Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jose Gomez Romo"'
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Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial
Autor: Ezra E.W. Cohen, Lisle Nabell, Deborah J. Wong, Terry Day, Gregory A. Daniels, Mohammed Milhem, Sanjeev Deva, Michael Jameson, Orlando Guntinas-Lichius, Mohammed Almubarak, Matthew Strother, Eric Whitman, Michael Chisamore, Cynthia Obiozor, Teresa Bagulho, Jose Gomez-Romo, Cristiana Guiducci, Robert Janssen, Erick Gamelin, Alain P. Algazi
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 6
Purpose: To determine whether SD-101, a Toll-like receptor 9 agonist, potentiates the antitumor activity of anti-PD-1 antibodies in patients with anti-PD-1/PD-L1 naïve, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Patients and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea5bc50f6ad3d66aef3a82a8a19eef9
https://doi.org/10.1158/1078-0432.ccr-21-1411
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7
Abstract 573: Ex-vivo inhibition of CBL-B with a novel small molecule inhibitor, NX-0255, enhances persistence and anti-tumor activity of adoptively transferred CD8+ T cells in mouse tumor models
Autor: Marilena Gallotta, Jose Gomez Romo, Alexandra Borodovsky, Austin Tenn-McClellan, Jennifer Stokes, Jennifa Gosling, Gwenn M. Hansen, Arthur Sands, Ryan Rountree, Cristiana Guiducci
Publikováno v: Cancer Research. 82:573-573
Adoptive cell transfer (ACT) involving autologous tumor-specific lymphocytes (TIL) has shown promising results in the treatment of advanced cancer. Poor in vitro cell expansion, inefficient T-cell migration and T cell exhaustion in the tumor microenv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96e6600447e8d32913287e34ebc5c28d
https://doi.org/10.1158/1538-7445.am2022-573
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Abstract 1595: Small molecule inhibition of the ubiquitin ligase CBL-B results in potent T and NK cell mediated anti-tumor response
Autor: Arthur T. Sands, Alexandra Borodovsky, Chris Karim, Austin Tenn-McClellan, Jose Gomez Romo, Gwenn M. Hansen, Jennifa Gosling, Jennifer Stokes, Ryan Rountree, Cristiana Guiducci, Marilena Gallotta, Frederick Cohen
Publikováno v: Cancer Research. 81:1595-1595
The E3 ubiquitin ligase Casitas B-lineage lymphoma b (CBL-B) is expressed in T cells where it functions as an important negative regulator of immune activation. CBL-B d attenuates T-cell activation initiated by TCR engagement in part by mediating the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b0ac686db4c8d083b06bab8f0fa8c43
https://doi.org/10.1158/1538-7445.am2021-1595
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Abstract 2259: Tumor abscopal responses induced by the TLR9 agonist, SD-101, are strongly potentiated by a HDAC class I inhibitor, domatinostat
Autor: Cristiana Guiducci, Jose Gomez Romo, Émilie Degagné, Marilena Gallotta, Shravan Kumar Kannan, Robert L. Coffman
Publikováno v: Cancer Research. 79:2259-2259
In cancer settings severe T cell exhaustion is one major road block limiting immunotherapy efficacy. Epigenetic changes happening during T cell effector differentiation lock T cells in a non-programmable state which limits the efficacy of checkpoint
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::559bb14b7577783f35c2d1f13c41d58a
https://doi.org/10.1158/1538-7445.am2019-2259
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