Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jose Grenet"'
Autor:
Michael DeCupyere, Santhosh A Upadayaya, Gang Wu, Thomas E. Merchant, David W. Ellison, Frederick A. Boop, Suzanne J. Baker, Paige S. Dunphy, Martine F. Roussel, Brent A. Orr, Kimberly S Mercer, Sarah Robinson, Kyle S. Smith, Jose Grenet, Paul Klimo, Giles W. Robinson, Paul A. Northcott, Amar Gajjar, Ke Xu
Publikováno v:
Acta Neuropathologica
Pediatric brain tumors are the leading cause of cancer-related death in children. Patient-derived orthotopic xenografts (PDOX) of childhood brain tumors have recently emerged as a biologically faithful vehicle for testing novel and more effective the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa23e487f4ac5e923a13af6f16d7f96
https://pubmed.ncbi.nlm.nih.gov/32519082
https://pubmed.ncbi.nlm.nih.gov/32519082
Autor:
David B. Finkelstein, Karen Vrijens, Taosheng Chen, Jose Grenet, Jaeki Min, Wilson K. Clements, R. Kiplin Guy, Anang A. Shelat, Wenwei Lin, Martine F. Roussel, Dana Farmer, Jamie R. Genthe
Publikováno v:
ACS Chemical Biology. 12:2436-2447
Here we describe three new small-molecule activators of BMP signaling found by high throughput screening of a library of ~600,000 small molecules. Using a cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed17e46933d04c11e1617f89be76eae
https://doi.org/10.1021/acschembio.7b00527
https://doi.org/10.1021/acschembio.7b00527
Autor:
Anne Corlu, Jill M. Lahti, Vincent J. Kidd, Adeline Busson, Jose Grenet, Pascal Loyer, Mehmet Kocak, Janeen H. Trembley, Wei Zhao
Publikováno v:
Journal of Biological Chemistry. 283:7721-7732
Although it has been reported that cyclin L1α and L2α proteins interact with CDK11p110, the nature of the cyclin L transcripts, the formation of complexes between the five cyclin L and the three CDK11 protein isoforms, and the influence of these co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77fc5aabfa05d0efac05bac36ec8aec7
https://doi.org/10.1074/jbc.m708188200
https://doi.org/10.1074/jbc.m708188200
Autor:
C Fan, Damu Tang, S Cormier, Jose Grenet, J Zhang, K Parihar, Lizhi He, Anthony Bruce, Vincent J. Kidd, Lieqi Liu, Jill M. Lahti
Publikováno v:
Oncogene. 25:5601-5611
Bcl-2 can both promote and attenuate tumorigenesis. Although the former function is relatively well characterized, the mechanism of the latter remains elusive. We report here that enforced Bcl-2 expression in MCF7 cells stabilizes p53, induces phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce9dd9160e72b2fd6893e46b2b94305
https://doi.org/10.1038/sj.onc.1209565
https://doi.org/10.1038/sj.onc.1209565
Autor:
Jill H. Lahti, Dongcheng Wu, Jose Grenet, Vincent J. Kidd, Damu Tang, Lieqi Liu, Alistair J. Ingram, Anil Kapoor, Brie Mazza
Publikováno v:
Journal of Biological Chemistry. 277:12001-12008
Chromatin structure is influenced by histone modification, and this may help direct chromatin behavior to facilitate transcription, DNA replication, and DNA repair. Chromatin condensation and DNA fragmentation are the classic nuclear features but rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a8194e6e3bf93b41faa886540bafb8
https://doi.org/10.1074/jbc.m109219200
https://doi.org/10.1074/jbc.m109219200
Autor:
Gerard P. Zambetti, Amisha Gandhi, Jose Grenet, Linda H. Shapiro, John D. Schuetz, Qingjian Wang, Daxi Sun, Vincent J. Kidd, Janardhan Sampath
Publikováno v:
Journal of Biological Chemistry. 276:39359-39367
The most frequently expressed drug resistance genes, MDR1 and MRP1, occur in human tumors with mutant p53. However, it was unknown if mutant p53 transcriptionally regulated both MDR1 and MRP1. We demonstrated that mutant p53 did not activate either t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba0abe4062378592103ed0d9997c488
https://doi.org/10.1074/jbc.m103429200
https://doi.org/10.1074/jbc.m103429200
Autor:
M B Valentine, Jose Grenet, Jill M. Lahti, E F Vanin, V A Valentine, Tal Teitz, Frederick G. Behm, T Wei, Vincent J. Kidd, A T Look
Publikováno v:
Nature Medicine. 6:529-535
Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we report that the gene for caspase 8 is frequently inactivated in neuroblastoma, a childhood tumor of the peripheral nervou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de284e518a15f7e1c14443d80c3bb24
https://doi.org/10.1038/75007
https://doi.org/10.1038/75007
Publikováno v:
Journal of Biological Chemistry. 274:7245-7252
Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-alpha) or on its own. However, the basis of this CHX-induced apoptosis has not been clearly established. In this study, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86c5d24581f4bdbda112b6c77fea025
https://doi.org/10.1074/jbc.274.11.7245
https://doi.org/10.1074/jbc.274.11.7245
Publikováno v:
Genomics. 52:101-106
The terminal end of the short arm of human chromosome 1, 1p36.3, is frequently deleted in a number of tumors and is believed to be the location of multiple tumor suppressor genes. Thus far, a bona fide tumor suppressor gene from this region has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8abdd691ceab21ca8045aba423dca38
https://doi.org/10.1006/geno.1998.5401
https://doi.org/10.1006/geno.1998.5401
Autor:
Marie-Dominique Galibert, Theodoros I. Roumeliotis, Spiros D. Garbis, Nassima Oumata, Devin Twitchell, Jose Grenet, Jill M. Lahti, Laurent Meijer, Céline Bruyère, Klaus Godl, Eugenia G. Giannopoulou, Nathalie Desban, Nicolas Mouchet, Claire Delehouzé, Hervé Galons, Nadège Loaëc
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2013, pp.1-13. ⟨10.1038/onc.2013.513⟩
Oncogene, 2013, pp.1-13. ⟨10.1038/onc.2013.513⟩
Oncogene, Nature Publishing Group, 2013, pp.1-13. ⟨10.1038/onc.2013.513⟩
Oncogene, 2013, pp.1-13. ⟨10.1038/onc.2013.513⟩
International audience; To understand the mechanisms of action of (R)-roscovitine and (S)-CR8, two related pharmacological inhibitors of cyclin-dependent kinases (CDKs), we applied a variety of '-omics' techniques to the human neuroblastoma SH-SY5Y a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37fc60cfa89fb7cb2f6bc30cbc5dd0
https://hal.archives-ouvertes.fr/hal-01064865
https://hal.archives-ouvertes.fr/hal-01064865
