Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection

Autor: Marta Molinero, Silvia Gómez, Iván D. Benítez, J. J. Vengoechea, Jessica González, Dinora Polanco, Clara Gort-Paniello, Anna Moncusí-Moix, María C. García-Hidalgo, Manel Perez-Pons, Thalía Belmonte, Gerard Torres, Jesús Caballero, Carme Barberà, Jose Ignacio Ayestarán Rota, Lorenzo Socías Crespí, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Antoni Torres, Ferran Barbé, David de Gonzalo-Calvo

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionBronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.AimTo identify the proteomic determinants associated with disease pathogenesis, all-ca

Externí odkaz: https://doaj.org/article/405916dbd8d2452d8e7e2ba57215c1c7

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

Autor: Harald Lapp, Benjamin Dälken, Karl Werdan, J.M. Sirvent, Matthias Kochanek, Matt P. Wise, Antonio Artigas, Gonzalo Sirgo Rodríguez, Stefan Kluge, Jörg Schüttrumpf, Andrea Wartenberg-Demand, Henning Ebelt, Tobias Welte, Juan Bonastre Mora, R. Phillip Dellinger, Sebastian Nuding, Mervyn Singer, Monika Mayer, Jordi Almirall, Miguel Sánchez García, Gabriele Wöbker, Steven M. Opal, Jose Ignacio Ayestarán, Jean Louis Vincent, Antoni Torres, Reimer Riessen, Ricard Ferrer, Miguel Ferrer, Axel Kempa, Iris Bobenhausen, Kai Zacharowski, Ignacio Martin-Loeches, Henrik Reschreiter, Ute Achtzehn, Daniele Wolf, David Brealey, Ulrike Wippermann, Patrick Dubovy, Bernd H. Belohradsky, Jörg Brederlau, Francisco Álvarez-Lerma, Patrick Langohr, Manu Shankar-Hari

Publikováno v: Intensive Care Medicine
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
INTENSIVE CARE MEDICINE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Intensive care medicine, 44 (4

Purpose: The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31858c8dbd5b51341753e91eefcdf2c4
http://europepmc.org/articles/PMC5924663

Impact of a multidisciplinary team for the management of thrombotic microangiopathy.

Autor: Miguel G Uriol Rivera, Sheila Cabello Pelegrin, Carmen Ballester Ruiz, Bernardo López Andrade, Javier Lumbreras, Aina Obrador Mulet, Albert Perez Montaña, Mireia Ferreruela Serlavos, José Ignacio Ayestarán Rota, Joana Ferrer Balaguer, Olga Delgado Sanchez, Lucio Pallares Ferreres, Antonio Mas Bonet, María Jose Picado Valles, Rosa María Ruíz de Gopegui Valero

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206558 (2018)

BACKGROUND:Thrombotic microangiopathy (TMA) is an important complication associated with several diseases that are rare and life-threatening. TMA is common to thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). TTP is defin

Externí odkaz: https://doaj.org/article/4b633820059247b0b2bd696a2da30583