Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jose I. Quetglas"'
Autor:
Sandra Hervas-Stubbs, Cristian Smerdou, Nathalie Thieblemont, Miguel F. Sanmamed, Maria C. Ochoa, Marta Ruiz-Guillen, Jose I. Riezu-Boj, Erkuden Casales, Uxua Mancheño, Juan R. Rodriguez-Madoz, Juan Dubrot, Mercedes Reboredo, Jose I. Quetglas, Ignacio Melero
Supplementary Figures S1-S6. The IFN-I response innduced by SSFV-IL-12 is not affeccted by the IL-12 transgene but is impaired in the absence of IFN-I signaling (S1); IFN-I receptor function is critical for the therapeutic effect of SFV-IL-12 (S2); I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417a92cb113ef3ebaaebcf4aebb9d618
https://doi.org/10.1158/0008-5472.22400862
https://doi.org/10.1158/0008-5472.22400862
Autor:
Sandra Hervas-Stubbs, Cristian Smerdou, Nathalie Thieblemont, Miguel F. Sanmamed, Maria C. Ochoa, Marta Ruiz-Guillen, Jose I. Riezu-Boj, Erkuden Casales, Uxua Mancheño, Juan R. Rodriguez-Madoz, Juan Dubrot, Mercedes Reboredo, Jose I. Quetglas, Ignacio Melero
Host responses are increasingly considered important for the efficacious response to experimental cancer therapies that employ viral vectors, but little is known about the specific nature of host responses required. In this study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09945f2120fc5eb03c7462014beb023c
https://doi.org/10.1158/0008-5472.c.6505704
https://doi.org/10.1158/0008-5472.c.6505704
Autor:
Raul Terron-Exposito, Benoit Dudognon, Inmaculada Galindo, Jose I Quetglas, Julio M Coll, Jose M Escribano, Eduardo Gomez-Casado
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48466 (2012)
Flagellins evoke strong innate and adaptive immune responses. These proteins may play a key role as radioprotectors, exert antitumoral activity in certain types of tumor and reduce graft-versus-host disease in allogeneic hematopoietic stem cell trans
Externí odkaz:
https://doaj.org/article/0878c461a15645ebb0994904db4a6f82
Autor:
Elixabet Bolaños, Alvaro Sanchez-Arraez, Iñaki Etxeberria, Arantza Azpilikueta, Ignacio Melero, Maria E. Rodriguez-Ruiz, Alfonso R. Sánchez-Paulete, Alvaro Teijeira, David Sancho, Jose I. Quetglas, Cristian Smerdou, Pedro Berraondo, Sara Labiano, María Cristina Ballesteros-Briones, Sergio A. Quezada, Noelia Casares
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Instituto de Salud Carlos III (ISCIII)
Multiple lines of evidence indicate a critical role of antigen cross-presentation by conventional BATF3-dependent type 1 classical dendritic cells (cDC1) in CD8-mediated antitumor immunity. Flt3L and XCL1, respectively, constitute a key growth/differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b96de1915b6c6ea07e18757d9572160
https://hdl.handle.net/20.500.12105/9593
https://hdl.handle.net/20.500.12105/9593
Autor:
Ruben Hernandez-Alcoceba, Jesús Prieto, Cristian Smerdou, Joanna Poutou, Jaione Bezunartea, Marta Ruiz-Guillen, Erkuden Casales, Eva Martisova, Marina Ondiviela, María Cristina Ballesteros-Briones, Evgeni Gabev, Alejandro Aranda, Nicola G. A. Abrescia, Jose I. Quetglas
Publikováno v:
Cellular and Molecular Life Sciences
Alphavirus budding is driven by interactions between nucleocapsids assembled in the cytoplasm and envelope proteins present at the plasma membrane. So far, the expression of capsid and envelope proteins in infected cells has been considered an absolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505919353d83338fe575e724168e7403
http://europepmc.org/articles/PMC7079800
http://europepmc.org/articles/PMC7079800
Autor:
Alberto Villanueva, Xavier Matias-Guiu, Iñaki Etxeberria, Jara Palomero, J.M. Piulats, Alvaro Teijeira, Ignacio Melero, Miguel F. Sanmamed, Itziar Otano, Arantza Azpilikueta, Jose I. Quetglas, Elixabet Bolaños, Uxua Mancheño, Maria C. Ochoa, Alena Gros, M. Angela Aznar, Sandra Hervas-Stubbs, Saray Garasa, Inmaculada Rodriguez, Pedro Berraondo, August Vidal, Irene Olivera, Sara Labiano, Susana Inogés, Alfonso R. Sánchez-Paulete
