Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jose L Alejo"'
Autor:
Jose L Alejo, Dylan Girodat, Michael J Hammerling, Jessica A Willi, Michael C Jewett, Aaron E Engelhart, Katarzyna P Adamala
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012319 (2024)
Translocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation. An essential conformational change during this process is the swiveling of the small subun
Externí odkaz:
https://doaj.org/article/50452fd9ffea4d23909913eeb26cc25b
Publikováno v:
Biophysical Journal. 121:1541-1548
Biochemical specificity is critical in enzyme function, evolution, and engineering. Here we employ an established kinetic model to dissect the effects of reactant geometry and diffusion on product formation speed and accuracy in the presence of cogna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b9c16ed7f866da3ea795915842aef0
https://doi.org/10.1016/j.bpj.2022.03.005
https://doi.org/10.1016/j.bpj.2022.03.005
Autor:
Wataru Nishima, Dylan Girodat, Mikael Holm, Emily J Rundlet, Jose L Alejo, Kara Fischer, Scott C Blanchard, Karissa Y Sanbonmatsu
Publikováno v:
Nucleic Acids Res
Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational, compositional, and chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c003ca8e4a001aea2d8bef962d4aff9c
https://europepmc.org/articles/PMC9371933/
https://europepmc.org/articles/PMC9371933/
Autor:
Dylan J. Girodat, Wataru Nishima, Mikael Holm, Emily J. Rundlet, Jigneshkumar D. Prajapati, Jose L. Alejo Amaya, Kara Fischer, Scott C. Blanchard, Karissa Y. Sanbonmatsu
Publikováno v:
Biophysical Journal. 122:360a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a367155055ad6eb8583a1e892c478bdf
https://doi.org/10.1016/j.bpj.2022.11.1990
https://doi.org/10.1016/j.bpj.2022.11.1990
Autor:
Jose L. Alejo, Katarzyna P. Adamala
Publikováno v:
Physics of Life Reviews. 33:28-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c25c787b0a21dfa190ad22657b0924
https://doi.org/10.1016/j.plrev.2019.11.003
https://doi.org/10.1016/j.plrev.2019.11.003
Publikováno v:
Nature structural & molecular biology
Directional translocation of the ribosome through the messenger RNA open reading frame is a critical determinant of translational fidelity. This process entails a complex interplay of large-scale conformational changes within the actively translating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c93c97df3ac8d85e04e76a4dd8a9cd1
https://doi.org/10.1038/nsmb.3177
https://doi.org/10.1038/nsmb.3177
Autor:
Jose L. Alejo, Scott C. Blanchard
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Directional transit of the ribosome along the messenger RNA (mRNA) template is a key determinant of the rate and processivity of protein synthesis. Imaging of the multistep translocation mechanism using single-molecule FRET has led to the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb677f2a22c44b4b8b3be7cef90c6b6b
https://doi.org/10.1073/pnas.1707539114
https://doi.org/10.1073/pnas.1707539114
Autor:
Daniel S. Terry, Roger B. Altman, Chad M. Kurylo, Scott C. Blanchard, Matt M. Parks, Manuel F. Juette, Boris Zinshteyn, Jose L. Alejo Amaya, Theresa Vincent, Michael R. Wasserman
Publikováno v:
Biophysical Journal. 116:12a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b4821ad882b90560c96fde03f67d55
https://doi.org/10.1016/j.bpj.2018.11.106
https://doi.org/10.1016/j.bpj.2018.11.106
Akademický článek
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Autor:
Ryan Ferrao, Scott C. Blanchard, Jose L. Alejo, Roger B. Altman, Benjamin J. Burnett, Navdep Kaur, Joshua Kanji
Aminoacyl-tRNA (aa-tRNA) enters the ribosome in a ternary complex with the G-protein elongation factor Tu (EF-Tu) and GTP.EF-Tu·GTP·aa-tRNA ternary complex formation and decay rates are accelerated in the presence of the nucleotide exchange factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1705eee6e364a8360ff4666ef3aa975f
https://europepmc.org/articles/PMC3650427/
https://europepmc.org/articles/PMC3650427/