
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15333 (2022)
The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) comprising residues Pro320 to Asp328, to allow for nuclear tra
Externí odkaz:
https://doaj.org/article/ca2099eaf3974faa8e5eaa2306946ab1
Autor:
Alessio Bonucci, Martina Palomino-Schätzlein, Paula Malo de Molina, Arantxa Arbe, Roberta Pierattelli, Bruno Rizzuti, Juan L. Iovanna, José L. Neira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The intracellular environment is crowded with macromolecules, including sugars, proteins and nucleic acids. In the cytoplasm, crowding effects are capable of excluding up to 40% of the volume available to any macromolecule when compared to dilute con
Externí odkaz:
https://doaj.org/article/4e34d3b00ad74a308779a911a133b13e
Autor:
José L. Neira, Bruno Rizzuti, Olga Abián, Salomé Araujo-Abad, Adrián Velázquez-Campoy, Camino de Juan Romero
Publikováno v:
Cells, Vol 11, Iss 14, p 2166 (2022)
PADI4 is a peptidyl-arginine deiminase (PADI) involved in the conversion of arginine to citrulline. PADI4 is present in macrophages, monocytes, granulocytes, and several cancer cells. It is the only PADI family member observed within both the nucleus
Externí odkaz:
https://doaj.org/article/e314f029b98f48e7a7d33102d877bcf7
Autor:
Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO path
Externí odkaz:
https://doaj.org/article/dff985e07dd843578a4d7c43143ee70d