Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jose J. Lucas"'
Autor:
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols-Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas-Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez-Pastor
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. HTT mutation causes protein misfolding and aggregation, preferentially affecting
Externí odkaz:
https://doaj.org/article/0c91157893d74f8f80789769cd2bc31e
Autor:
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols‑Meade, Sarah N. Larson, Katherine Gundry, Ying Zhang, Cristina Tomas‑Zapico, Jose J. Lucas, Michael Benneyworth, Gülin Öz, Marija Cvetanovic, Alfonso Araque, Rocio Gomez‑Pastor
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/fa1863ab67404351858fc15ac78a69b4
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 1, Pp 23-32 (2011)
The endoplasmic reticulum-stress response is induced in several neurodegenerative diseases and in cellular models of Huntington's disease. However, here we report that the processing of ATF6α to its active nuclear form, one of the three branches of
Externí odkaz:
https://doaj.org/article/148519ebee8b4d1c9d83b7dbe28437ee
Autor:
Xuexin Li, Ivo Hernandez, Maria Häggblad, Louise Lidemalm, Lars Brautigam, Jose J. Lucas, Jordi Carreras-Puigvert, Daniela Hühn, Oscar Fernandez-Capetillo
SUMMARYPolyQ diseases are autosomal dominant neurodegenerative disorders caused by the expansion of CAG repeats. While of slow progression, these diseases are ultimately fatal and lack effective therapies. Here, we present our results from a High-Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2ccdf3e09145aff9bed89b6d515b86
https://doi.org/10.1101/2023.02.06.527298
https://doi.org/10.1101/2023.02.06.527298
Autor:
Ortiz, Inés García, Jiménez, Miriam Martínez, Kavanagh, Tomas, Marshall, Lee, Heath, Anne, Lozano, José J Lucas, Schoefield, Peter R, Mitchell, Philip B, Cooper, Antony A, Fullerton, Janice, Toma, Claudio
Publikováno v:
In European Neuropsychopharmacology October 2023 75 Supplement 1:S245-S245
Akademický článek
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Publikováno v:
Oncotarget
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c9febb919bb404b5133342be62d4c9
https://doi.org/10.18632/oncotarget.18418
https://doi.org/10.18632/oncotarget.18418
In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher i
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 4 (2011)
Increased GSK-3 activity is believed to contribute to the etiology of chronic disorders like Alzheimer’s disease, schizophrenia, diabetes and some types of cancer, thus supporting therapeutic potential of GSK-3 inhibitors. Numerous mouse models wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::927ae5bd958585ace535d55b6912bcc1
http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00045/full
http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00045/full
Autor:
Juan Arranz, Elisa Balducci, Krisztina Arató, Gentzane Sánchez-Elexpuru, Sònia Najas, Alberto Parras, Elena Rebollo, Isabel Pijuan, Ionas Erb, Gaetano Verde, Ignasi Sahun, Maria J. Barallobre, José J. Lucas, Marina P. Sánchez, Susana de la Luna, Maria L. Arbonés
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 210-222 (2019)
Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis and phenotypic manifestatio
Externí odkaz:
https://doaj.org/article/28d366b9092f47de8d16633beced1031