Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jose F. Garcia-Bustos"'
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active agai
Externí odkaz:
https://doaj.org/article/b14af5b8c2d447e7bea5fcfc07284582
Autor:
Yaqing Jiao, Sarah Preston, Jose F. Garcia-Bustos, Jonathan B. Baell, Sabatino Ventura, Thuy Le, Nicole McNamara, Nghi Nguyen, Antony Botteon, Cameron Skinner, Jill Danne, Sarah Ellis, Anson V. Koehler, Tao Wang, Bill C.H. Chang, Andreas Hofmann, Abdul Jabbar, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 59-71 (2019)
In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295, and 14 related tetrahydroquinoxaline analogues against Haemonchus contortus was explored. These compounds were screened against parasitic larvae - exsheath
Externí odkaz:
https://doaj.org/article/caac004597e54aa1a78f4bf273595773
Autor:
Nghi H. Nguyen, Abdul Jabbar, Fei Huang, Sean L. McGee, Yaqing Jiao, Abhijit Kundu, Michael J. Palmer, Banfeng Ruan, Bill C.H. Chang, Thuy G. Le, Jonathan B. Baell, Liam G. Hall, Atanu Ghoshal, Lian Xue, Jose F. Garcia-Bustos, Robin B. Gasser, Timothy N. C. Wells, Sarah Preston, Sheree D. Martin
Publikováno v:
Journal of Medicinal Chemistry. 64:840-844
A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the parasitic nematode of sheep, Haemonchus contortus. These compounds did not show overt cytotoxicity to a range of mammalian cell lines under standard in vitro
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-22 (2019)
Parasites & Vectors
Parasites & Vectors
Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against paras
Autor:
Sasha Hayes, Bill C.H. Chang, Andreas Hofmann, Tao Wang, H. M. P. Dilrukshi Herath, Rohan A. Davis, Jose F. Garcia-Bustos, Abdul Jabbar, R. S. Addison, Sarah Preston, Anson V. Koehler, Robin B. Gasser, Topul Rali
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 72-79 (2019)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs ave
Autor:
Banfeng Ruan, Sarah Preston, Robin B. Gasser, Andreas Hofmann, Thuy G. Le, Timothy N. C. Wells, Lian Xue, Bill C.H. Chang, Jonathan B. Baell, Atanu Ghoshal, Yaqing Jiao, Jennifer Keiser, Abdul Jabbar, Abhijit Kundu, Michael J. Palmer, Fei Huang, Jose F. Garcia-Bustos, Nghi H. Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 62:3367-3380
A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide derivatives. Medicinal chemistr
Autor:
Jose F. Garcia-Bustos, Rebecca J. Gorrell, Alexandra Tikhomirova, Terry Kwok, Despina Kotsanas, Anna Roujeinikova, Joyanta K. Modak, Richard L. Ferrero, Tony M. Korman, Mohammad M. Rahman, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1660-1667 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Ethoxzolamide (EZA), acetazolamide, and methazolamide are clinically used sulphonamide drugs designed to treat non-bacteria-related illnesses (e.g. glaucoma), but they also show antimicrobial activity against the gastric pathogen Helicobacter pylori.
Autor:
Thuy G. Le, Nghi H. Nguyen, Jose F. Garcia-Bustos, Yaqing Jiao, Andreas Hofmann, Banfeng Ruan, Abdul Jabbar, Abhijit Kundu, Robin B. Gasser, Jonathan B. Baell, Sarah Preston, Timothy N. C. Wells, Bill C.H. Chang, Atanu Ghoshal, Fei Huang, Michael J. Palmer, Jennifer Keiser, Lian Xue
Publikováno v:
Journal of Medicinal Chemistry. 62:1036-1053
Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC50 value of 0.03 μM while displaying good sel
Autor:
Lyn-Marie Birkholtz, Keith Al-Hasani, Mitchell B Batty, Belinda Joan Morahan, Jose F. Garcia-Bustos, Victoria C. Corey, Christian Doerig, Elizabeth A. Winzeler, Clarissa Abrie, Anne N. Cowell, Jandeli Niemand
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious opportunity for therapeutic intervention against malaria. Mitosis is controlled through the
Autor:
Christian Doerig, Dominique Dorin-Semblat, Mitchell B Batty, Ralf B. Schittenhelm, Jose F. Garcia-Bustos
Publikováno v:
IUBMB lifeREFERENCES. 72(6)
A pool of Plasmodium falciparum casein kinase 1 (PfCK1) has been shown to localize to the host red blood cell (RBC) membrane and be secreted to the extracellular medium during trophozoite stage of development. We attempted to identify mechanisms for