Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jose L. Estrada"'
Autor:
Cynthia P. Breeden, Jose L. Estrada, Andrew B. Adams, Alfred J. Tector, Luz M. Reyes, Christopher Burlak, Brendan P. Lovasik, Matthew Tector, David A. Faber, Rodrigo M. Vianna
Publikováno v:
Ann Surg
OBJECTIVE Pig-to-primate renal xenotransplantation is plagued by early antibody-mediated graft loss which precludes clinical application of renal xenotransplantation. We evaluated whether temporary complement inhibition with anti-C5 antibody Tesidolu
Autor:
Gregory R. Martens, James R. Butler, Cesare Galli, Conor M. Cunningham, A. Joseph Tector, Joseph M. Ladowski, Luz M. Reyes, Matthew Tector, Jose L. Estrada, Andrea Perota
Publikováno v:
Transgenic Research. 25:751-759
The future of solid organ transplantation is challenged by an increasing shortage of available allografts. Xenotransplantation of genetically modified porcine organs offers an answer to this problem. Strategies of genetic modification have ‘humaniz
Autor:
Zheng Yu Wang, Jessica B. Montgomery, Jose L. Estrada, A. Joseph Tector, Ross L. Blankenship, Ping Li, Matthew Tector, Shunji Nagai, Susan M. Downey, James R. Butler
Publikováno v:
Transplantation. 100:533-537
BACKGROUND Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-α(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human antibody binding to porcine peripheral blood mononuclear cells. It is important t
Autor:
Matthew Tector, Gregory R. Martens, Leela L. Paris, James R. Butler, Ping Li, Ross L. Blankenship, Richard A. Sidner, Jose L. Estrada, A. Joseph Tector, Joseph M. Ladowski
Publikováno v:
Transplantation. 100:571-576
A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury. Recently, inactivation of the porcine ASGR
Autor:
A. Joseph Tector, Zheng Yu Wang, Matthew Tector, Gregory R. Martens, Jose L. Estrada, James R. Butler, Joseph M. Ladowski, Ping Li
Publikováno v:
Journal of Surgical Research. 200:698-706
Background Thrombocytopenia may represent a significant challenge to the clinical application of solid-organ xenotransplantation. When studied in a pig-to-primate model, consumptive coagulopathy has challenged renal xenografts. New strategies of gene
Autor:
Frances M. Platt, Ping Li, Joseph M. Ladowski, Gregory R. Martens, James R. Butler, Jose L. Estrada, David Priestman, A. Joseph Tector, Nicholas J. Skill, Matthew Tector
Publikováno v:
Xenotransplantation. 23:106-116
Background The Galα(1,3)Gal epitope (α-GAL), created by α-1,3-glycosyltransferase-1 (GGTA1), is a major xenoantigen causing hyperacute rejection in pig-to-primate and pig-to-human xenotransplantation. In response, GGTA1 gene-deleted pigs have been
Autor:
Zheng-Yu Wang, Joseph M. Ladowski, Juan Li, Gregory R. Martens, Luz M. Reyes, Jose L. Estrada, A. Joseph Tector
Publikováno v:
The Journal of Immunology. 204:161.29-161.29
Background Xenotransplantation using genetically-engineered (GE) pig organs offers an unlimited supply of organs for patients with end-stage organ failure. Disrupting the porcine GGTA1/CMAH/β4GalNT2 genes (TKO) markedly reduces binding of human natu
Autor:
Gregory R, Martens, Luz M, Reyes, Ping, Li, James R, Butler, Joseph M, Ladowski, Jose L, Estrada, Richard A, Sidner, Devin E, Eckhoff, Matt, Tector, A Joseph, Tector
Publikováno v:
Transplantation
Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA).Peripheral blood mononuclear cells
Autor:
Ping Li, A. Joseph Tector, Christopher Burlak, Zheng Yu Wang, Jose L. Estrada, Matthew Tector
Publikováno v:
Xenotransplantation. 21:376-384
Background Pig erythrocytes are potentially useful to solve the worldwide shortage of human blood for transfusion. Domestic pig erythrocytes, however, express antigens that are bound by human preformed antibodies. Advances in genetic engineering have
Autor:
A. Joseph Tector, Bess Ivary, Leela L. Paris, Luz M. Reyes, Jose L. Estrada, Richard A. Sidner
Publikováno v:
Journal of Surgical Research. 184:e37-e42
Background The process of selecting transgenic cells has been one of the bottlenecks in the generation of transgenic animals by somatic cell nuclear transfer (SCNT). In particular, selection for the Gal double-knockout (Gal-DKO) genotype has been tim