Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Autor: Françoise Helmbacher, Jose Jf Millan-Cayetano, Ievgenia Pastushenko, L. Ríos-Buceta, Benjamin Swedlund, Alicia Perez-Bustillo, Magdalena De Troya, Delphi Van Haver, Sergio Hassid, Francis Impens, Bob Meeusen, Sophie Lemaire, Yura Song, Christine Decaestecker, Gaëlle Lapouge, Ramon Sieira-Gil, Cédric Balsat, David Perez-Morga, Beatriz Agreda-Moreno, Cédric Blanpain, Pedro Redondo, Matthieu Opitz, Youri Sokolow, Isabelle Salmon, Christos Sotiriou, Onofre Sanmatrtin, Frédérique De Cock, Virginie Moers, Samuel Scozzaro, Marjorie Vermeersch, Pedro Jaén, Yacine Bareche, Christine Dubois, Milena Rozzi, Nicky D'Haene, Manuel Théry, Yves-Remi Van Eycke, Jeremy Blondeau, Veerle Janssens, Federico Mauri

Publikováno v: Nature
Nature, 2021, 589 (7842), pp.448-455. ⟨10.1038/s41586-020-03046-1⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Nature, Nature Publishing Group, 2021, 589 (7842), pp.448-455. ⟨10.1038/s41586-020-03046-1⟩
Nature (London)

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using

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http://zaguan.unizar.es/record/102099