Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial

Autor: Richard T Davey, Eduardo Fernández-Cruz, Norman Markowitz, Sarah Pett, Abdel G Babiker, Deborah Wentworth, Surender Khurana, Nicole Engen, Fred Gordin, Mamta K Jain, Virginia Kan, Mark N Polizzotto, Paul Riska, Kiat Ruxrungtham, Zelalem Temesgen, Jens Lundgren, John H Beigel, H Clifford Lane, James D Neaton, Jessica Butts, Eileen Denning, Alain DuChene, Eric Krum, Merrie Harrison, Sue Meger, Ross Peterson, Kien Quan, Megan Shaughnessy, Greg Thompson, David Vock, Julia Metcalf, Robin Dewar, Tauseef Rehman, Ven Natarajan, Rose McConnell, Emily Flowers, Kenny Smith, Marie Hoover, Elizabeth M Coyle, David Munroe, Bitten Aagaard, Mary Pearson, Adam Cursley, Helen Webb, Fleur Hudson, Charlotte Russell, Aminata Sy, Cara Purvis, Brooke Jackson, Yolanda Collaco-Moraes, Dianne Carey, Rosemary Robson, Adriana Sánchez, Elizabeth Finley, Donna Conwell, Marcelo H Losso, Luciana Gambardella, Cecilia Abela, Paco Lopez, Helena Alonso, Giota Touloumi, Vicky Gioukari, Olga Anagnostou, Anchalee Avihingsanon, Kanitta Pussadee, Sasiwimol Ubolyam, Bola Omotosho, Clemencia Solórzano, Tianna Petersen, Kranthi Vysyaraju, Stacey A Rizza, Jennifer A Whitaker, Raquel Nahra, John Baxter, Patricia Coburn, Edward M Gardner, James A Scott, Leslie Faber, Erica Pastor, Linda Makohon, Rodger A MacArthur, L Monique Hillman, Marti J Farrough, Hari M Polenakovik, Linda A Clark, Roberto J Colon, Ken M Kunisaki, Miranda DeConcini, Susan A Johnson, Cameron R Wolfe, Laura Mkumba, June Y Carbonneau, Alison Morris, Meghan E Fitzpatrick, Cathy J Kessinger, Robert A Salata, Karen A Arters, Catherine M Tasi, Ralph J Panos, Laura A Lach, Marshall J Glesby, Kirsis A Ham, Valery G Hughes, Robert T Schooley, Daniel Crouch, Leticia Muttera, Richard M Novak, Susan C Bleasdale, Ariel E Zuckerman, Weerawat Manosuthi, Supeda Thaonyen, Thaniya Chiewcharn, Gompol Suwanpimolkul, Sivaporn Gatechumpol, Sirikunya Bunpasang, Brian J Angus, Monique Anderson, Marcus Morgan, Jane Minton, Maria N Gkamaletsou, Joe Hambleton, David A Price, Martin J Llewelyn, Jonathan Sweetman, Javier Carbone, Jose R Arribas, Rocio Montejano, Jose L Lobo Beristain, Iñaki Z Martinez, Jose Barberan, Paola Hernandez, Dominic E Dwyer, Jen Kok, Alvaro Borges, Christian T Brandt, Lene S Knudsen, Nikolaos Sypsas, Costas Constantinou, Antonios Markogiannakis, Spyros Zakynthinos, Paraskevi Katsaounou, Ioannis Kalomenidis, Analia Mykietiuk, Maria F Alzogaray, Mora Obed, Laura M Macias, Juan Ebensrtejin, Patricia Burgoa, Esteban Nannini, Matias Lahitte, Santiago Perez-Patrigeon, José Arturo Martínez-Orozco, Juan Pablo Ramírez-Hinojosa

Publikováno v: The Lancet. Respiratory Medicine
INSIGHT FLU-IVIG Study Group 2019, ' Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG) : a double-blind, randomised, placebo-controlled trial ', The Lancet Respiratory Medicine, vol. 7, no. 11, pp. 951-963 . https://doi.org/10.1016/S2213-2600(19)30253-X

Summary Background Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might have clinical benefit for patients w

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https://pubmed.ncbi.nlm.nih.gov/31582359