Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Jose Henrique Ledo"'
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Akademický článek
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
Autor: Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz: https://doaj.org/article/d4ab345b9e074e9b86f224c51554c19b
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3
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
Autor: Eitan Wong, Jose Henrique Ledo, Paul Greengard, Ran Zhang, Estefania P. Azevedo, Jerry C. Chang, Victor Bustos, Hernandez Moura Silva, Olga G. Troyanskaya, Thomas Liebmann
Publikováno v: Molecular Psychiatry
Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer’s Disease. An important mechanism of Aβ clearance in the brain is uptake and degradation by microglia. Presenilin 1 (PS1) is the catalytic subunit of γ-secretase, an en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977937f527005c57fe9a3aa8a1755b47
https://doi.org/10.1038/s41380-020-0856-8
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4
Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress
Autor: Lucian Medrihan, Michelle X. Chen, Wei Wang, Jose Henrique Ledo, Junghee Jin, Yong Kim, Kathryn A. McCabe, Dionnet L. Bhatti, Estefania P. Azevedo
BACKGROUND: Behavioral responses to stress are, in part, mediated by the hippocampus and Parvalbumin (PV)-expressing neurons. However, whether chronic stress induces molecular and cellular adaptations in hippocampal PV neurons contribute to stress-in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c2f73293a05ca50e0252aee7b8c84c1
https://doi.org/10.1101/2021.09.14.459024
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Amyloidogenic and anti-amyloidogenic properties of presenilin 1
Autor: Jose Henrique Ledo, Victor Bustos, Maria V. Pulina
Publikováno v: A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165
Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Ab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d95e882c88de17244d2124d23ba8aca
https://doi.org/10.1016/bs.apha.2020.09.010
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Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice
Autor: Danielle Beckman, Licio A. Velloso, Antônio Lúcio Teixeira, Grasielle C. Kincheski, Sergio T. Ferreira, Felipe C. Ribeiro, Helen M. Melo, Fernanda G. De Felice, Luis E. Santos, Maria Bellio, Jose Henrique Ledo, Estefania P. Azevedo, Daniela S. Razolli, Debora Foguel
Publikováno v: The Journal of Neuroscience. 36:12106-12116
Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and depression. However, the molecular mechanisms underlying this connection are largely unknown. We reported recently that soluble Aβ oligomers (AβOs), toxins that a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae858c847b02aa1b5ef2c8dc53482e00
https://doi.org/10.1523/jneurosci.1269-16.2016
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9
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development
Autor: Diego Mourão-Sá, Paul Greengard, Ran Zhang, Luka Mesin, Jose Henrique Ledo, Olga G. Troyanskaya, Estefania P. Azevedo, Victor Bustos
Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56e2b5bc62867632593c4e6968f2303
https://doi.org/10.1371/journal.pone.0237773
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10
Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α
Autor: Dennys E. Cintra, Leticia Forny-Germano, Cláudia P. Figueiredo, Julia R. Clarke, Raphaëlle Pardossi-Piquard, José M. Delgado-García, Frédéric Checler, Marcella Ramos Sant'Ana, Bruno C. de Melo, Helen M. Melo, Vivian S. Miya Coreixas, Sergio T. Ferreira, Licio A. Velloso, Fernanda G. De Felice, Juliana T.S. Fortuna, Camila Vieira Ligo Teixeira, Maira S. Oliveira, Marcio Luiz Figueredo Balthazar, Agnès Gruart, Gisele da S. Seixas da Silva, Jose Henrique Ledo
Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (7), pp.2180-2194.e8. ⟨10.1016/j.celrep.2020.01.072⟩
Cell Reports, Vol 30, Iss 7, Pp 2180-2194.e8 (2020)
Summary: Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, and higher risk of developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e47f55c54a1751a84f01e0ab06816e
https://pubmed.ncbi.nlm.nih.gov/32075735
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