Publikováno v:
Cancer Cell. 36:613-629.e7
Retroviral gene transfer of interleukin-12 (IL-12) into T cells markedly enhances antitumor efficacy upon adoptive transfer but has clinically shown unacceptable severe side effects. To overcome the toxicity, we engineered tumor-specific CD8+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce109b864c048a845532a1889bee28bc
https://doi.org/10.1016/j.ccell.2019.10.006
https://doi.org/10.1016/j.ccell.2019.10.006
Autor:
Uxua Mancheño, Juan R. Rodriguez-Madoz, Mercedes Reboredo, Marta Ruiz-Guillen, Nathalie Thieblemont, Maria C. Ochoa, Juan Dubrot, Ignacio Melero, Erkuden Casales, Sandra Hervas-Stubbs, José-Ignacio Riezu-Boj, Cristian Smerdou, Jose I. Quetglas, Miguel F. Sanmamed
Publikováno v:
Cancer Research. 75:497-507
Host responses are increasingly considered important for the efficacious response to experimental cancer therapies that employ viral vectors, but little is known about the specific nature of host responses required. In this study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2eb76d56aea72051bbfa1eabaa465dd
https://doi.org/10.1158/0008-5472.can-13-3356
https://doi.org/10.1158/0008-5472.can-13-3356
Autor:
Aizea Morales-Kastresana, Sara Labiano, Elixabet Bolaños-Mateo, Esther Wagena, Alvaro Teijeira, Jose I. Quetglas, Peter Friedl, Bettina Weigelin, Alfonso Rodriguez, Arantza Azpilicueta, Lieping Chen, Ivan Martinez-Forero, Ignacio Melero
Publikováno v:
Journal for Immunotherapy of Cancer
Proceedings of the National Academy of Sciences USA, 112, 7551-6
Proceedings of the National Academy of Sciences USA, 112, 24, pp. 7551-6
Proceedings of the National Academy of Sciences USA, 112, 7551-6
Proceedings of the National Academy of Sciences USA, 112, 24, pp. 7551-6
Item does not contain fulltext Cancer immunotherapy is undergoing significant progress due to recent clinical successes by refined adoptive T-cell transfer and immunostimulatory monoclonal Ab (mAbs). B16F10-derived OVA-expressing mouse melanomas resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc59c77c3c9e488245305aa864c50d6e
https://hdl.handle.net/2066/155299
https://hdl.handle.net/2066/155299
Autor:
Maite Alvarez, Itziar Otano, Alvaro Teijeira, Iñaki Etxeberria, Ignacio Melero, Elixabet Bolaños, Sandra Hervas-Stubbs, Susana Inogés, Pedro Berraondo, Jose I. Quetglas, Saray Garasa, Uxua Mancheño, Arantza Azpilicueta, Alfonso R. Sánchez-Paulete
Publikováno v:
Cancer Research. 79:2331-2331
Adoptive T-cell therapy with TILs, CAR-T cells, and TCR-engineered T-cells is achieving remarkable clinical efficacy. Retroviral gene transfer of IL-12 into the T cell cultures markedly enhances efficacy but has shown unacceptable severe side effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f457b4d0d523f300f76a5c5b3f6ee61a
https://doi.org/10.1158/1538-7445.am2019-2331
https://doi.org/10.1158/1538-7445.am2019-2331
Autor:
Sandra Hervas-Stubbs, José Medina-Echeverz, Jaione Bezunartea, Marta Ruiz-Guillen, Juan R. Rodriguez-Madoz, Cristian Smerdou, Erkuden Casales, Pedro Berraondo, Jesús Prieto, Jose I. Quetglas
Publikováno v:
The Journal of Immunology. 190:2994-3004
Semliki Forest virus vectors expressing IL-12 (SFV–IL-12) were shown to induce potent antitumor responses against s.c. MC38 colon adenocarcinomas in immunocompetent mice. However, when MC38 tumors were implanted in liver, where colon tumors usually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4422ea43ba18ac0a907fc1bef76573c4
https://doi.org/10.4049/jimmunol.1201791
https://doi.org/10.4049/jimmunol.1201791