Výsledky vyhledávání - "Jose H. Woodhead"

Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain

Autor: Jose H. Woodhead, Megan Hunt, Laura J. Handy, Karen White, Karen S. Wilcox, Timothy H. Pruess, Misty D. Smith, Fabiola Vanegas, Joel Grussendorf, Reisa K. Krumin, Karolina K. Bulaj, Erin Grussendorf

Publikováno v: Neurochemical Research. 42:1995-2010

The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action in a battery of preclinical pain models in adult male CF#1 mice (formalin, writhing, and tail flick)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d0e489d0b4da2fbf2d02d000bbcc9
https://doi.org/10.1007/s11064-017-2286-9

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Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites

Autor: René H. Levy, Jose H. Woodhead, Boris Yagen, Nina Isoherranen, Meir Bialer, H. Steve White

Publikováno v: Epilepsy Research. 58:1-12

N -methyl-tetramethylcyclopropanecarboxamide (MTMCD) is a new antiepileptic drug (AED) structurally related to valproic acid (VPA) that has a broad spectrum of anticonvulsant activity including models of therapy-resistant epilepsy. The purpose of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea7c3659b44a64e5fe9a84bc42ef74c
https://doi.org/10.1016/j.eplepsyres.2003.12.001

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Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice

Autor: Meir Bialer, H. Steve White, Boris Yagen, Nina Isoherranen, Ofer Spiegelstein, Jose H. Woodhead, Michelle Merriweather, Richard H. Finnell, Bogdan J. Wlodarczyk

Publikováno v: British Journal of Pharmacology. 139:755-764

1 The purpose of this study was to synthesize novel valproyltaurine (VTA) derivatives including valproyltaurinamide (VTD), N-methyl-valproyltaurinamide (M-VTD), N,N-dimethyl-valproyltaurinamide (DM-VTD) and N-isopropyl-valproyltaurinamide (I-VTD) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c10481ac05b5e3a4ae52986f55e9fba
https://doi.org/10.1038/sj.bjp.0705301

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Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents

Autor: Meir Bialer, Ofer Spiegelstein, Jose H. Woodhead, H. Steve White, Richard H. Finnell, Boris Yagen, Gregory D. Bennett, Karen S. Wilcox, Nina Isoherranen, Simcha Blotnik

Publikováno v: British Journal of Pharmacology. 138:602-613

Propylisopropyl acetamide (PID) is a new chiral amide derivative of valproic acid. The purpose of this study was to evaluate the anticonvulsant activity of PID in rodent models of partial, secondarily generalized and sound-induced generalized seizure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::248e3bbccd60948f005c2f6dca409c7c
https://doi.org/10.1038/sj.bjp.0705076

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[Untitled]

Autor: Michael Roeder, Volker Schurig, Brian D. Klein, H. Steve White, Boris Yagen, Meir Bialer, Nina Isoherranen, Jose H. Woodhead

Publikováno v: Pharmaceutical Research. 20:1293-1301

Purpose. Racemic valnoctamide (VCD) is a central nervous system- active drug commercially available in Europe. VCD possesses two chiral centers and, therefore, it exists as a mixture of four stereoisomers. The purpose of this study was to evaluate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85731eaa89bb1747abdcf9e36b3114be
https://doi.org/10.1023/a:1025069519218

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Anticonvulsant Profile and Teratogenicity of N-methyl-tetramethylcyclopropyl Carboxamide: A New Antiepileptic Drug

Autor: Boris Yagen, Nina Isoherranen, Gregory D. Bennett, Meir Bialer, Jose H. Woodhead, H. Steve White, Matthew E. Barton, Karen S. Wilcox, Richard H. Finnell

Publikováno v: Epilepsia. 43:115-126

Summary: Purpose: The studies presented here represent our efforts to investigate the anticonvulsant activity of N-methyl-tetramethylcyclopropyl carboxamide (M-TMCD) and its metabolite tetramethylcyclopropyl carboxamide (TMCD) in various animal (rode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96bdb69f381d087a9879c9837d0abac
https://doi.org/10.1046/j.1528-1157.2002.25801.x

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Anticonvulsant Profile of Valrocemide (TV1901): A New Antiepileptic Drug

Autor: H. Steve White, Jose H. Woodhead, Nina Isoherranen, Meir Bialer

Publikováno v: Epilepsia. 42:831-836

Summary: Purpose: We sought to investigate the anticonvulsant activity of the new antiepileptic drug (AED), valrocemide or TV1901 (VGD) in various animal (rodent) models of human epilepsy to determine its anticonvulsant profile and safety margin. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c572deb855ad6caf54dd84ec53ed8cc6
https://doi.org/10.1046/j.1528-1157.2001.042007831.x

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A Self‐Complementary, Self‐Assembling Microsphere System: Application for Intravenous Delivery of the Antiepileptic and Neuroprotectant Compound Felbamate

Autor: Harold H. Wolf, Gregory S. Shen, R. Tyler McCabe, Huiling Lian, Jose H. Woodhead, Solomon S. Steiner, Christopher A. Rhodes, H. Steve White, R. Duane Sofia

Publikováno v: Journal of Pharmaceutical Sciences. 89:867-875

Felbamate (FBM) is a novel antiepileptic drug (AED) and neuroprotectant (NP) compound that interacts with strychnine‐insensitive (SI) glycine receptors in brain (IC 50 = 374 μM). FBM concentrations required to interact with SI glycine receptors ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f58e9544d246aaa252c6e7c51a23b78b
https://doi.org/10.1002/1520-6017(200007)89:7<867::aid-jps3>3.0.co

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Topiramate Modulates GABA-Evoked Currents in Murine Cortical Neurons by a Nonbenzodiazepine Mechanism

Autor: H. S. White, Jose H. Woodhead, Brown Sd, G. A. Skeen, Harold H. Wolf

Publikováno v: Epilepsia. 41:17-20

Summary: Purpose: These studies further investigate the ability of topiramate (TPM) to enhance γ-aminobutyric acid (GABA)-mediated inhibition through a benzodiazepine-insensitive pathway. Methods: Topiramate (30 and 100 μM) enhancement of GABA (1 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3efa9662892f093ed6900eb6b8a0ee15
https://doi.org/10.1111/j.1528-1157.2000.tb02165.x

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Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold

Autor: H. Steve White, S.Douglas Brown, Jose H. Woodhead, Gwendolyn A Skeen, Harold H. Wolf

Publikováno v: Epilepsy Research. 28:167-179

The anticonvulsant topiramate is effective in laboratory animals against maximal electroshock seizures, amygdala kindling, and spike-wave discharges and has demonstrated efficacy in humans for the treatment of complex partial seizures. However, its m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6079d705b508c5da3f15d0537d06cc
https://doi.org/10.1016/s0920-1211(97)00045-4

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