Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jose Imperio"'
Autor:
William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji, Jasvinder K. Atwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglobulin G4 monoclon
Externí odkaz:
https://doaj.org/article/bd282779d343414aa689f312c255a80f
Autor:
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 340-352 (2019)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev
Externí odkaz:
https://doaj.org/article/cd3e464eb6fd4c10b7ea4c66731e7e28
Autor:
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Dongping He, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Externí odkaz:
https://doaj.org/article/58fe892cb1214380bab2aa7374ed2e49
Autor:
Agatha J. Kruse, William J. Meilandt, Guita Lalehzadeh, Hai Ngu, Oded Foreman, Martin Weber, Jose Imperio, Tiffany Wu, Morgan Sheng, David V. Hansen, Kimberly L. Stark, Zora Modrusan, Mandy Kwong, Karpagam Srinivasan, Brad A. Friedman, Alvin Gogineni, Amy Easton, Seung-Hye Lee, Pamela Chan, Justin Elstrott
Publikováno v:
The Journal of Neuroscience
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2ko) at ages ranging from 4 to 22 mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2ded43e8f4be3d4d41f91364b402d
http://europepmc.org/articles/PMC7046459
http://europepmc.org/articles/PMC7046459
Autor:
James A. Ernst, Tim Earr, Guita Lalehzadeh, Travis W. Bainbridge, Susan Crowell, William J. Meilandt, Jose Imperio, Reina N. Fuji, Yanmei Lu, Janice A. Maloney, Jasvinder K. Atwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglobulin G4 monoclonal antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd56a26eaed0bb2a4cfdf03b4b10e492
https://doaj.org/article/bd282779d343414aa689f312c255a80f
https://doaj.org/article/bd282779d343414aa689f312c255a80f
Autor:
Hanna G. Budayeva, Luke Xie, Michael Reichelt, Arundhati Sengupta-Ghosh, Lilian Phu, Timothy K. Earr, Sara L. Dominguez, Amy Easton, Oded Foreman, Gai Ayalon, Kai H. Barck, Donald S. Kirkpatrick, Jose Imperio, Hai Ngu, Jeffrey Eastham-Anderson, Richard A.D. Carano, Yonglei Shang, Zhiyu Jiang, Maj Hedehus, Hao Cai, Isidro Hötzel
Publikováno v:
Neurobiology of Disease, Vol 124, Iss, Pp 340-352 (2019)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181cac452535ef83f80fba179051d0c5
http://www.sciencedirect.com/science/article/pii/S0969996118303978
http://www.sciencedirect.com/science/article/pii/S0969996118303978
Autor:
Amy Easton, Vineela D. Gandham, Martin Weber, Jose Imperio, Jesse E. Hanson, William J. Meilandt, Justin Elstrott
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015c8a1c5d2de7d20312135e32ee904f
https://doi.org/10.1002/alz.045557
https://doi.org/10.1002/alz.045557
Autor:
Joy S. Tea, Oded Foreman, Sara L. Dominguez, Hai Ngu, Amy Easton, Timothy K. Earr, Robert Brendza, Jose Imperio, Baris Bingol, Joshua D. Webster, Domagoj Vucic, Kim Stark, Eugene Varfolomeev
Publikováno v:
Cell Death Differ
RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6202ba1019dfe8ee4603903ffbfaa17
https://pubmed.ncbi.nlm.nih.gov/32994544
https://pubmed.ncbi.nlm.nih.gov/32994544
Autor:
Kai H. Barck, Richard A.D. Carano, Amy Easton, Hai Ngu, Maj Hedehus, Gai Ayalon, Arundhati Sengupta-Ghosh, Dongping He, Hao Cai, Hanna G. Budayeva, Sara L. Dominguez, Michael Reichelt, Lilian Phu, Luke Xie, Donald S. Kirkpatrick, Oded Foreman, Jeffrey Eastham-Anderson, Timothy K. Earr, Isidro Hötzel, Jose Imperio, Yonglei Shang, Zhiyu Jiang
Publikováno v:
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a323e4793a5c95dbbc1ae02a3da96b
http://www.sciencedirect.com/science/article/pii/S0969996119302268
http://www.sciencedirect.com/science/article/pii/S0969996119302268
Autor:
William J. Meilandt, Oded Foreman, Luke Xie, Christopher J. Bohlen, Brad A. Friedman, Amy Easton, Hai Ngu, David V. Hansen, Vineela D. Gandham, Richard A.D. Carano, Guita Lalehzadeh, Mitchell G. Rezzonico, Seung-Hye Lee, Kimberly L. Stark, Jose Imperio, Melanie A. Huntley, Kai H. Barck, Morgan Sheng
Publikováno v:
Neuron. 109:1283-1301.e6
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2 influences lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2c8a3c5d683db273bd161547979e2
https://doi.org/10.1016/j.neuron.2021.02.010
https://doi.org/10.1016/j.neuron.2021.02.010